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Ageing-Pipeline Review, H1 2015

Ageing-Pipeline Review, H1 2015


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Executive Summary

Ageing-Pipeline Review, H1 2015

Summary

Global Markets Direct's, 'Ageing-Pipeline Review, H1 2015', provides an overview of the Ageing's therapeutic pipeline.

This report provides comprehensive information on the therapeutic development for Ageing, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Ageing and special features on late-stage and discontinued projects.

Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis.

The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.

Scope

The report provides a snapshot of the global therapeutic landscape of Ageing

The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities

The report reviews key players involved in the therapeutics development for Ageing and enlists all their major and minor projects

The report summarizes all the dormant and discontinued pipeline projects

A review of the Ageing products under development by companies and universities/research institutes based on information derived from company and industry-specific sources

Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages

A detailed assessment of monotherapy and combination therapy pipeline projects

Coverage of the Ageing pipeline on the basis of target, MoA, route of administration and molecule type

Latest news and deals relating related to pipeline products

Reasons To Buy

Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies

Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage

Develop strategic initiatives by understanding the focus areas of leading companies

Identify and understand important and diverse types of therapeutics under development for Ageing

Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline

Devise corrective measures for pipeline projects by understanding Ageing pipeline depth and focus of Indication therapeutics

Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline

Table of Contents

Table of Contents 2

List of Tables 4

List of Figures 5

Introduction 6

Global Markets Direct Report Coverage 6

Ageing Overview 7

Therapeutics Development 8

Pipeline Products for Ageing-Overview 8

Pipeline Products for Ageing-Comparative Analysis 9

Ageing-Therapeutics under Development by Companies 10

Ageing-Therapeutics under Investigation by Universities/Institutes 11

Ageing-Pipeline Products Glance 12

Clinical Stage Products 12

Early Stage Products 13

Ageing-Products under Development by Companies 14

Ageing-Products under Investigation by Universities/Institutes 15

Ageing-Companies Involved in Therapeutics Development 16

Bioo Therapeutics 16

Neuralstem, Inc. 17

RepliCel Life Sciences, Inc. 18

RXi Pharmaceuticals Corporation 19

Ageing-Therapeutics Assessment 20

Assessment by Monotherapy Products 20

Assessment by Combination Products 21

Assessment by Target 22

Assessment by Mechanism of Action 24

Assessment by Route of Administration 26

Assessment by Molecule Type 28

Drug Profiles 30

BIOO-4-Drug Profile 30

Product Description 30

Mechanism of Action 30

R&D Progress 30

BIOO-7-Drug Profile 31

Product Description 31

Mechanism of Action 31

R&D Progress 31

Drugs for Ageing-Drug Profile 32

Product Description 32

Mechanism of Action 32

R&D Progress 32

metformin + sirolimus-Drug Profile 33

Product Description 33

Mechanism of Action 33

R&D Progress 33

MG-29-Drug Profile 34

Product Description 34

Mechanism of Action 34

R&D Progress 34

MMP-26051-Drug Profile 35

Product Description 35

Mechanism of Action 35

R&D Progress 35

MMP-26052-Drug Profile 36

Product Description 36

Mechanism of Action 36

R&D Progress 36

NSI-189-Drug Profile 37

Product Description 37

Mechanism of Action 37

R&D Progress 37

RCS-01-Drug Profile 38

Product Description 38

Mechanism of Action 38

R&D Progress 38

sirolimus-Drug Profile 39

Product Description 39

Mechanism of Action 39

R&D Progress 39

Small Molecule for Alzheimer's Disease and Ageing-Drug Profile 40

Product Description 40

Mechanism of Action 40

R&D Progress 40

Small Molecules to Activate Telomerase for ALS, GVHD, Ageing and Leukemia-Drug Profile 41

Product Description 41

Mechanism of Action 41

R&D Progress 41

TM-5441-Drug Profile 42

Product Description 42

Mechanism of Action 42

R&D Progress 42

Ageing-Recent Pipeline Updates 43

Ageing-Dormant Projects 46

Ageing-Product Development Milestones 47

Featured News & Press Releases 47

Oct 09, 2014: RepliCel to Present Commercial and Clinical Update on RCS-01 at BioJapan 2014 World Business Forum 47

Appendix 48

Methodology 48

Coverage 48

Secondary Research 48

Primary Research 48

Expert Panel Validation 48

Contact Us 48

Disclaimer 49

List of Tables

Number of Products under Development for Ageing, H1 2015 8

Number of Products under Development for Ageing-Comparative Analysis, H1 2015 9

Number of Products under Development by Companies, H1 2015 10

Number of Products under Investigation by Universities/Institutes, H1 2015 11

Comparative Analysis by Clinical Stage Development, H1 2015 12

Comparative Analysis by Early Stage Development, H1 2015 13

Products under Development by Companies, H1 2015 14

Products under Investigation by Universities/Institutes, H1 2015 15

Ageing-Pipeline by Bioo Therapeutics, H1 2015 16

Ageing-Pipeline by Neuralstem, Inc., H1 2015 17

Ageing-Pipeline by RepliCel Life Sciences, Inc., H1 2015 18

Ageing-Pipeline by RXi Pharmaceuticals Corporation, H1 2015 19

Assessment by Monotherapy Products, H1 2015 20

Assessment by Combination Products, H1 2015 21

Number of Products by Stage and Target, H1 2015 23

Number of Products by Stage and Mechanism of Action, H1 2015 25

Number of Products by Stage and Route of Administration, H1 2015 27

Number of Products by Stage and Molecule Type, H1 2015 29

Ageing Therapeutics-Recent Pipeline Updates, H1 2015 43

Ageing-Dormant Projects, H1 2015 46

List of Figures

Number of Products under Development for Ageing, H1 2015 8

Number of Products under Development for Ageing-Comparative Analysis, H1 2015 9

Number of Products under Development by Companies, H1 2015 10

Number of Products under Investigation by Universities/Institutes, H1 2015 11

Comparative Analysis by Early Stage Products, H1 2015 13

Assessment by Monotherapy Products, H1 2015 20

Number of Products by Top 10 Targets, H1 2015 22

Number of Products by Stage and Top 10 Targets, H1 2015 23

Number of Products by Top 10 Mechanism of Actions, H1 2015 24

Number of Products by Stage and Top 10 Mechanism of Actions, H1 2015 25

Number of Products by Top 10 Routes of Administration, H1 2015 26

Number of Products by Stage and Top 10 Routes of Administration, H1 2015 27

Number of Products by Top 10 Molecule Types, H1 2015 28

Number of Products by Stage and Top 10 Molecule Types, H1 2015 29

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Bioo Therapeutics

Neuralstem, Inc.

RepliCel Life Sciences, Inc.

RXi Pharmaceuticals Corporation

Ageing Therapeutic Products under Development, Key Players in Ageing Therapeutics, Ageing Pipeline Overview, Ageing Pipeline, Ageing Pipeline Assessment


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