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Hyperphosphatemia-Pipeline Review, H2 2015

Hyperphosphatemia-Pipeline Review, H2 2015

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Executive Summary

Hyperphosphatemia-Pipeline Review, H2 2015


Global Markets Direct's, 'Hyperphosphatemia-Pipeline Review, H2 2015', provides an overview of the Hyperphosphatemia's therapeutic pipeline.

This report provides comprehensive information on the therapeutic development for Hyperphosphatemia, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Hyperphosphatemia and special features on late-stage and discontinued projects.

Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis.

The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.


The report provides a snapshot of the global therapeutic landscape of Hyperphosphatemia

The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities

The report reviews key players involved in the therapeutics development for Hyperphosphatemia and enlists all their major and minor projects

The report summarizes all the dormant and discontinued pipeline projects

A review of the Hyperphosphatemia products under development by companies and universities/research institutes based on information derived from company and industry-specific sources

Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages

A detailed assessment of monotherapy and combination therapy pipeline projects

Coverage of the Hyperphosphatemia pipeline on the basis of target, MoA, route of administration and molecule type

Latest news and deals relating related to pipeline products

Reasons To Buy

Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies

Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage

Develop strategic initiatives by understanding the focus areas of leading companies

Identify and understand important and diverse types of therapeutics under development for Hyperphosphatemia

Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline

Devise corrective measures for pipeline projects by understanding Hyperphosphatemia pipeline depth and focus of Indication therapeutics

Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline

Table of Contents

Table of Contents 2

List of Tables 6

List of Figures 6

Introduction 7

Global Markets Direct Report Coverage 7

Hyperphosphatemia Overview 8

Therapeutics Development 9

Pipeline Products for Hyperphosphatemia-Overview 9

Pipeline Products for Hyperphosphatemia-Comparative Analysis 10

Hyperphosphatemia-Therapeutics under Development by Companies 11

Hyperphosphatemia-Therapeutics under Investigation by Universities/Institutes 12

Hyperphosphatemia-Pipeline Products Glance 13

Late Stage Products 13

Clinical Stage Products 14

Early Stage Products 15

Hyperphosphatemia-Products under Development by Companies 16

Hyperphosphatemia-Products under Investigation by Universities/Institutes 17

Hyperphosphatemia-Companies Involved in Therapeutics Development 18

3SBio Inc. 18

Ardelyx, Inc. 19

Galenica Ltd. 20

Medice Arzneimittel Putter GmbH & Co. KG 21

OPKO Health, Inc. 22

Panion & Bf Biotech Inc 23

Sanofi 24

Spectrum Pharmaceuticals, Inc. 25

Toray Industries, Inc. 26

Hyperphosphatemia-Therapeutics Assessment 27

Assessment by Monotherapy Products 27

Assessment by Target 28

Assessment by Mechanism of Action 30

Assessment by Route of Administration 32

Assessment by Molecule Type 33

Drug Profiles 35

colestilan chloride-Drug Profile 35

Product Description 35

Mechanism of Action 35

R&D Progress 35

CPAM-11-Drug Profile 36

Product Description 36

Mechanism of Action 36

R&D Progress 36

fermagate-Drug Profile 37

Product Description 37

Mechanism of Action 37

R&D Progress 37

ferric citrate-Drug Profile 38

Product Description 38

Mechanism of Action 38

R&D Progress 38

calcium succinate-Drug Profile 41

Product Description 41

Mechanism of Action 41

R&D Progress 41

JPH-101-Drug Profile 42

Product Description 42

Mechanism of Action 42

R&D Progress 42

niacinamide-Drug Profile 43

Product Description 43

Mechanism of Action 43

R&D Progress 43

PDX-003-Drug Profile 44

Product Description 44

Mechanism of Action 44

R&D Progress 44

PT-20-Drug Profile 46

Product Description 46

Mechanism of Action 46

R&D Progress 46

RDX-002-Drug Profile 47

Product Description 47

Mechanism of Action 47

R&D Progress 47

sevelamer carbonate-Drug Profile 48

Product Description 48

Mechanism of Action 48

R&D Progress 48

Small Molecule to Target Phosphate for Hyperphosphatemia-Drug Profile 49

Product Description 49

Mechanism of Action 49

R&D Progress 49

Small Molecules to Inhibit Phosphate Transport for Hyperphosphatemia In CKD-Drug Profile 50

Product Description 50

Mechanism of Action 50

R&D Progress 50

SPI-014-Drug Profile 51

Product Description 51

Mechanism of Action 51

R&D Progress 51

succharated ferric oxide-Drug Profile 52

Product Description 52

Mechanism of Action 52

R&D Progress 52

tenapanor hydrochloride-Drug Profile 54

Product Description 54

Mechanism of Action 54

R&D Progress 54

TRK-390-Drug Profile 56

Product Description 56

Mechanism of Action 56

R&D Progress 56

VS-501-Drug Profile 57

Product Description 57

Mechanism of Action 57

R&D Progress 57

VS-505-Drug Profile 58

Product Description 58

Mechanism of Action 58

R&D Progress 58

Hyperphosphatemia-Recent Pipeline Updates 59

Hyperphosphatemia-Dormant Projects 71

Hyperphosphatemia-Discontinued Products 72

Hyperphosphatemia-Product Development Milestones 73

Featured News & Press Releases 73

Mar 04, 2015: Keryx Biopharmaceuticals Announces Publication of Auryxia (ferric citrate) Analysis in Journal of the American Society of Nephrology 73

Feb 02, 2015: Ardelyx Reports Results from Phase 2b Clinical Trial Evaluating Tenapanor in Treating Hyperphosphatemia in Chronic Kidney Disease Patients on Hemodialysis 73

Jan 27, 2015: Velphoro receives Swissmedic approval for the treatment of hyperphosphatemia in adult patients with chronic kidney disease on dialysis 74

Jan 09, 2015: Keryx Biopharmaceuticals Turns to Veeva Commercial Cloud to Support First FDA-Approved Product Launch 74

Dec 04, 2014: Keryx Biopharmaceuticals Announces Issuance of a New U.S. Patent for Auryxia (ferric citrate) Covering Orally Administrable Forms 75

Nov 19, 2014: New Drug Application Submitted For PA21 (development code) For Treatment Of Hyperphosphatemia 76

Nov 17, 2014: Keryx Biopharmaceuticals Announces Trade Name Auryxia for Ferric Citrate 76

Nov 15, 2014: Keryx Biopharmaceuticals Announces Results From Ferric Citrate Phase 3 Long-Term Safety Extension Study 77

Oct 23, 2014: Ardelyx's Tenapanor Selected for Oral and Poster Presentations at the American Society of Nephrology's Kidney Week 2014 78

Oct 01, 2014: Keryx Biopharmaceuticals Announces Issuance of a New U.S. Patent for Ferric Citrate Covering Orally Administrable Forms 79

Appendix 81

Methodology 81

Coverage 81

Secondary Research 81

Primary Research 81

Expert Panel Validation 81

Contact Us 81

Disclaimer 82

List of Tables

Number of Products under Development for Hyperphosphatemia, H2 2015 9

Number of Products under Development for Hyperphosphatemia-Comparative Analysis, H2 2015 10

Number of Products under Development by Companies, H2 2015 11

Number of Products under Investigation by Universities/Institutes, H2 2015 12

Comparative Analysis by Late Stage Development, H2 2015 13

Comparative Analysis by Clinical Stage Development, H2 2015 14

Comparative Analysis by Early Stage Development, H2 2015 15

Products under Development by Companies, H2 2015 16

Products under Investigation by Universities/Institutes, H2 2015 17

Hyperphosphatemia-Pipeline by 3SBio Inc., H2 2015 18

Hyperphosphatemia-Pipeline by Ardelyx, Inc., H2 2015 19

Hyperphosphatemia-Pipeline by Galenica Ltd., H2 2015 20

Hyperphosphatemia-Pipeline by Medice Arzneimittel Putter GmbH & Co. KG, H2 2015 21

Hyperphosphatemia-Pipeline by OPKO Health, Inc., H2 2015 22

Hyperphosphatemia-Pipeline by Panion & Bf Biotech Inc, H2 2015 23

Hyperphosphatemia-Pipeline by Sanofi, H2 2015 24

Hyperphosphatemia-Pipeline by Spectrum Pharmaceuticals, Inc., H2 2015 25

Hyperphosphatemia-Pipeline by Toray Industries, Inc., H2 2015 26

Assessment by Monotherapy Products, H2 2015 27

Number of Products by Stage and Target, H2 2015 29

Number of Products by Stage and Mechanism of Action, H2 2015 31

Number of Products by Stage and Route of Administration, H2 2015 32

Number of Products by Stage and Molecule Type, H2 2015 34

Hyperphosphatemia Therapeutics-Recent Pipeline Updates, H2 2015 59

Hyperphosphatemia-Dormant Projects, H2 2015 71

Hyperphosphatemia-Discontinued Products, H2 2015 72

List of Figures

Number of Products under Development for Hyperphosphatemia, H2 2015 9

Number of Products under Development for Hyperphosphatemia-Comparative Analysis, H2 2015 10

Number of Products under Development by Companies, H2 2015 11

Comparative Analysis by Late Stage Development, H2 2015 13

Comparative Analysis by Early Stage Products, H2 2015 15

Assessment by Monotherapy Products, H2 2015 27

Number of Products by Top 10 Targets, H2 2015 28

Number of Products by Stage and Top 10 Targets, H2 2015 28

Number of Products by Top 10 Mechanism of Actions, H2 2015 30

Number of Products by Stage and Top 10 Mechanism of Actions, H2 2015 30

Number of Products by Stage and Top 10 Routes of Administration, H2 2015 32

Number of Products by Top 10 Molecule Types, H2 2015 33

Number of Products by Stage and Top 10 Molecule Types, H2 2015 33

Single User License:
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3SBio Inc.

Ardelyx, Inc.

Galenica Ltd.

Medice Arzneimittel Putter GmbH & Co. KG

OPKO Health, Inc.

Panion & Bf Biotech Inc


Spectrum Pharmaceuticals, Inc.

Toray Industries, Inc.

Hyperphosphatemia Therapeutic Products under Development, Key Players in Hyperphosphatemia Therapeutics, Hyperphosphatemia Pipeline Overview, Hyperphosphatemia Pipeline, Hyperphosphatemia Pipeline Assessment

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