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Burkitt Lymphoma-Pipeline Review, H1 2015

Burkitt Lymphoma-Pipeline Review, H1 2015


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Executive Summary

Burkitt Lymphoma-Pipeline Review, H1 2015

Summary

Global Markets Direct's, 'Burkitt Lymphoma-Pipeline Review, H1 2015', provides an overview of the Burkitt Lymphoma's therapeutic pipeline.

This report provides comprehensive information on the therapeutic development for Burkitt Lymphoma, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Burkitt Lymphoma and special features on late-stage and discontinued projects.

Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis.

The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.

Scope

The report provides a snapshot of the global therapeutic landscape of Burkitt Lymphoma

The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities

The report reviews key players involved in the therapeutics development for Burkitt Lymphoma and enlists all their major and minor projects

The report summarizes all the dormant and discontinued pipeline projects

A review of the Burkitt Lymphoma products under development by companies and universities/research institutes based on information derived from company and industry-specific sources

Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages

A detailed assessment of monotherapy and combination therapy pipeline projects

Coverage of the Burkitt Lymphoma pipeline on the basis of target, MoA, route of administration and molecule type

Latest news and deals relating related to pipeline products

Reasons To Buy

Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies

Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage

Develop strategic initiatives by understanding the focus areas of leading companies

Identify and understand important and diverse types of therapeutics under development for Burkitt Lymphoma

Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline

Devise corrective measures for pipeline projects by understanding Burkitt Lymphoma pipeline depth and focus of Indication therapeutics

Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline

Table of Contents

Table of Contents 2

List of Tables 4

List of Figures 4

Introduction 5

Global Markets Direct Report Coverage 5

Burkitt Lymphoma Overview 6

Therapeutics Development 7

Pipeline Products for Burkitt Lymphoma-Overview 7

Pipeline Products for Burkitt Lymphoma-Comparative Analysis 8

Burkitt Lymphoma-Therapeutics under Development by Companies 9

Burkitt Lymphoma-Therapeutics under Investigation by Universities/Institutes 10

Burkitt Lymphoma-Pipeline Products Glance 11

Clinical Stage Products 11

Early Stage Products 12

Burkitt Lymphoma-Products under Development by Companies 13

Burkitt Lymphoma-Products under Investigation by Universities/Institutes 14

Burkitt Lymphoma-Companies Involved in Therapeutics Development 15

AstraZeneca PLC 15

Constellation Pharmaceuticals, Inc. 16

Karyopharm Therapeutics, Inc. 17

Millennium Pharmaceuticals, Inc. 18

Pharmacyclics, Inc. 19

Seattle Genetics, Inc. 20

Burkitt Lymphoma-Therapeutics Assessment 21

Assessment by Monotherapy Products 21

Assessment by Target 22

Assessment by Mechanism of Action 24

Assessment by Route of Administration 26

Assessment by Molecule Type 28

Drug Profiles 30

alisertib-Drug Profile 30

Product Description 30

Mechanism of Action 30

R&D Progress 30

AZD-6738-Drug Profile 34

Product Description 34

Mechanism of Action 34

R&D Progress 34

denintuzumab mafodotin-Drug Profile 35

Product Description 35

Mechanism of Action 35

R&D Progress 35

ibrutinib-Drug Profile 36

Product Description 36

Mechanism of Action 36

R&D Progress 36

Monoclonal Antibody Conjugated to Target CD20 for Leukemia and Burkitt Lymphoma-Drug Profile 43

Product Description 43

Mechanism of Action 43

R&D Progress 43

selinexor-Drug Profile 44

Product Description 44

Mechanism of Action 44

R&D Progress 44

SH-7129-Drug Profile 49

Product Description 49

Mechanism of Action 49

R&D Progress 49

SH-7133-Drug Profile 51

Product Description 51

Mechanism of Action 51

R&D Progress 51

SH-7139-Drug Profile 52

Product Description 52

Mechanism of Action 52

R&D Progress 52

Small Molecules to Inhibit BET for Cancer-Drug Profile 54

Product Description 54

Mechanism of Action 54

R&D Progress 54

Burkitt Lymphoma-Recent Pipeline Updates 55

Appendix 82

Methodology 82

Coverage 82

Secondary Research 82

Primary Research 82

Expert Panel Validation 82

Contact Us 82

Disclaimer 83

List of Tables

Number of Products under Development for Burkitt Lymphoma, H1 2015 7

Number of Products under Development for Burkitt Lymphoma-Comparative Analysis, H1 2015 8

Number of Products under Development by Companies, H1 2015 9

Number of Products under Investigation by Universities/Institutes, H1 2015 10

Comparative Analysis by Clinical Stage Development, H1 2015 11

Comparative Analysis by Early Stage Development, H1 2015 12

Products under Development by Companies, H1 2015 13

Products under Investigation by Universities/Institutes, H1 2015 14

Burkitt Lymphoma-Pipeline by AstraZeneca PLC, H1 2015 15

Burkitt Lymphoma-Pipeline by Constellation Pharmaceuticals, Inc., H1 2015 16

Burkitt Lymphoma-Pipeline by Karyopharm Therapeutics, Inc., H1 2015 17

Burkitt Lymphoma-Pipeline by Millennium Pharmaceuticals, Inc., H1 2015 18

Burkitt Lymphoma-Pipeline by Pharmacyclics, Inc., H1 2015 19

Burkitt Lymphoma-Pipeline by Seattle Genetics, Inc., H1 2015 20

Assessment by Monotherapy Products, H1 2015 21

Number of Products by Stage and Target, H1 2015 23

Number of Products by Stage and Mechanism of Action, H1 2015 25

Number of Products by Stage and Route of Administration, H1 2015 27

Number of Products by Stage and Molecule Type, H1 2015 29

Burkitt Lymphoma Therapeutics-Recent Pipeline Updates, H1 2015 55

List of Figures

Number of Products under Development for Burkitt Lymphoma, H1 2015 7

Number of Products under Development for Burkitt Lymphoma-Comparative Analysis, H1 2015 8

Number of Products under Development by Companies, H1 2015 9

Comparative Analysis by Clinical Stage Development, H1 2015 11

Comparative Analysis by Early Stage Products, H1 2015 12

Assessment by Monotherapy Products, H1 2015 21

Number of Products by Top 10 Targets, H1 2015 22

Number of Products by Stage and Top 10 Targets, H1 2015 23

Number of Products by Top 10 Mechanism of Actions, H1 2015 24

Number of Products by Stage and Top 10 Mechanism of Actions, H1 2015 25

Number of Products by Top 10 Routes of Administration, H1 2015 26

Number of Products by Stage and Top 10 Routes of Administration, H1 2015 27

Number of Products by Top 10 Molecule Types, H1 2015 28

Number of Products by Stage and Top 10 Molecule Types, H1 2015 29

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AstraZeneca PLC

Constellation Pharmaceuticals, Inc.

Karyopharm Therapeutics, Inc.

Millennium Pharmaceuticals, Inc.

Pharmacyclics, Inc.

Seattle Genetics, Inc.

Burkitt Lymphoma Therapeutic Products under Development, Key Players in Burkitt Lymphoma Therapeutics, Burkitt Lymphoma Pipeline Overview, Burkitt Lymphoma Pipeline, Burkitt Lymphoma Pipeline Assessment


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