Bone Marrow Transplant Rejection-Pipeline Review, H1 2017

Bone Marrow Transplant Rejection-Pipeline Review, H1 2017


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Executive Summary

Bone Marrow Transplant Rejection-Pipeline Review, H1 2017

Summary

Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Bone Marrow Transplant Rejection-Pipeline Review, H1 2017, provides an overview of the Bone Marrow Transplant Rejection (Immunology) pipeline landscape.

Bone marrow transplant rejection is a complication that can occur after a stem cell or bone marrow transplant. The newly transplanted donor cells attack the transplant recipient's body. Symptoms include chest pain, chills, drop in blood pressure, fever, flushing, funny taste in the mouth, headache, hives, nausea, pain and shortness of breath. Treatment includes immunosuppressive drugs.

Report Highlights

Global Markets Direct's Pharmaceutical and Healthcare latest pipeline guide Bone Marrow Transplant Rejection-Pipeline Review, H1 2017, provides comprehensive information on the therapeutics under development for Bone Marrow Transplant Rejection (Immunology), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases.

The Bone Marrow Transplant Rejection (Immunology) pipeline guide also reviews of key players involved in therapeutic development for Bone Marrow Transplant Rejection and features dormant and discontinued projects. The guide covers therapeutics under Development by Companies /Universities /Institutes, the molecules developed by Companies in Filing rejected/Withdrawn, Phase III, Phase II, Phase I, IND/CTA Filed, Preclinical, Discovery and Unknown stages are 1, 9, 26, 16, 1, 35, 6 and 3 respectively. Similarly, the Universities portfolio in Phase II, Phase I, Preclinical and Discovery stages comprises 2, 3, 13 and 3 molecules, respectively.

Bone Marrow Transplant Rejection (Immunology) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. The guide is built using data and information sourced from Global Markets Direct's proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis.

Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope

The pipeline guide provides a snapshot of the global therapeutic landscape of Bone Marrow Transplant Rejection (Immunology).

The pipeline guide reviews pipeline therapeutics for Bone Marrow Transplant Rejection (Immunology) by companies and universities/research institutes based on information derived from company and industry-specific sources.

The pipeline guide covers pipeline products based on several stages of development ranging from pre-registration till discovery and undisclosed stages.

The pipeline guide features descriptive drug profiles for the pipeline products which comprise, product description, descriptive licensing and collaboration details, R&D brief, MoA & other developmental activities.

The pipeline guide reviews key companies involved in Bone Marrow Transplant Rejection (Immunology) therapeutics and enlists all their major and minor projects.

The pipeline guide evaluates Bone Marrow Transplant Rejection (Immunology) therapeutics based on mechanism of action (MoA), drug target, route of administration (RoA) and molecule type.

The pipeline guide encapsulates all the dormant and discontinued pipeline projects.

The pipeline guide reviews latest news related to pipeline therapeutics for Bone Marrow Transplant Rejection (Immunology)

Reasons to buy

Procure strategically important competitor information, analysis, and insights to formulate effective R&D strategies.

Recognize emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage.

Find and recognize significant and varied types of therapeutics under development for Bone Marrow Transplant Rejection (Immunology).

Classify potential new clients or partners in the target demographic.

Develop tactical initiatives by understanding the focus areas of leading companies.

Plan mergers and acquisitions meritoriously by identifying key players and it's most promising pipeline therapeutics.

Formulate corrective measures for pipeline projects by understanding Bone Marrow Transplant Rejection (Immunology) pipeline depth and focus of Indication therapeutics.

Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope.

Adjust the therapeutic portfolio by recognizing discontinued projects and understand from the know-how what drove them from pipeline.



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Contact Us:
Ken Research
Ankur Gupta, Head Marketing & Communications

+91-9015378249

Table of Contents

Table of Contents 2

List of Tables 7

List of Figures 9

Introduction 10

Global Markets Direct Report Coverage 10

Bone Marrow Transplant Rejection-Overview 11

Bone Marrow Transplant Rejection-Therapeutics Development 12

Pipeline Overview 12

Pipeline by Companies 13

Pipeline by Universities/Institutes 19

Products under Development by Companies 22

Products under Development by Universities/Institutes 28

Bone Marrow Transplant Rejection-Therapeutics Assessment 30

Assessment by Target 30

Assessment by Mechanism of Action 35

Assessment by Route of Administration 40

Assessment by Molecule Type 42

Bone Marrow Transplant Rejection-Companies Involved in Therapeutics Development 44

AbbVie Inc 44

AbGenomics International Inc 44

Actelion Ltd 45

Alexion Pharmaceuticals Inc 45

Allergan Plc 46

Amunix Operating Inc 46

AnaptysBio Inc 47

apceth Biopharma GmbH 47

Aptevo Therapeutics Inc 48

arGEN-X BV 48

Athersys Inc 49

Bellicum Pharmaceuticals Inc 49

Bio-Cancer Treatment International Ltd 50

Biogen Inc 50

Bristol-Myers Squibb Company 51

Cantex Pharmaceuticals Inc 51

Capricor Therapeutics Inc 52

Cell Source Inc 52

Cell2B Advanced Therapeutics SA 53

CellECT Bio Inc 53

Cleveland BioLabs Inc 54

Compugen Ltd 54

Cynata Therapeutics Limited 55

Cytodyn Inc 55

Dompe Farmaceutici SpA 56

Dr. Falk Pharma GmbH 56

Escape Therapeutics Inc 57

F. Hoffmann-La Roche Ltd 57

Fate Therapeutics Inc 58

Generon (Shanghai) Corp Ltd 58

Gilead Sciences Inc 59

GlaxoSmithKline Plc 59

Immunomedics Inc 60

Incyte Corp 60

Jazz Pharmaceuticals Plc 61

Kadmon Corp LLC 61

Kamada Ltd 62

Kiadis Pharma NV 62

Kymab Ltd 63

Kyorin Pharmaceutical Co Ltd 63

MacroGenics Inc 64

Mallinckrodt Plc 64

Medsenic 65

Mesoblast Ltd 65

Millennium Pharmaceuticals Inc 66

Nektar Therapeutics 66

Neovii Pharmaceuticals AG 67

Nohla Therapeutics Inc 67

Novartis AG 68

OncoImmune Inc 68

OSE Immunotherapeutics 69

Pfizer Inc 69

Pharmicell Co Ltd 70

Pluristem Therapeutics Inc 70

REGiMMUNE Corp 71

Sanofi 71

Sarepta Therapeutics Inc 72

Seattle Genetics Inc 72

Seres Therapeutics Inc 73

Sigmoid Pharma Ltd 73

Synedgen Inc 74

Taiga Biotechnologies Inc 74

Takeda Pharmaceutical Company Ltd 75

Targazyme Inc 75

United BioPharma Inc 76

Vault Pharma Inc 76

VBI Vaccines Inc 77

Xenikos BV 77

XL-protein GmbH 78

ZIOPHARM Oncology Inc 78

Bone Marrow Transplant Rejection-Drug Profiles 79

abatacept-Drug Profile 79

AbGn-168H-Drug Profile 87

AGS-499-Drug Profile 89

aldesleukin-Drug Profile 90

Alecmestencel-L-Drug Profile 92

alpha-1 proteinase inhibitor (human)-Drug Profile 93

ALXN-1007-Drug Profile 99

AMX-342-Drug Profile 101

anti-thymocyte globulin (rabbit)-Drug Profile 102

Antisense Oligonucleotide to Inhibit TLRs for Systemic Lupus Erythematosus and Graft Versus Host Disease-Drug Profile 104

ARGX-115-Drug Profile 105

arsenic trioxide-Drug Profile 106

ATIR-101-Drug Profile 107

BCT-200-Drug Profile 112

begelomab-Drug Profile 113

Biologic to Activate IL-2 for Graft Versus Host Disease-Drug Profile 114

Biologics for Graft Versus Host Disease-Drug Profile 115

bortezomib-Drug Profile 116

brentuximab vedotin-Drug Profile 124

budesonide-Drug Profile 151

C-87-Drug Profile 155

cannabidiol-Drug Profile 156

CAP-2003-Drug Profile 159

CBLB-612-Drug Profile 161

CD-24Fc-Drug Profile 163

Cell Therapy for Graft Versus Host Disease-Drug Profile 165

Cell Therapy for Graft-Versus Host Disease-Drug Profile 166

Cellgram for Graft Versus Host Disease-Drug Profile 167

Cellular Immunotherapy for Acute Graft Versus Host Disease-Drug Profile 168

Cellular Immunotherapy for Autoimmune Diseases and Transplantation-Drug Profile 169

Cellular Immunotherapy for Bone Marrow Transplantation-Drug Profile 171

Cellular Immunotherapy for Graft Versus Host Disease-Drug Profile 172

Cellular Immunotherapy for Graft Versus Host Disease-Drug Profile 173

Cellular Immunotherapy for Graft Versus Host Disease-Drug Profile 174

Cellular Immunotherapy for Graft Versus Host Disease-Drug Profile 175

Cellular Immunotherapy for Graft Versus Host Disease-Drug Profile 176

Cellular Immunotherapy for Graft Versus Host Disease-Drug Profile 177

Cellular Immunotherapy for Graft Versus Host Disease and Multiple Myeloma-Drug Profile 178

cenicriviroc mesylate-Drug Profile 179

CGEN-15001-Drug Profile 187

CRCBT-080004-Drug Profile 190

cyclosporine CR + cyclosporine IR-Drug Profile 191

CYP-001-Drug Profile 192

defibrotide sodium-Drug Profile 194

dociparstat sodium-Drug Profile 203

Echinomycin-Drug Profile 205

entospletinib-Drug Profile 206

ENTXA-2-Drug Profile 208

ES-210-Drug Profile 209

F-652-Drug Profile 210

FR-104-Drug Profile 212

Ha-7-Drug Profile 215

HE-33-Drug Profile 216

ibrutinib-Drug Profile 217

ImmuneSafe-Drug Profile 246

ImmuStem-Drug Profile 247

INX-021-Drug Profile 248

IT-603-Drug Profile 250

IT-901-Drug Profile 251

itacitinib adipate-Drug Profile 253

ixazomib citrate-Drug Profile 256

KD-025-Drug Profile 266

KRP-203-Drug Profile 271

KY-1005-Drug Profile 273

MAX-16H5-Drug Profile 274

MesoStem-Drug Profile 275

methoxsalen-Drug Profile 276

MGD-010-Drug Profile 278

milatuzumab-Drug Profile 281

Monoclonal Antibody for Graft Versus Host Disease and Inflammation-Drug Profile 284

Monoclonal Antibody to Activate BTLA for GVHD-Drug Profile 285

Monoclonal Antibody to Inhibit T-Bet for Immunology and Oncology-Drug Profile 286

MPC-CBE-Drug Profile 287

natalizumab-Drug Profile 289

nilotinib-Drug Profile 294

NKTR-358-Drug Profile 301

obinutuzumab-Drug Profile 302

OCU-300-Drug Profile 310

Oligonucleotide to Inhibit NFAT1 for GVHD-Drug Profile 311

panobinostat-Drug Profile 312

PF-05285401-Drug Profile 320

PLXR-18-Drug Profile 332

ponesimod-Drug Profile 339

Preimplantation Factor-Drug Profile 342

PRO-140-Drug Profile 344

ProTmune-Drug Profile 353

PTX-15-Drug Profile 355

Recombinant Protein for Graft Versus Host Disease and Autoimmune Disorders-Drug Profile 356

Recombinant Protein to Antagonize CCR8 for Graft Versus Host Disease and Multiple Sclerosis-Drug Profile 357

Recombinant Protein to Antagonize ILT3 for Graft Versus Host Disease-Drug Profile 358

remestemcel-L-Drug Profile 359

reparixin-Drug Profile 365

RGI-2001-Drug Profile 368

rimiducid + rivogenlecleucel-Drug Profile 371

rituximab biobetter-Drug Profile 376

RO-2959-Drug Profile 377

rovalpituzumab tesirine-Drug Profile 378

ruxolitinib phosphate-Drug Profile 380

S-Graft-Drug Profile 395

SER-155-Drug Profile 396

sirolimus-Drug Profile 397

Small Molecule for Autoimmune Disorders, Graft Versus Host Disease and Hemophagocytic Lymphohistiocytosis-Drug Profile 399

Small Molecule to Agonize AhR for Type 1 Diabetes and Graft Versus Host Disease-Drug Profile 400

Small Molecules to Inhibit Perforin for Bone Marrow Transplantation-Drug Profile 401

Small Molecules to Inhibit SHIP1 for Oncology and Immunology-Drug Profile 402

Small Molecules to Selectively Inhibit ROCK2 for Autoimmune Disorders-Drug Profile 403

sonidegib phosphate-Drug Profile 404

Stem Cell Therapy for Genito Urinary System And Sex Hormone Diseases, Immunology, Metabolic Disorders, Oncology and Respiratory Disease-Drug Profile 409

SYGN-305-Drug Profile 410

Synthetic Peptide to Antagonize VIPR for Cytomegalovirus Infection and Graft Versus Host Disease-Drug Profile 411

T-Guard-Drug Profile 412

TBX-1400-Drug Profile 414

TM-5509-Drug Profile 415

TZ-101-Drug Profile 416

vedolizumab-Drug Profile 419

VPI-101-Drug Profile 426

XL-085-Drug Profile 427

ZL-1101-Drug Profile 428

Bone Marrow Transplant Rejection-Dormant Projects 429

Bone Marrow Transplant Rejection-Discontinued Products 433

Bone Marrow Transplant Rejection-Product Development Milestones 434

Featured News & Press Releases 434

Appendix 446

Methodology 446

Coverage 446

Secondary Research 446

Primary Research 446

Expert Panel Validation 446

Contact Us 446

Disclaimer 447

List of Figures

Number of Products under Development for Bone Marrow Transplant Rejection, H1 2017

Number of Products under Development by Companies, H1 2017

Number of Products under Development by Universities/Institutes, H1 2017

Number of Products by Top 10 Targets, H1 2017

Number of Products by Stage and Top 10 Targets, H1 2017

Number of Products by Top 10 Mechanism of Actions, H1 2017

Number of Products by Stage and Top 10 Mechanism of Actions, H1 2017

Number of Products by Routes of Administration, H1 2017

Number of Products by Stage and Routes of Administration, H1 2017

Number of Products by Top 10 Molecule Types, H1 2017

Number of Products by Stage and Top 10 Molecule Types, H1 2017

List of Tables

Number of Products under Development for Bone Marrow Transplant Rejection, H1 2017

Number of Products under Development by Companies, H1 2017

Number of Products under Development by Companies, H1 2017 (Contd..1), H1 2017

Number of Products under Development by Companies, H1 2017 (Contd..2), H1 2017

Number of Products under Development by Companies, H1 2017 (Contd..3), H1 2017

Number of Products under Development by Companies, H1 2017 (Contd..4), H1 2017

Number of Products under Development by Universities/Institutes, H1 2017

Number of Products under Development by Universities/Institutes, H1 2017 (Contd..1), H1 2017

Products under Development by Companies, H1 2017

Products under Development by Companies, H1 2017 (Contd..1), H1 2017

Products under Development by Companies, H1 2017 (Contd..2), H1 2017

Products under Development by Companies, H1 2017 (Contd..3), H1 2017

Products under Development by Companies, H1 2017 (Contd..4), H1 2017

Products under Development by Companies, H1 2017 (Contd..5), H1 2017

Products under Development by Universities/Institutes, H1 2017

Products under Development by Universities/Institutes, H1 2017 (Contd..1), H1 2017

Number of Products by Stage and Target, H1 2017

Number of Products by Stage and Target, H1 2017 (Contd..1), H1 2017

Number of Products by Stage and Target, H1 2017 (Contd..2), H1 2017

Number of Products by Stage and Target, H1 2017 (Contd..3), H1 2017

Number of Products by Stage and Mechanism of Action, H1 2017

Number of Products by Stage and Mechanism of Action, H1 2017 (Contd..1), H1 2017

Number of Products by Stage and Mechanism of Action, H1 2017 (Contd..2), H1 2017

Number of Products by Stage and Mechanism of Action, H1 2017 (Contd..3), H1 2017

Number of Products by Stage and Route of Administration, H1 2017

Number of Products by Stage and Molecule Type, H1 2017

Bone Marrow Transplant Rejection-Pipeline by AbbVie Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by AbGenomics International Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Actelion Ltd, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Alexion Pharmaceuticals Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Allergan Plc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Amunix Operating Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by AnaptysBio Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by apceth Biopharma GmbH, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Aptevo Therapeutics Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by arGEN-X BV, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Athersys Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Bellicum Pharmaceuticals Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Bio-Cancer Treatment International Ltd, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Biogen Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Bristol-Myers Squibb Company, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Cantex Pharmaceuticals Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Capricor Therapeutics Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Cell Source Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Cell2B Advanced Therapeutics SA, H1 2017

Bone Marrow Transplant Rejection-Pipeline by CellECT Bio Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Cleveland BioLabs Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Compugen Ltd, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Cynata Therapeutics Limited, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Cytodyn Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Dompe Farmaceutici SpA, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Dr. Falk Pharma GmbH, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Escape Therapeutics Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by F. Hoffmann-La Roche Ltd, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Fate Therapeutics Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Generon (Shanghai) Corp Ltd, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Gilead Sciences Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by GlaxoSmithKline Plc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Immunomedics Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Incyte Corp, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Jazz Pharmaceuticals Plc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Kadmon Corp LLC, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Kamada Ltd, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Kiadis Pharma NV, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Kymab Ltd, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Kyorin Pharmaceutical Co Ltd, H1 2017

Bone Marrow Transplant Rejection-Pipeline by MacroGenics Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Mallinckrodt Plc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Medsenic, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Mesoblast Ltd, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Millennium Pharmaceuticals Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Nektar Therapeutics, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Neovii Pharmaceuticals AG, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Nohla Therapeutics Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Novartis AG, H1 2017

Bone Marrow Transplant Rejection-Pipeline by OncoImmune Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by OSE Immunotherapeutics, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Pfizer Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Pharmicell Co Ltd, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Pluristem Therapeutics Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by REGiMMUNE Corp, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Sanofi, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Sarepta Therapeutics Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Seattle Genetics Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Seres Therapeutics Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Sigmoid Pharma Ltd, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Synedgen Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Taiga Biotechnologies Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Takeda Pharmaceutical Company Ltd, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Targazyme Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by United BioPharma Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Vault Pharma Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by VBI Vaccines Inc, H1 2017

Bone Marrow Transplant Rejection-Pipeline by Xenikos BV, H1 2017

Bone Marrow Transplant Rejection-Pipeline by XL-protein GmbH, H1 2017

Bone Marrow Transplant Rejection-Pipeline by ZIOPHARM Oncology Inc, H1 2017

Bone Marrow Transplant Rejection-Dormant Projects, H1 2017

Bone Marrow Transplant Rejection-Dormant Projects, H1 2017 (Contd..1), H1 2017

Bone Marrow Transplant Rejection-Dormant Projects, H1 2017 (Contd..2), H1 2017

Bone Marrow Transplant Rejection-Dormant Projects, H1 2017 (Contd..3), H1 2017

Bone Marrow Transplant Rejection-Discontinued Products, H1 2017

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Bone Marrow Transplant Rejection-Companies Involved in Therapeutics Development, AbbVie Inc

Bone Marrow Transplant Rejection Therapeutic Products under Development, Key Players in Bone Marrow Transplant Rejection Therapeutics, Bone Marrow Transplant Rejection Pipeline Overview, Bone Marrow Transplant Rejection Pipeline, Bone Marrow Transplant Rejection Pipeline Assessment

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