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Herpes Zoster (Shingles)-Pipeline Review, H1 2015

Herpes Zoster (Shingles)-Pipeline Review, H1 2015


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Executive Summary

Herpes Zoster (Shingles)-Pipeline Review, H1 2015

Summary

Global Markets Direct's, 'Herpes Zoster (Shingles)-Pipeline Review, H1 2015', provides an overview of the Herpes Zoster (Shingles)'s therapeutic pipeline.

This report provides comprehensive information on the therapeutic development for Herpes Zoster (Shingles), complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Herpes Zoster (Shingles) and special features on late-stage and discontinued projects.

Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis.

The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.

Scope

The report provides a snapshot of the global therapeutic landscape of Herpes Zoster (Shingles)

The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities

The report reviews key players involved in the therapeutics development for Herpes Zoster (Shingles) and enlists all their major and minor projects

The report summarizes all the dormant and discontinued pipeline projects

A review of the Herpes Zoster (Shingles) products under development by companies and universities/research institutes based on information derived from company and industry-specific sources

Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages

A detailed assessment of monotherapy and combination therapy pipeline projects

Coverage of the Herpes Zoster (Shingles) pipeline on the basis of target, MoA, route of administration and molecule type

Latest news and deals relating related to pipeline products

Reasons To Buy

Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies

Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage

Develop strategic initiatives by understanding the focus areas of leading companies

Identify and understand important and diverse types of therapeutics under development for Herpes Zoster (Shingles)

Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline

Devise corrective measures for pipeline projects by understanding Herpes Zoster (Shingles) pipeline depth and focus of Indication therapeutics

Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline

Table of Contents

Table of Contents 2

List of Tables 4

List of Figures 5

Introduction 6

Global Markets Direct Report Coverage 6

Herpes Zoster (Shingles) Overview 7

Therapeutics Development 8

Pipeline Products for Herpes Zoster (Shingles)-Overview 8

Pipeline Products for Herpes Zoster (Shingles)-Comparative Analysis 9

Herpes Zoster (Shingles)-Therapeutics under Development by Companies 10

Herpes Zoster (Shingles)-Pipeline Products Glance 11

Late Stage Products 11

Clinical Stage Products 12

Early Stage Products 13

Unknown Stage Products 14

Herpes Zoster (Shingles)-Products under Development by Companies 15

Herpes Zoster (Shingles)-Companies Involved in Therapeutics Development 16

Astellas Pharma Inc. 16

Epiphany Biosciences, Inc. 17

Foamix Pharmaceuticals Ltd. 18

GlaxoSmithKline plc 19

Merck & Co., Inc. 20

NAL Pharmaceuticals Ltd. 21

Spider Biotech 22

Herpes Zoster (Shingles)-Therapeutics Assessment 23

Assessment by Monotherapy Products 23

Assessment by Target 24

Assessment by Mechanism of Action 26

Assessment by Route of Administration 28

Assessment by Molecule Type 30

Drug Profiles 32

acyclovir-Drug Profile 32

Product Description 32

Mechanism of Action 32

R&D Progress 32

amenamevir-Drug Profile 33

Product Description 33

Mechanism of Action 33

R&D Progress 33

FV-100-Drug Profile 34

Product Description 34

Mechanism of Action 34

R&D Progress 34

GSK-1437173A-Drug Profile 36

Product Description 36

Mechanism of Action 36

R&D Progress 36

NAL-3221-Drug Profile 38

Product Description 38

Mechanism of Action 38

R&D Progress 38

NAL-3223-Drug Profile 39

Product Description 39

Mechanism of Action 39

R&D Progress 39

SB105-A10-Drug Profile 40

Product Description 40

Mechanism of Action 40

R&D Progress 40

V-212-Drug Profile 42

Product Description 42

Mechanism of Action 42

R&D Progress 42

valomaciclovir stearate-Drug Profile 44

Product Description 44

Mechanism of Action 44

R&D Progress 44

Herpes Zoster (Shingles)-Recent Pipeline Updates 46

Herpes Zoster (Shingles)-Dormant Projects 50

Herpes Zoster (Shingles)-Discontinued Products 51

Herpes Zoster (Shingles)-Product Development Milestones 52

Featured News & Press Releases 52

Mar 09, 2015: ContraVir Pharmaceuticals to Initiate Pivotal Phase 3 Study of FV-100 for Prevention of Shingles-Associated PHN 52

Dec 18, 2014: Pivotal phase III study of GSK shingles candidate vaccine meets its primary endpoint 52

Dec 18, 2014: Positive Outcome of Phase 3 Study of GSK Shingles Vaccine Containing Agenus Adjuvant 53

Dec 09, 2014: ContraVir Pharmaceuticals Initiates Pharmacokinetic Study of Lead Antiviral FV-100 for Treating Shingles 53

Oct 16, 2014: ContraVir Pharmaceuticals Selects Pharmaceutical Product Development to Manage Phase 2b Study of Lead Antiviral FV-100 for Treating Shingles 54

Apr 09, 2013: Zoster Vaccine Effective Against Incident Herpes Zoster And Post-herpetic Neuralgia In Older US Population, Cohort Study Finds 54

Jul 18, 2012: Agenus Annnounces Intiation Of Phase III Clinical Trial Of GSK's Herpes Zoster Vaccine Candidate In Immunocompromised Patients 56

Jun 05, 2012: Kaiser Permanente Study Shows GSK's Zoster Lowers Short-Term Risk Of Shingles Recurrence 57

Dec 13, 2010: Inhibitex Reports Promising Top-Line Results From Phase II Shingles Trial With FV-100 58

Oct 15, 2010: Inhibitex Completes Enrollment In Phase II Clinical Trial Of FV-100 In Shingles Patients 59

Appendix 60

Methodology 60

Coverage 60

Secondary Research 60

Primary Research 60

Expert Panel Validation 60

Contact Us 60

Disclaimer 61

List of Tables

Number of Products under Development for Herpes Zoster (Shingles), H1 2015 8

Number of Products under Development for Herpes Zoster (Shingles)-Comparative Analysis, H1 2015 9

Number of Products under Development by Companies, H1 2015 10

Comparative Analysis by Late Stage Development, H1 2015 11

Comparative Analysis by Clinical Stage Development, H1 2015 12

Comparative Analysis by Early Stage Development, H1 2015 13

Comparative Analysis by Unknown Stage Development, H1 2015 14

Products under Development by Companies, H1 2015 15

Herpes Zoster (Shingles)-Pipeline by Astellas Pharma Inc., H1 2015 16

Herpes Zoster (Shingles)-Pipeline by Epiphany Biosciences, Inc., H1 2015 17

Herpes Zoster (Shingles)-Pipeline by Foamix Pharmaceuticals Ltd., H1 2015 18

Herpes Zoster (Shingles)-Pipeline by GlaxoSmithKline plc, H1 2015 19

Herpes Zoster (Shingles)-Pipeline by Merck & Co., Inc., H1 2015 20

Herpes Zoster (Shingles)-Pipeline by NAL Pharmaceuticals Ltd., H1 2015 21

Herpes Zoster (Shingles)-Pipeline by Spider Biotech, H1 2015 22

Assessment by Monotherapy Products, H1 2015 23

Number of Products by Stage and Target, H1 2015 25

Number of Products by Stage and Mechanism of Action, H1 2015 27

Number of Products by Stage and Route of Administration, H1 2015 29

Number of Products by Stage and Molecule Type, H1 2015 31

Herpes Zoster (Shingles) Therapeutics-Recent Pipeline Updates, H1 2015 46

Herpes Zoster (Shingles)-Dormant Projects, H1 2015 50

Herpes Zoster (Shingles)-Discontinued Products, H1 2015 51

List of Figures

Number of Products under Development for Herpes Zoster (Shingles), H1 2015 8

Number of Products under Development for Herpes Zoster (Shingles)-Comparative Analysis, H1 2015 9

Number of Products under Development by Companies, H1 2015 10

Comparative Analysis by Early Stage Products, H1 2015 13

Assessment by Monotherapy Products, H1 2015 23

Number of Products by Top 10 Targets, H1 2015 24

Number of Products by Stage and Top 10 Targets, H1 2015 25

Number of Products by Top 10 Mechanism of Actions, H1 2015 26

Number of Products by Stage and Top 10 Mechanism of Actions, H1 2015 27

Number of Products by Top 10 Routes of Administration, H1 2015 28

Number of Products by Stage and Top 10 Routes of Administration, H1 2015 29

Number of Products by Top 10 Molecule Types, H1 2015 30

Number of Products by Stage and Top 10 Molecule Types, H1 2015 31

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Astellas Pharma Inc.

Epiphany Biosciences, Inc.

Foamix Pharmaceuticals Ltd.

GlaxoSmithKline plc

Merck & Co., Inc.

NAL Pharmaceuticals Ltd.

Spider Biotech

Herpes Zoster (Shingles) Therapeutic Products under Development, Key Players in Herpes Zoster (Shingles) Therapeutics, Herpes Zoster (Shingles) Pipeline Overview, Herpes Zoster (Shingles) Pipeline, Herpes Zoster (Shingles) Pipeline Assessment


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