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Dengue-Pipeline Review, H2 2015

Dengue-Pipeline Review, H2 2015


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Executive Summary

Dengue-Pipeline Review, H2 2015

Summary

Global Markets Direct's, 'Dengue-Pipeline Review, H2 2015', provides an overview of the Dengue's therapeutic pipeline.

This report provides comprehensive information on the therapeutic development for Dengue, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Dengue and special features on late-stage and discontinued projects.

Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis.

The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.

Scope

The report provides a snapshot of the global therapeutic landscape of Dengue

The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities

The report reviews key players involved in the therapeutics development for Dengue

and enlists all their major and minor projects

The report summarizes all the dormant and discontinued pipeline projects

A review of the Dengue

products under development by companies and universities/research institutes based on information derived from company and industry-specific sources

Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages

A detailed assessment of monotherapy and combination therapy pipeline projects

Coverage of the Dengue

pipeline on the basis of target, MoA, route of administration and molecule type

Latest news and deals relating related to pipeline products

Reasons To Buy

Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies

Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage

Develop strategic initiatives by understanding the focus areas of leading companies

Identify and understand important and diverse types of therapeutics under development for Dengue

Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline

Devise corrective measures for pipeline projects by understanding Dengue

pipeline depth and focus of Indication therapeutics

Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline

Table of Contents

Table of Contents 2

List of Tables 6

List of Figures 7

Introduction 8

Global Markets Direct Report Coverage 8

Dengue Overview 9

Therapeutics Development 10

Pipeline Products for Dengue-Overview 10

Pipeline Products for Dengue-Comparative Analysis 11

Dengue-Therapeutics under Development by Companies 12

Dengue-Therapeutics under Investigation by Universities/Institutes 17

Dengue-Pipeline Products Glance 19

Late Stage Products 19

Clinical Stage Products 20

Early Stage Products 21

Dengue-Products under Development by Companies 22

Dengue-Products under Investigation by Universities/Institutes 26

Dengue-Companies Involved in Therapeutics Development 28

Abivax S.A. 28

Agilvax, Inc. 29

AltraVax Inc. 30

Arbovax, Inc. 31

BCI Pharma 32

BioDiem Ltd 33

Bioneer Corporation 34

Biotron Limited 35

CalAsia Pharmaceuticals, Inc. 36

Canopus BioPharma Incorporated 37

Cocrystal Pharma, Inc. 38

Codagenix, Inc. 39

GlaxoSmithKline Plc 40

Humabs BioMed SA 41

Immunotope, Inc. 42

Immunovaccine, Inc. 43

Inovio Pharmaceuticals, Inc. 44

Johnson & Johnson 45

Kineta, Inc. 46

Merck & Co., Inc. 47

Molplex Ltd. 48

Myelo Therapeutics GmbH 49

NanoViricides, Inc. 50

Panacea Biotec Limited 51

PaxVax 52

Prosetta Antiviral Inc. 53

Sanofi Pasteur SA 54

Sarepta Therapeutics, Inc. 55

SIGA Technologies, Inc. 56

SKAU Vaccines ApS 57

Takeda Pharmaceutical Company Limited 58

TechnoVax, Inc. 59

Tekmira Pharmaceuticals Corp. 60

Themis Bioscience GmbH 61

United Therapeutics Corporation 62

VaxInnate Corporation 63

Visterra, Inc. 64

Dengue-Therapeutics Assessment 65

Assessment by Monotherapy Products 65

Assessment by Target 66

Assessment by Mechanism of Action 68

Assessment by Route of Administration 70

Assessment by Molecule Type 72

Drug Profiles 74

ABX-220-Drug Profile 74

Antisense RNAi Oligonucleotide for Dengue-Drug Profile 75

BG-323-Drug Profile 76

CB-010-Drug Profile 77

celgosivir hydrochloride-Drug Profile 78

dengue (serotype DEN-2) vaccine-Drug Profile 79

dengue (tetravalent) vaccine-Drug Profile 80

dengue (tetravalent) vaccine-Drug Profile 81

dengue (tetravalent) vaccine-Drug Profile 83

dengue (tetravalent) vaccine-Drug Profile 84

dengue (tetravalent) vaccine-Drug Profile 85

dengue (tetravalent) vaccine-Drug Profile 86

dengue (tetravalent) vaccine-Drug Profile 87

dengue (tetravalent) vaccine-Drug Profile 88

dengue (tetravalent) vaccine-Drug Profile 89

dengue (tetravalent) vaccine 3-Drug Profile 90

dengue (tetravalent) vaccine 4-Drug Profile 92

dengue (tetravalent) vaccines-Drug Profile 93

dengue [rDEN1delta30, rDEN2/4delta30(ME), rDEN3delta30/31 and rDEN4delta30] (tetravalent) vaccine-Drug Profile 94

dengue [serotype 2] vaccine-Drug Profile 95

dengue [serotype DEN-1, DEN-2] vaccine-Drug Profile 96

dengue [serotype DEN-1] vaccine-Drug Profile 97

dengue [serotype DENV-2] vaccine-Drug Profile 98

dengue [serotypes 1,2,3,4] (tetravalent) vaccine-Drug Profile 99

dengue [serotypes 1,2,3,4] (tetravalent) vaccine-Drug Profile 102

dengue [serotypes 1,2,3,4] (tetravalent) vaccine-Drug Profile 103

dengue [serotypes 1,3,4] (trivalent) vaccine-Drug Profile 104

dengue fever vaccine-Drug Profile 105

dengue vaccine-Drug Profile 106

dengue vaccine-Drug Profile 107

dengue vaccine-Drug Profile 108

dengue vaccine-Drug Profile 109

dengue vaccine 4-Drug Profile 110

dengue virus like particle vaccine-Drug Profile 111

DengueCide-Drug Profile 112

DiTU-Drug Profile 113

DV-2DeltaGVII-Drug Profile 114

DV-2DeltaLIG-Drug Profile 115

DV-2G460P-Drug Profile 116

ETX-101-Drug Profile 117

FDX-000-Drug Profile 118

fenretinide-Drug Profile 119

FX-06-Drug Profile 120

GBV-001-Drug Profile 122

GBV-006-Drug Profile 123

GREDEN/V1-4-Drug Profile 124

LCTA-949-Drug Profile 125

LVM-142-Drug Profile 126

modipafant-Drug Profile 127

Monoclonal Antibodies to Inhibit Virion, prM and E Proteins for Dengue-Drug Profile 128

Monoclonal Antibody for Dengue-Drug Profile 129

Monoclonal Antibody for Dengue-Drug Profile 130

Myelo-001-Drug Profile 131

PAV-866-Drug Profile 132

PY-2-Drug Profile 133

Recombinant Peptide to Inhibit Dengue Protease for Dengue-Drug Profile 134

rOAS-Drug Profile 135

RS-1137-Drug Profile 136

RS-1142-Drug Profile 137

RS-1145-Drug Profile 138

RS-930-Drug Profile 139

RS-961-Drug Profile 140

Small Molecule for Dengue-Drug Profile 141

Small Molecule for Dengue-Drug Profile 142

Small Molecule for Dengue-Drug Profile 143

Small Molecule to Agonize IRF-3 for Viral Infections-Drug Profile 144

Small Molecule to Inhibit NS2B-NS3 Protease for Dengue and West Nile Virus Infection-Drug Profile 145

Small Molecule to Inhibit NS3 Protease for Dengue and West Nile Virus Infections-Drug Profile 146

Small Molecule to Inhibit NS5 for Dengue and Flavivirus Infections-Drug Profile 147

Small Molecules for Dengue-Drug Profile 148

Small Molecules for Dengue-Drug Profile 149

Small Molecules Inhibiting M Protein for Dengue-Drug Profile 150

Small Molecules to Activate AMPK for Dengue-Drug Profile 151

Small Molecules to Inhibit Alpha-Glucosidase I and II for Viral Infections-Drug Profile 152

Small Molecules to Inhibit Furin for Dengue-Drug Profile 154

Small Molecules to Inhibit NS4B for Dengue-Drug Profile 155

Small Molecules to Inhibit Pan Polymerase for Dengue-Drug Profile 156

Small Molecules to Inhibit RNA Dependent RNA Polymerase for Dengue Virus Infections-Drug Profile 157

Small Molecules to Inhibit Serine Protease for Viral Infections-Drug Profile 158

ST-148-Drug Profile 159

ST-324-Drug Profile 161

ST-610-Drug Profile 162

Synthetic Peptide for West Nile Virus and Dengue Virus Infections-Drug Profile 163

TAK-003-Drug Profile 164

TDEN-PIV-Drug Profile 166

TVX-005-Drug Profile 167

UV-4B-Drug Profile 168

V-180-Drug Profile 169

Viral PMO-X-Drug Profile 171

VIS-513-Drug Profile 172

Dengue-Recent Pipeline Updates 173

Dengue-Dormant Projects 179

Dengue-Discontinued Products 183

Dengue-Product Development Milestones 184

Featured News & Press Releases 184

Appendix 196

Methodology 196

Coverage 196

Secondary Research 196

Primary Research 196

Expert Panel Validation 196

Contact Us 196

Disclaimer 197

List of Tables

Number of Products under Development for Dengue, H2 2015 17

Number of Products under Development for Dengue-Comparative Analysis, H2 2015 18

Number of Products under Development by Companies, H2 2015 20

Number of Products under Development by Companies, H2 2015 (Contd..1) 21

Number of Products under Development by Companies, H2 2015 (Contd..2) 22

Number of Products under Development by Companies, H2 2015 (Contd..3) 23

Number of Products under Investigation by Universities/Institutes, H2 2015 25

Comparative Analysis by Late Stage Development, H2 2015 26

Comparative Analysis by Clinical Stage Development, H2 2015 27

Comparative Analysis by Early Stage Development, H2 2015 28

Products under Development by Companies, H2 2015 29

Products under Development by Companies, H2 2015 (Contd..1) 30

Products under Development by Companies, H2 2015 (Contd..2) 31

Products under Development by Companies, H2 2015 (Contd..3) 32

Products under Investigation by Universities/Institutes, H2 2015 33

Products under Investigation by Universities/Institutes, H2 2015 (Contd..1) 34

Dengue-Pipeline by Abivax S.A., H2 2015 35

Dengue-Pipeline by Agilvax, Inc., H2 2015 36

Dengue-Pipeline by AltraVax Inc., H2 2015 37

Dengue-Pipeline by Arbovax, Inc., H2 2015 38

Dengue-Pipeline by BCI Pharma, H2 2015 39

Dengue-Pipeline by BioDiem Ltd, H2 2015 40

Dengue-Pipeline by Bioneer Corporation, H2 2015 41

Dengue-Pipeline by Biotron Limited, H2 2015 42

Dengue-Pipeline by CalAsia Pharmaceuticals, Inc., H2 2015 43

Dengue-Pipeline by Canopus BioPharma Incorporated, H2 2015 44

Dengue-Pipeline by Cocrystal Pharma, Inc., H2 2015 45

Dengue-Pipeline by Codagenix, Inc., H2 2015 46

Dengue-Pipeline by GlaxoSmithKline Plc, H2 2015 47

Dengue-Pipeline by Humabs BioMed SA, H2 2015 48

Dengue-Pipeline by Immunotope, Inc., H2 2015 49

Dengue-Pipeline by Immunovaccine, Inc., H2 2015 50

Dengue-Pipeline by Inovio Pharmaceuticals, Inc., H2 2015 51

Dengue-Pipeline by Johnson & Johnson, H2 2015 52

Dengue-Pipeline by Kineta, Inc., H2 2015 53

Dengue-Pipeline by Merck & Co., Inc., H2 2015 54

Dengue-Pipeline by Molplex Ltd., H2 2015 55

Dengue-Pipeline by Myelo Therapeutics GmbH, H2 2015 56

Dengue-Pipeline by NanoViricides, Inc., H2 2015 57

Dengue-Pipeline by Panacea Biotec Limited, H2 2015 58

Dengue-Pipeline by PaxVax, H2 2015 59

Dengue-Pipeline by Prosetta Antiviral Inc., H2 2015 60

Dengue-Pipeline by Sanofi Pasteur SA, H2 2015 61

Dengue-Pipeline by Sarepta Therapeutics, Inc., H2 2015 62

Dengue-Pipeline by SIGA Technologies, Inc., H2 2015 63

Dengue-Pipeline by SKAU Vaccines ApS, H2 2015 64

Dengue-Pipeline by Takeda Pharmaceutical Company Limited, H2 2015 65

Dengue-Pipeline by TechnoVax, Inc., H2 2015 66

Dengue-Pipeline by Tekmira Pharmaceuticals Corp., H2 2015 67

Dengue-Pipeline by Themis Bioscience GmbH, H2 2015 68

Dengue-Pipeline by United Therapeutics Corporation, H2 2015 69

Dengue-Pipeline by VaxInnate Corporation, H2 2015 70

Dengue-Pipeline by Visterra, Inc., H2 2015 71

Assessment by Monotherapy Products, H2 2015 72

Number of Products by Stage and Target, H2 2015 74

Number of Products by Stage and Mechanism of Action, H2 2015 76

Number of Products by Stage and Route of Administration, H2 2015 78

Number of Products by Stage and Molecule Type, H2 2015 80

Dengue Therapeutics-Recent Pipeline Updates, H2 2015 180

Dengue-Dormant Projects, H2 2015 186

Dengue-Dormant Projects (Contd..1), H2 2015 187

Dengue-Dormant Projects (Contd..2), H2 2015 188

Dengue-Dormant Projects (Contd..3), H2 2015 189

Dengue-Discontinued Products, H2 2015 190

List of Figures

Number of Products under Development for Dengue, H2 2015 17

Number of Products under Development for Dengue-Comparative Analysis, H2 2015 18

Number of Products under Development by Companies, H2 2015 19

Number of Products under Investigation by Universities/Institutes, H2 2015 24

Comparative Analysis by Late Stage Development, H2 2015 26

Comparative Analysis by Clinical Stage Development, H2 2015 27

Comparative Analysis by Early Stage Products, H2 2015 28

Assessment by Monotherapy Products, H2 2015 72

Number of Products by Top 10 Targets, H2 2015 73

Number of Products by Stage and Top 10 Targets, H2 2015 73

Number of Products by Top 10 Mechanism of Actions, H2 2015 75

Number of Products by Stage and Top 10 Mechanism of Actions, H2 2015 75

Number of Products by Top 10 Routes of Administration, H2 2015 77

Number of Products by Stage and Top 10 Routes of Administration, H2 2015 77

Number of Products by Top 10 Molecule Types, H2 2015 79

Number of Products by Stage and Top 10 Molecule Types, H2 2015 79

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Abivax S.A.

Agilvax, Inc.

AltraVax Inc.

Arbovax, Inc.

BCI Pharma

BioDiem Ltd

Bioneer Corporation

Biotron Limited

CalAsia Pharmaceuticals, Inc.

Canopus BioPharma Incorporated

Cocrystal Pharma, Inc.

Codagenix, Inc.

GlaxoSmithKline Plc

Humabs BioMed SA

Immunotope, Inc.

Immunovaccine, Inc.

Inovio Pharmaceuticals, Inc.

Johnson & Johnson

Kineta, Inc.

Merck & Co., Inc.

Molplex Ltd.

Myelo Therapeutics GmbH

NanoViricides, Inc.

Panacea Biotec Limited

PaxVax

Prosetta Antiviral Inc.

Sanofi Pasteur SA

Sarepta Therapeutics, Inc.

SIGA Technologies, Inc.

SKAU Vaccines ApS

Takeda Pharmaceutical Company Limited

TechnoVax, Inc.

Tekmira Pharmaceuticals Corp.

Themis Bioscience GmbH

United Therapeutics Corporation

VaxInnate Corporation

Visterra, Inc.

ngue - Therapeutics Assessment

Dengue Therapeutic Products under Development, Key Players in Dengue Therapeutics, Dengue Pipeline Overview, Dengue Pipeline, Dengue Pipeline Assessment


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