Hepatitis Drug Development Pipeline Review, 2017

Hepatitis Drug Development Pipeline Review, 2017


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Executive Summary

Hepatitis Drug Development Pipeline Review, 2017

Summary

This report provides an overview of the hepatitis pipeline landscape. The report provides comprehensive information on the therapeutics under development and key players involved in therapeutic development for hepatitis A, B, C and D, and features dormant and discontinued projects.

Hepatitis is a contagious viral infection affecting the liver, which may spread on contact with infected blood. It may be a mild condition or may extend over a longer span of time leading to various complications. The characteristic symptoms include abdominal pain, fatigue, fever, jaundice, loss of appetite, nausea and vomiting. The predisposing factors of hepatitis typically include dialysis, organ transplant and blood transfusion and the offspring of an infected mother also has high chances of contracting the disease.

Owing to differences in prevalence, hepatitis A and D have far smaller pipelines than hepatitis B and C; the size of these pipelines ranges from seven products in hepatitis A to 182 in hepatitis B and 199 in hepatitis C. Many of the companies who are actively fielding products in the larger two hepatitis subtypes are simultaneously developing products for both. While in hepatitis A, B and D, viral surface antigens and interferons are commonly targeted, a far wider range of proteins, including non-structural proteins, are the most common targets in hepatitis C.

Scope

Which companies are the most active within the pipeline for hepatitis therapeutics?

Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication?

To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies?

What are the most important R&D milestones and data publications to have happened in the field of hepatitis?

Reasons to buy

Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication

Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline program in each indication, and a comprehensive picture of recent updates and milestones for each

Analyze the companies, institutions and universities currently operating in the pipeline, and the products being fielded by each of these

Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration



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Contact Us:
Ken Research
Ankur Gupta, Head Marketing & Communications

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Table of Contents

GBI Research Report Guidance 2

Executive Summary 3

Table of Contents 4

List of Tables 6

List of Figures 11

Introduction 12

Hepatitis Report Coverage 12

Hepatitis A - Overview 12

Hepatitis B - Overview 12

Hepatitis C - Overview 12

Hepatitis D - Overview 12

Therapeutics Development 13

Hepatitis A 13

Hepatitis B 17

Hepatitis C 30

Hepatitis D 43

Therapeutics Assessment 46

Hepatitis A 46

Hepatitis B 48

Hepatitis C 56

Hepatitis D 65

Companies Involved in Therapeutics Development 72

Hepatitis A 72

Hepatitis B 74

Hepatitis C 116

Hepatitis D 151

Dormant Projects 155

Hepatitis A 155

Hepatitis B 155

Hepatitis C 159

Hepatitis D 169

Discontinued Products 170

Hepatitis B 170

Hepatitis C 170

Hepatitis D 173

Product Development Milestones 174

Hepatitis B 174

Hepatitis C 182

Hepatitis D 196

Appendix 208

Methodology 208

Coverage 208

Secondary Research 208

Primary Research 208

Expert Panel Validation 208

Contact Us 208

Disclaimer 209

List of Figures

Number of Products under Development for Hepatitis A 13

Number of Products under Development by Companies, Hepatitis A 14

Number of Products under Development by Universities/Institutes, Hepatitis A 15

Number of Products under Development for Hepatitis B 17

Number of Products under Development by Companies, Hepatitis B 18

Number of Products under Development by Universities/Institutes, Hepatitis B 22

Number of Products under Development for Hepatitis C 30

Number of Products under Development by Companies, Hepatitis C 31

Number of Products under Development by Universities/Institutes, Hepatitis C 34

Number of Products under Development for Hepatitis D 43

Number of Products under Development by Companies, Hepatitis D 44

Number of Products by Molecule Types, Hepatitis A 46

Number of Products by Stage and Molecule Types, Hepatitis A 47

Number of Products by Top 10 Targets, Hepatitis B 48

Number of Products by Stage and Top 10 Targets, Hepatitis B 48

Number of Products by Top 10 Mechanism of Actions, Hepatitis B 50

Number of Products by Stage and Top 10 Mechanism of Actions, Hepatitis B 50

Number of Products by Top 10 Routes of Administration, Hepatitis B 52

Number of Products by Stage and Top 10 Routes of Administration, Hepatitis B 52

Number of Products by Top 10 Molecule Types, Hepatitis B 54

Number of Products by Stage and Top 10 Molecule Types, Hepatitis B 54

Number of Products by Top 10 Targets, Hepatitis C 56

Number of Products by Stage and Top 10 Targets, Hepatitis C 56

Number of Products by Top 10 Mechanism of Actions, Hepatitis C 59

Number of Products by Stage and Top 10 Mechanism of Actions, Hepatitis C 59

Number of Products by Routes of Administration, Hepatitis C 62

Number of Products by Stage and Routes of Administration, Hepatitis C 62

Number of Products by Top 10 Molecule Types, Hepatitis C 64

Number of Products by Stage and Top 10 Molecule Types, Hepatitis C 64

Number of Products by Targets, Hepatitis D 65

Number of Products by Stage and Targets, Hepatitis D 66

Number of Products by Mechanism of Actions, Hepatitis D 67

Number of Products by Stage and Mechanism of Actions, Hepatitis D 67

Number of Products by Routes of Administration, Hepatitis D 69

Number of Products by Stage and Routes of Administration, Hepatitis D 69

Number of Products by Molecule Types, Hepatitis D 70

Number of Products by Stage and Molecule Types, Hepatitis D 71

List of Tables

Number of Products under Development for Hepatitis A 13

Number of Products under Development by Companies, Hepatitis A 14

Number of Products under Development by Universities/Institutes, Hepatitis A 15

Products under Development by Companies, Hepatitis A 16

Products under Development by Universities/Institutes, Hepatitis A 16

Number of Products under Development for Hepatitis B 17

Number of Products under Development by Companies, Hepatitis B 19

Number of Products under Development by Universities/Institutes, Hepatitis B 22

Products under Development by Companies, Hepatitis B 23

Products under Development by Universities/Institutes, Hepatitis B 29

Number of Products under Development for Hepatitis C 30

Number of Products under Development by Companies, Hepatitis C 32

Number of Products under Development by Universities/Institutes, Hepatitis C 35

Products under Development by Companies, Hepatitis C 36

Products under Development by Universities/Institutes, Hepatitis C 41

Number of Products under Development for Hepatitis D 43

Number of Products under Development by Companies, Hepatitis D 44

Number of Products under Development by Universities/Institutes, Hepatitis D 45

Products under Development by Companies, Hepatitis D 45

Products under Development by Universities/Institutes, Hepatitis D 45

Number of Products by Stage and Target, Hepatitis A 46

Number of Products by Stage and Molecule Type, Hepatitis A 47

Number of Products by Stage and Target, Hepatitis B 49

Number of Products by Stage and Mechanism of Action, Hepatitis B 51

Number of Products by Stage and Route of Administration, Hepatitis B 53

Number of Products by Stage and Molecule Type, Hepatitis B 55

Number of Products by Stage and Target, Hepatitis C 57

Number of Products by Stage and Mechanism of Action, Hepatitis C 60

Number of Products by Stage and Route of Administration, Hepatitis C 63

Number of Products by Stage and Molecule Type, Hepatitis C 65

Number of Products by Stage and Target, Hepatitis D 66

Number of Products by Stage and Mechanism of Action, Hepatitis D 68

Number of Products by Stage and Route of Administration, Hepatitis D 70

Number of Products by Stage and Molecule Type, Hepatitis D 71

Hepatitis A - Pipeline by Beijing Minhai Biotechnology Co Ltd 72

Hepatitis A - Pipeline by Indian Immunologicals Ltd 72

Hepatitis A - Pipeline by Sinovac Biotech Ltd 73

Hepatitis A - Pipeline by Zydus Cadila Healthcare Ltd 73

Hepatitis B - Pipeline by Abivax SA 74

Hepatitis B - Pipeline by AiCuris GmbH & Co KG 74

Hepatitis B - Pipeline by AIMM Therapeutics BV 75

Hepatitis B - Pipeline by Akshaya Bio Inc 75

Hepatitis B - Pipeline by Alnylam Pharmaceuticals Inc 76

Hepatitis B - Pipeline by Altimmune Inc 76

Hepatitis B - Pipeline by Altravax Inc 77

Hepatitis B - Pipeline by Amarna Therapeutics BV 77

Hepatitis B - Pipeline by Arbutus Biopharma Corp 78

Hepatitis B - Pipeline by Arcturus Therapeutics Inc 79

Hepatitis B - Pipeline by Arrowhead Pharmaceuticals Inc 79

Hepatitis B - Pipeline by Assembly Biosciences Inc 80

Hepatitis B - Pipeline by Beijing Kawin Technology Share-Holding Co Ltd 80

Hepatitis B - Pipeline by Beijing Minhai Biotechnology Co Ltd 81

Hepatitis B - Pipeline by Benitec Biopharma Ltd 81

Hepatitis B - Pipeline by Biological E Ltd 82

Hepatitis B - Pipeline by BioStar Pharmaceuticals Inc 82

Hepatitis B - Pipeline by Bolder Biotechnology Inc 83

Hepatitis B - Pipeline by BrightGene Bio-Medical Technology Co Ltd 83

Hepatitis B - Pipeline by Bukwang Pharm Co Ltd 84

Hepatitis B - Pipeline by CaroGen Corp 84

Hepatitis B - Pipeline by Celltrion Inc 85

Hepatitis B - Pipeline by Chong Kun Dang Pharmaceutical Corp 85

Hepatitis B - Pipeline by Chromis Therapeutics Inc 86

Hepatitis B - Pipeline by Cocrystal Pharma Inc 86

Hepatitis B - Pipeline by ContraVir Pharmaceuticals Inc 87

Hepatitis B - Pipeline by CyTuVax BV 87

Hepatitis B - Pipeline by Dicerna Pharmaceuticals Inc 88

Hepatitis B - Pipeline by Dong-A Socio Holdings Co Ltd 88

Hepatitis B - Pipeline by Dynavax Technologies Corp 89

Hepatitis B - Pipeline by Ensemble Therapeutics Corp 89

Hepatitis B - Pipeline by Enyo Pharma SA 90

Hepatitis B - Pipeline by eTheRNA Immunotherapies NV 90

Hepatitis B - Pipeline by F. Hoffmann-La Roche Ltd 91

Hepatitis B - Pipeline by GeneCure LLC 91

Hepatitis B - Pipeline by GeoVax Labs Inc 92

Hepatitis B - Pipeline by Gilead Sciences Inc 92

Hepatitis B - Pipeline by GlaxoSmithKline Plc 93

Hepatitis B - Pipeline by Green Cross Corp 93

Hepatitis B - Pipeline by Hanmi Pharmaceuticals Co Ltd 94

Hepatitis B - Pipeline by Humabs BioMed SA 94

Hepatitis B - Pipeline by Huons Co Ltd 95

Hepatitis B - Pipeline by Ildong Pharmaceutical Co Ltd 95

Hepatitis B - Pipeline by Immunotope Inc 96

Hepatitis B - Pipeline by Indian Immunologicals Ltd 96

Hepatitis B - Pipeline by Intellia Therapeutics Inc 97

Hepatitis B - Pipeline by Ionis Pharmaceuticals Inc 97

Hepatitis B - Pipeline by ISA Pharmaceuticals BV 98

Hepatitis B - Pipeline by Jiangsu Hansoh Pharmaceutical Group Co Ltd 98

Hepatitis B - Pipeline by Johnson & Johnson 99

Hepatitis B - Pipeline by Kineta Inc 99

Hepatitis B - Pipeline by Leukocare AG 100

Hepatitis B - Pipeline by LG Chem, Ltd. 100

Hepatitis B - Pipeline by Ligand Pharmaceuticals Inc 101

Hepatitis B - Pipeline by Medivir AB 101

Hepatitis B - Pipeline by Mucosis BV 102

Hepatitis B - Pipeline by MultiCell Technologies Inc 102

Hepatitis B - Pipeline by Oncolys BioPharma Inc 103

Hepatitis B - Pipeline by Panacea Biotec Ltd 103

Hepatitis B - Pipeline by Pfenex Inc 104

Hepatitis B - Pipeline by PharmaEssentia Corp 104

Hepatitis B - Pipeline by Profarma 105

Hepatitis B - Pipeline by Profectus BioSciences Inc 105

Hepatitis B - Pipeline by Replicor Inc 106

Hepatitis B - Pipeline by Rodos BioTarget GmbH 106

Hepatitis B - Pipeline by Samjin Pharmaceutical Co Ltd 107

Hepatitis B - Pipeline by Sanofi 107

Hepatitis B - Pipeline by Sanofi Pasteur SA 108

Hepatitis B - Pipeline by Scynexis Inc 108

Hepatitis B - Pipeline by Shantha Biotechnics Ltd 109

Hepatitis B - Pipeline by Sinovac Biotech Ltd 109

Hepatitis B - Pipeline by Spring Bank Pharmaceuticals Inc 110

Hepatitis B - Pipeline by TCM Biotech International Corp 110

Hepatitis B - Pipeline by Theravectys SA 111

Hepatitis B - Pipeline by THEVAX Genetics Vaccine USA Inc 111

Hepatitis B - Pipeline by Tomegavax Inc 112

Hepatitis B - Pipeline by Transgene SA 112

Hepatitis B - Pipeline by Vaxine Pty Ltd 113

Hepatitis B - Pipeline by VBI Vaccines Inc 113

Hepatitis B - Pipeline by Vical Inc 114

Hepatitis B - Pipeline by ViroStatics srl 114

patitis B - Pipeline by VLP Biotech Inc 115

Hepatitis B - Pipeline by Zydus Cadila Healthcare Ltd 115

Hepatitis C - Pipeline by 3-V Biosciences Inc 116

Hepatitis C - Pipeline by AbbVie Inc 116

Hepatitis C - Pipeline by AIMM Therapeutics BV 117

Hepatitis C - Pipeline by Akshaya Bio Inc 117

Hepatitis C - Pipeline by Amarillo Biosciences Inc 118

Hepatitis C - Pipeline by Amarna Therapeutics BV 118

Hepatitis C - Pipeline by ARA Healthcare Pvt Ltd 119

Hepatitis C - Pipeline by Aviragen Therapeutics Inc 119

Hepatitis C - Pipeline by Beijing Kawin Technology Share-Holding Co Ltd 120

Hepatitis C - Pipeline by Beta Pharma Inc 120

Hepatitis C - Pipeline by Biocad 121

Hepatitis C - Pipeline by Biotest Pharmaceuticals Corp 121

Hepatitis C - Pipeline by Biotron Ltd 122

Hepatitis C - Pipeline by Boehringer Ingelheim GmbH 122

Hepatitis C - Pipeline by Bolder Biotechnology Inc 123

Hepatitis C - Pipeline by Bristol-Myers Squibb Company 123

Hepatitis C - Pipeline by Cocrystal Pharma Inc 124

Hepatitis C - Pipeline by Conatus Pharmaceuticals Inc 124

Hepatitis C - Pipeline by ContraVir Pharmaceuticals Inc 125

Hepatitis C - Pipeline by DEKK-TEC Inc 125

Hepatitis C - Pipeline by Delpor Inc 126

Hepatitis C - Pipeline by F. Hoffmann-La Roche Ltd 126

Hepatitis C - Pipeline by Formune SL 127

Hepatitis C - Pipeline by Genecode AS 127

Hepatitis C - Pipeline by GeneCure LLC 128

Hepatitis C - Pipeline by Gilead Sciences Inc 128

Hepatitis C - Pipeline by GinkgoPharma Co Ltd 129

Hepatitis C - Pipeline by GlaxoSmithKline Plc 129

Hepatitis C - Pipeline by HanAll Biopharma Co Ltd 130

Hepatitis C - Pipeline by ImmunoBiology Ltd 130

Hepatitis C - Pipeline by ImmunoClin Corp 131

Hepatitis C - Pipeline by Immunotope Inc 131

Hepatitis C - Pipeline by Inovio Pharmaceuticals Inc 132

Hepatitis C - Pipeline by Integrated BioTherapeutics Inc 132

Hepatitis C - Pipeline by JN-International Medical Corp 133

Hepatitis C - Pipeline by Johnson & Johnson 133

Hepatitis C - Pipeline by Karyopharm Therapeutics Inc 134

Hepatitis C - Pipeline by Kineta Inc 134

Hepatitis C - Pipeline by Ligand Pharmaceuticals Inc 135

Hepatitis C - Pipeline by Medivir AB 135

Hepatitis C - Pipeline by Merck & Co Inc 136

Hepatitis C - Pipeline by Microbio Co Ltd 137

Hepatitis C - Pipeline by Microbiotix Inc 137

Hepatitis C - Pipeline by MultiCell Technologies Inc 138

Hepatitis C - Pipeline by NeuroVive Pharmaceutical AB 138

Hepatitis C - Pipeline by Novalex Therapeutics Inc 139

Hepatitis C - Pipeline by Novartis AG 139

Hepatitis C - Pipeline by NovaTarg Therapeutics Inc 140

Hepatitis C - Pipeline by Ono Pharmaceutical Co Ltd 140

Hepatitis C - Pipeline by Pfenex Inc 141

Hepatitis C - Pipeline by Pfizer Inc 141

Hepatitis C - Pipeline by PharmaEssentia Corp 142

Hepatitis C - Pipeline by Presidio Pharmaceuticals Inc 142

Hepatitis C - Pipeline by Profectus BioSciences Inc 143

Hepatitis C - Pipeline by Replicor Inc 143

Hepatitis C - Pipeline by Rodos BioTarget GmbH 144

Hepatitis C - Pipeline by Solon Eiendom ASA 144

Hepatitis C - Pipeline by SomaGenics Inc 145

Hepatitis C - Pipeline by Sorrento Therapeutics Inc 145

Hepatitis C - Pipeline by Sudershan Biotech Ltd 146

Hepatitis C - Pipeline by TaiGen Biotechnology Co Ltd 146

Hepatitis C - Pipeline by TaiwanJ Pharmaceuticals Co Ltd 147

Hepatitis C - Pipeline by Therapure Biopharma Inc 147

Hepatitis C - Pipeline by Theravectys SA 148

Hepatitis C - Pipeline by THEVAX Genetics Vaccine USA Inc 148

Hepatitis C - Pipeline by Vakzine Projekt Management GmbH 149

Hepatitis C - Pipeline by Vertex Pharmaceuticals Inc 149

Hepatitis C - Pipeline by WhanIn Pharmaceutical Co Ltd 150

Hepatitis C - Pipeline by Zylacta Corp 150

Hepatitis D - Pipeline by Alnylam Pharmaceuticals Inc 151

Hepatitis D - Pipeline by Eiger BioPharmaceuticals Inc 151

Hepatitis D - Pipeline by F. Hoffmann-La Roche Ltd 152

Hepatitis D - Pipeline by Globeimmune Inc 152

Hepatitis D - Pipeline by Replicor Inc 153

Hepatitis D - Pipeline by Rodos BioTarget GmbH 153

Hepatitis D - Pipeline by SomaGenics Inc 154

Hepatitis D - Pipeline by Spring Bank Pharmaceuticals Inc 154

Hepatitis A - Dormant Projects 155

Hepatitis B - Dormant Projects 155

Hepatitis C - Dormant Projects 159

Hepatitis D - Dormant Projects 169

Hepatitis B - Discontinued Products 170

Hepatitis C - Discontinued Products 170

Hepatitis D - Discontinued Products 173

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