EpiCast Report: Sepsis and Septic Shock-Epidemiology Forecast to 2026

EpiCast Report: Sepsis and Septic Shock-Epidemiology Forecast to 2026


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Executive Summary

EpiCast Report: Sepsis and Septic Shock-Epidemiology Forecast to 2026

Summary

Sepsis is a life-threatening complication arising from an infection, which occurs when the body's response to the infection damages its own tissues and organs. Sepsis can lead to multiple organ failure and death, especially if it is not recognized early and treated promptly. Anyone can develop sepsis; however, the condition is more common among children less than one year of age, older adults, and those with weakened immune systems. Although any type of infection (bacterial, viral, or fungal) can lead to sepsis, people suffering from pneumonia, abdominal infection, kidney infection, and bloodstream infection (bacteremia) are more likely to develop sepsis. The most common pathogens for sepsis include bacteria (gram-positive, gram-negative), fungi, viruses, and parasites.

To forecast the diagnosed incident cases of sepsis and septic shock in the 7MM, GlobalData epidemiologists selected nationally representative population-based studies that provided diagnosed incidence and/or mortality rate of sepsis and septic shock in the 7MM. Additionally, the diagnostic criteria for sepsis and septic shock are based on the sepsis-3 definition across all 7MM in this analysis.

GlobalData epidemiologists forecast that the diagnosed incident cases of sepsis in the 7MM will grow at an Annual Growth Rate (AGR) of 2.06% per year over the next 10 years, from 2,594,665 cases in 2016 to 3,129,753 cases in 2026. GlobalData epidemiologists forecast that the diagnosed incident cases of septic shock in the 7MM will grow by an AGR of 2.07% per year over the next 10 years, from 539,085 cases in 2016 to 650,426 cases in 2026. The US will have the highest incident cases of sepsis and septic shock in the 7MM throughout the forecast period, while Japan had the lowest.

Scope

The Sepsis and Septic Shock EpiCast Report provides an overview of the risk factors and global trends of sepsis and septic shock in the seven major markets (7MM: US, France, Germany, Italy, Spain, UK, and Japan). It includes a 10-year epidemiological forecast for the diagnosed incident cases of sepsis and septic shock, segmented by age (for all ages) and sex. The sepsis and septic shock diagnosed incident cases are further segmented by causative agent and organ dysfunction. Additionally, GlobalData epidemiologists provide a forecast for the in-hospital mortality cases of sepsis and septic shock, segmented by age for both sexes.

The sepsis and septic shock epidemiology report is written and developed by Masters- and PhD-level epidemiologists.

The EpiCast Report is in-depth, high quality, transparent and market-driven, providing expert analysis of disease trends in the 7MM.

Reasons to buy

The Sepsis and Septic Shock EpiCast report will allow you to-

Develop business strategies by understanding the trends shaping and driving the global sepsis and septic shock market.

Quantify patient populations in the global sepsis and septic shock market to improve product design, pricing, and launch plans.

Organize sales and marketing efforts by identifying the age groups and sex that present the best opportunities for sepsis and septic shock therapeutics in each of the markets covered.

Understand the causative agent, organ dysfunction, and mortality of sepsis and septic shock.



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1 Table of Contents

1 Table of Contents 2

1.1 List of Tables 4

1.2 List of Figures 4

2 Executive Summary 5

2.1 Related Reports 7

2.2 Upcoming Reports 8

3 Epidemiology 9

3.1 Disease Background 9

3.2 Risk Factors and Comorbidities 10

3.3 Global and Historical Trends 11

3.4 Forecast Methodology 13

3.4.1 Sources 13

3.4.2 Forecast Assumptions and Methods 21

3.4.3 Diagnosed Incident Cases of Sepsis 21

3.4.4 Diagnosed Incident Cases of Septic Shock 24

3.4.5 Diagnosed Incident Cases of Sepsis/Septic Shock by Causative Agent 26

3.4.6 Organ Dysfunction among Diagnosed Incident Cases of Sepsis 29

3.4.7 Organ Dysfunction among Diagnosed Incident Cases of Septic Shock 31

3.4.8 Sepsis In-Hospital Mortality Cases 33

3.4.9 Septic Shock In-Hospital Mortality Cases 36

3.5 Epidemiological Forecast for Sepsis and Septic Shock (2016-2026) 38

3.5.1 Diagnosed Incident Cases of Sepsis 38

3.5.2 Age-Specific Diagnosed Incident Cases of Sepsis 39

3.5.3 Sex-Specific Diagnosed Incident Cases of Sepsis 40

3.5.4 Diagnosed Incident Cases of Sepsis by Causative Agent 41

3.5.5 Organ Dysfunction among Diagnosed Incident Cases of Sepsis 42

3.5.6 Sepsis In-Hospital Mortality Cases 43

3.5.7 Age-Specific In-Hospital Mortality Cases of Sepsis 44

3.5.8 Diagnosed Incident Cases of Septic Shock 45

3.5.9 Age-Specific Diagnosed Incident Cases of Septic Shock 46

3.5.10 Sex-Specific Diagnosed Incident Cases of Septic Shock 47

3.5.11 Diagnosed Incident Cases of Septic Shock by Causative Agent 48

3.5.12 Organ Dysfunction among Diagnosed Incident Cases of Septic Shock 49

3.5.13 Septic Shock In-Hospital Mortality Cases 50

3.5.14 Age-Specific In-Hospital Mortality Cases of Septic Shock 51

3.6 Discussion 52

3.6.1 Epidemiological Forecast Insight 52

3.6.2 Limitations of Analysis 53

3.6.3 Strengths of Analysis 53

4 Appendix 55

4.1 Bibliography 55

4.2 About the Authors 59

4.2.1 Epidemiologist 59

4.2.2 Reviewers 59

4.2.3 Global Director of Therapy Analysis and Epidemiology 60

4.2.4 Global Head and EVP of Healthcare Operations and Strategy 60

4.3 About GlobalData 61

4.4 Contact Us 61

4.5 Disclaimer 61

1.2 List of Figures

Figure 1: 7MM, Diagnosed Incident Cases of Sepsis, Both Sexes, All Ages, 2016 and 2026 6

Figure 2: 7MM, Diagnosed Incident Cases of Septic Shock, Both Sexes, All Ages, 2016 and 2026 7

Figure 3: 7MM, Age-Standardized Diagnosed Incidence of Sepsis (Cases per 100,000 Population), Both Sexes, All Ages, 2016 12

Figure 4: 7MM, Age-Standardized Diagnosed Incidence of Septic Shock (Cases per 100,000 Population), Both Sexes, All Ages, 2016 13

Figure 5: 7MM, Sources Used and Not Used, Diagnosed Incident Cases of Sepsis 15

Figure 6: 7MM, Sources Used and Not Used, Diagnosed Incident Cases of Sepsis/Septic Shock by Causative Agent 16

Figure 7: 7MM, Sources Used and Not Used, Organ Dysfunction among Sepsis Cases 17

Figure 8: 7MM, Sources Used and Not Used, In-Hospital Mortality Cases of Sepsis 18

Figure 9: 7MM, Sources Used and Not Used, Diagnosed Incident Cases of Septic Shock 19

Figure 10: 7MM, Sources Used and Not Used, Organ Dysfunction of Septic Shock Cases 20

Figure 11: 7MM, Sources Used, In-Hospital Mortality Cases of Septic Shock 21

Figure 12: 7MM, Age-Specific Diagnosed Incident Cases of Sepsis, Both Sexes, All Ages, 2016 39

Figure 13: 7MM, Sex-Specific Diagnosed Incident Cases of Sepsis, Both Sexes, All Ages, 2016 40

Figure 14: 7MM, Diagnosed Incident Cases of Sepsis by Causative Agent, Both Sexes, All Ages, 2016 41

Figure 15: 7MM, Organ Dysfunction among Diagnosed Incident Cases of Sepsis, Both Sexes, All Ages, 2016 42

Figure 16: 7MM, Age-Specific In-Hospital Mortality Cases of Sepsis, Both Sexes, All Ages, 2016 44

Figure 17: 7MM, Age-Specific Diagnosed Incident Cases of Septic Shock, Both Sexes, All Ages, 2016 46

Figure 18: 7MM, Sex-Specific Diagnosed Incident Cases of Septic Shock, Both Sexes, All Ages, 2016 47

Figure 19: 7MM, Diagnosed Incident Cases of Septic Shock by Causative Agent, Both Sexes, All Ages, 2016 48

Figure 20: 7MM, Organ Dysfunction among Diagnosed Incident Cases of Septic Shock, Both Sexes, All Ages, 2016 49

Figure 21: 7MM, Age-Specific In-Hospital Mortality Cases of Septic Shock, Both Sexes, All Ages, 2016 51

1.1 List of Tables

Table 1: Risk Factors and Comorbidities for Sepsis and Septic Shock 10

Table 2: 7MM, Diagnosed Incident Cases of Sepsis, Both Sexes, All Ages, Selected Years 2016-2026 38

Table 3: 7MM, Sepsis In-Hospital Mortality Cases, Both Sexes, All Ages, Selected Years 2016-2026 43

Table 4: 7MM, Diagnosed Incident Cases of Septic Shock, Both Sexes, All Ages, Selected Years 2016-2026 45

Table 5: 7MM, Septic Shock In-Hospital Mortality Cases, Both Sexes, All Ages, Selected Years 2016-2026 50

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