An organ-on-chip (OOC) is a microfluidic 3D cell culture chip that simulates the physiological microenvironment of human organs. These chips are usually transparent, flexible and about the size of a computer memory stick.
OOCs are one of the most exciting multidisciplinary areas of scientific research. They have the distinguishing characteristic of emulating the human micro environment in vitro, which is not possible by any other conventional in-vitro techniques. This unique feature of an OOC is the result of integrating biology with technology.
Scientific advances in cell biology, microfabrication and microfluidics have led to the development of OOCs. They are tiny chip-like structures with specific embedded cells. The combination of chip and cells in the presence of suitable conditions mimic the key functions of an organ in miniature formats outside the body. Organs that have been simulated by microchips include the heart, lung, kidney, artery, bone, cartilage, skin and more.
"Integration of technology and science led to the development of OOC devices. These micro devices can discard a significant proportion of ineffective drug molecules in the early stages of drug development. They can be employed in every aspect of drug discovery and development, but currently these chips are more commonly being used for preclinical drug toxicity testing and for lead identification."
The design of a human-on-chip is achieved by integrating multiple organ-on-chips. Most organ-on-chips are seeded with specified cell lines which represent the physiological functions of individual organs. Hence to evaluate the effects of the drug simultaneously on multiple organ systems, a human-on-chip is developed. The pharmacological effects of a drug molecule on any of the specific organ systems along with the adverse events or side effects which it might cause on other body parts can be evaluated on the human-on-chip. The human-on-chip devices and models are used to shorten the drug discovery cycle and provide critical information on drug safety and efficacy.
The global OOC market was valued at around USD3.5 million in 2010. It reached around USD31 million in 2015. It is forecasted to reach over USD450 million by 2020.
The key drivers that effect on the growth rate of the OOC market are Government Funding, Improved Drug Screening and Decrease In Drug Testing Costs. While major restraints on the OOC market include Complex Manufacturing Techniques, Requirement For Specialized Equipment, and Regulatory Hurdles For Drug Approvals. OOC development is supported by grants from several government and non-government bodies.
The provision of grants is considered as a key driver for the global OOC market.
OOCs are still at initial stages of development. In spite of being a new technology, however, OOC has gained prominence in the last few years. Currently the technology is not being leveraged very significantly across the pharmaceutical industry for their experimental needs. However, both the big pharmaceutical players and the small biotech firms are now showing a high level of interest in OOC.
Only a few companies are developing OOCs. Each spinoff company maintains and follows its own proprietary methodologies for designing and manufacturing OOCs. The level of competition amongst these few players is moderate. Each is involved in robust R&D activities to innovate new models of OOC. As a result competition is likely to intensify in the coming years. There are also likely to be new spinoff companies from the universities.
Key Players in The OOC market include CN Bio Innovations, Emulate, TissUse, Mimetas, H�REL, Nortis, Insphero, Tara Biosystems, and AxoSim Techologies LLC.
Global Organ-On-Chip Market
Global Organ-On-Chip Market-Introduction
Global Organ-On-Chip Market-Product Analysis
Typical Organ-On-Chip Structure
Product Design Materials
Product Designing Methodologies
Overview Of Organ Specific Models
Global Organ-On-Chip Market-Market Characteristics And Trends
Organ-On-Chip Market Penetration
Five Force Analysis
Organ-On-Chip Market Trends
Developments In The Testing Of Human Organs-On-Chip
Organ-On-Chip Technology In Space
Automated Monitoring Of Organ-On-Chips
3D Printing Of Organ-On-Chips
Manufacturers Tie Up With End-Users To Design Tailor-Made Products
Investment In Integration Of Individual Organ-On-Chips Into Human-On-Chip
Strong Focus On Development Of Custom Organ-On-Chip
Manufacturers Work On Disease Models To Expedite Drug Testing
Increased Use Of Organ-On-Chips For Stratified/ Personalized Medicine
Global Organ-On-Chip Market-Market Size Analysis
Global Market For Organ-On-Chip (Historic 2012-2016) USD
Global Market For Organ-On-Chip (Forecast 2016-2020) USD
Global Organ-On-Chip Market Segmentation By Organ Type
Global Organ-On-Chip Market Segmentation By Geography
Rest of World (ROW)
Global Organ-On-Chip Market Segmentation By End Users
Consumer Goods and Cosmetics
Food and Beverage
Global Organ-On-Chip Market-Market Drivers And Restraints
Government Funding Drives The Market For Organ-On-Chips
Improved Drug Screening With Organ-On-Chips Will Drive Its Demand
Decrease In Drug Testing Costs Using Organ-On-Chips Will Drive Its Demand
Ethical Concerns With Respect To Animal Models Will Drive the Organ-On-Chip Market
Complex Manufacturing Techniques Are A Restraint On Organ-On-Chip Market Growth
Requirement For Specialized Equipment Will Be A Challenge For The Organ-On-Chip Market
Regulatory Hurdles For Drug Approvals ?
Global Organ-On-Chip Market-Funding Landscape
Funding Landscape-North America
Global Organ-On-Chip Market-Competitive Landscape
Key Competitor Analysis
Key Players In The OOC Market
CN Bio Innovations
Axosim Technologies LLC
Global Organ-On-Chip Market-Business Models
Commercial Industries/End Users
Global Organ-On-Chip Conclusions & Strategies
The Business Research Company
Figure 1: Global Organ-On-Chip Market, Typical Structure Of An Organ-On-Chip
Figure 2: Global Organ-On-Chip Market, Lung-On-Chip Model
Figure 3: Global Organ-On-Chip Market, Design Of Human-On-Chip Prototype
Figure 4: Global Organ-On-Chip Market, Five Force Analysis
Figure 5: Global Organ-On-Chip Market, 2012-2016, Value (USD Millions)
Figure 6: Global Organ-On-Chip Market, 2016-2020, Value (USD Millions),
Figure 7: Organ-On-Chip Market, Segmentation By Organ Type, 2016, Value (USD Millions)
Figure 8: North America Organ-On-Chip Market Size, 2012-2016, Value (USD Millions)
Figure 9: North America Organ-On-Chip Market Size, 2016-2020, Value (USD Millions)
Figure 10: Europe Organ-On-Chips Market Size, 2012-2016, Value (USD Millions)
Figure 11: Europe Organ-On-Chip Market Size, 2016-2020, Value (USD Millions)
Figure 12: Asia Organ-On-Chip Market Size, 2012-2016, Value (USD Millions)
Figure 13: Asia Organ-On-Chips Market Size, 2016-2020, Value (USD Million)
Figure 14: ROW Organ-On-Chip Market Size, 2012-2016, Value (USD Millions)
Figure 15: ROW Organ-On-Chips Market Size, 2016-2020, Value (USD Million)
Figure 16: Organ-On-Chip Market, Segmentation By End User Market 2016, Value (USD Millions)
Figure 17: Global Organ-On-Chip Market, Predictability Scale Of Techniques Used In Drug Screening And Evaluation 33
Figure 18: Global Organ-On-Chip Market, Number Of New Drug Approvals By FDA And EMA, 2012-2016
Figure 19: Global Organ-On-Chip Market, Organ-On-Chips Pricing, 2016
Figure 20: Global Organ-On-Chip Market, Typical Business Model Of Organ-On-Chip Companies
Figure 21: Global Organ-On-Chips Market, Segmentation By End Users, 2016 (USD Million)
Table 1: Global Organ-On-Chip Market, Top Pharmaceutical Companies-R&D Expenditures, Value (USD Billions)
Table 2: Global Organ-On-Chips Market, Grants Under Tissue Chip For Drug Screening Initiative
Table 3: Global Organ-On-Chips Market, CN Bio Collaborations With Pharmaceutical Companies
Table 4: Global Organ-On-Chips Market, CN Bio Collaborations With Academic Universities/Institutes
Table 5: Global Organ-On-Chips Market, Mimetas' Collaborations With Industries And Universities
Table 6: Global Organ-On-Chips Market, CN Bio Innovation'sProduct Details
Table 7: Global Organ-On-Chips Market, Emulate'sProduct Details
Table 8: Global Organ-On-Chips Market, Tissuse'sProduct Details
Table 9: Global Organ-On-Chips Market, Mimetas'sProduct Details
Table 10: Global Organ-On-Chips Market, Hmrel'sProduct Details
Table 11: Global Organ-On-Chips Market, Nortis'sProduct Details
Table 12: Global Organ-On-Chips Market, Insphero'sProduct Portfolio
Table 13: Global Organ-On-Chips Market, Axosim Techologies LLC'sProduct Portfolio
Table 14: Global Organ-On-Chips Market, Academic And Industrial Collaboration Partners Of Insphero?
CN Bio Innovations, Emulate Inc., TissUse GmbH, Mimetas, HMREL Corporation (HMREL), Nortis, InSphero, Tara Biosystems, and AxoSim Techologies LLC
Lung-on-chip, Heart-on-chip, Liver-on-chip, Intestine-on-chip, Kidney-on-chip and Human-on-chip
select a license
NEWSLETTER BY CATEGORY
The report was very informative and gives me an interesting view on the Indian market.... "Area Sales Manager, Muhlen Sohn GmbH & Co. KG"
We would like to thank the entire team of Ken Research in showcasing professionalism in research and quick turnaround time. We have had multiple research reports from Ken Research. The deadline communicated for research was duly met. The research reports were covering many aspects in detail. This showcases their endeavor and care for client satisfaction and a strong understanding of the clients’ requirements. Thank you again for your help... "Group Vice President Strategy, Aliaxis"
I appreciate their diligence and determination in customizing the research project. The data proves to be valuable and accurate. I would, in future, definitely use their services again... "Technical Marketing Manager, Ascendis Health Limited"
I would like to thank Ken research team for meeting our report deliverables. The report is very good and we appreciate your well cooperation. ... "., Coldwell Banker - Riyadh "
The research you conducted was very helpful for us and the integrity of your research approach gave us great confidence in the data. Look forward to collaborating again in future... "International and Business Dev. Director, Duta Abadi Primantara"