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Hypoglycemia-Pipeline Review, H1 2015

Hypoglycemia-Pipeline Review, H1 2015


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Executive Summary

Hypoglycemia-Pipeline Review, H1 2015

Summary

Global Markets Direct's, 'Hypoglycemia-Pipeline Review, H1 2015', provides an overview of the Hypoglycemia's therapeutic pipeline.

This report provides comprehensive information on the therapeutic development for Hypoglycemia, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Hypoglycemia and special features on late-stage and discontinued projects.

Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis.

The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.

Scope

The report provides a snapshot of the global therapeutic landscape of Hypoglycemia

The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities

The report reviews key players involved in the therapeutics development for Hypoglycemia and enlists all their major and minor projects

The report summarizes all the dormant and discontinued pipeline projects

A review of the Hypoglycemia products under development by companies and universities/research institutes based on information derived from company and industry-specific sources

Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages

A detailed assessment of monotherapy and combination therapy pipeline projects

Coverage of the Hypoglycemia pipeline on the basis of target, MoA, route of administration and molecule type

Latest news and deals relating related to pipeline products

Reasons To Buy

Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies

Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage

Develop strategic initiatives by understanding the focus areas of leading companies

Identify and understand important and diverse types of therapeutics under development for Hypoglycemia

Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline

Devise corrective measures for pipeline projects by understanding Hypoglycemia pipeline depth and focus of Indication therapeutics

Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline

Table of Contents

Table of Contents 2

List of Tables 4

List of Figures 4

Introduction 5

Global Markets Direct Report Coverage 5

Hypoglycemia Overview 6

Therapeutics Development 7

Pipeline Products for Hypoglycemia-Overview 7

Pipeline Products for Hypoglycemia-Comparative Analysis 8

Hypoglycemia-Therapeutics under Development by Companies 9

Hypoglycemia-Therapeutics under Investigation by Universities/Institutes 10

Hypoglycemia-Pipeline Products Glance 11

Clinical Stage Products 11

Early Stage Products 12

Hypoglycemia-Products under Development by Companies 13

Hypoglycemia-Products under Investigation by Universities/Institutes 14

Hypoglycemia-Companies Involved in Therapeutics Development 15

Biodel Inc. 15

USV Limited 16

XERIS Pharmaceuticals, Inc. 17

XOMA Corporation 18

Zealand Pharma A/S 19

Hypoglycemia-Therapeutics Assessment 20

Assessment by Monotherapy Products 20

Assessment by Target 21

Assessment by Mechanism of Action 23

Assessment by Route of Administration 25

Assessment by Molecule Type 27

Drug Profiles 29

glucagon-Drug Profile 29

Product Description 29

Mechanism of Action 29

R&D Progress 29

glucagon-Drug Profile 30

Product Description 30

Mechanism of Action 30

R&D Progress 30

glucagon-Drug Profile 32

Product Description 32

Mechanism of Action 32

R&D Progress 32

glucagon biosimilar-Drug Profile 33

Product Description 33

Mechanism of Action 33

R&D Progress 33

Peptide for Cardiovascular and Hypoglycemia-Drug Profile 34

Product Description 34

Mechanism of Action 34

R&D Progress 34

XOMA-358-Drug Profile 35

Product Description 35

Mechanism of Action 35

R&D Progress 35

ZP-4207-Drug Profile 36

Product Description 36

Mechanism of Action 36

R&D Progress 36

Hypoglycemia-Recent Pipeline Updates 37

Hypoglycemia-Dormant Projects 40

Hypoglycemia-Product Development Milestones 41

Featured News & Press Releases 41

Dec 04, 2014: Biodel Initiates Clinical Proof of Concept Study in Glucagon Emergency Management Program 41

Nov 17, 2014: Zealand advances its proprietary stable glucagon analogue for severe hypoglycemia in diabetes into clinical development 41

Nov 12, 2014: FDA and EMA Grant Orphan Designation to Xeris Pharmaceuticals' Soluble Glucagon for Prevention of Hypoglycemia in Congenital Hyperinsulinism Patients 42

Jun 17, 2014: Zealand presented new data on ZP-GA-1 novel peptide therapeutics from its preclinical diabetes pipeline at the American Diabetes Association's (ADA) 74th Scientific Sessions 43

Apr 24, 2014: Xeris Pharmaceuticals Announces Dosing of First Patient in Phase 2 Clinical Trial of its Investigational Soluble Glucagon Formulation for Pumps 44

Oct 17, 2013: Xeris Pharmaceuticals Announces Dosing of First Patient in Phase 2 Clinical Trial of its Investigational Soluble Glucagon Formulation 45

Jul 03, 2013: Biodel to Present New Preclinical Glucagon Data During Corporate Overview at JMP Securities Healthcare Conference 45

Jun 22, 2013: Zealand Pharma Presents Preclinical Data On Hypoglycemic Drug ZP-GA-1 At 73rd ADA Scientific Sessions 45

Jun 06, 2013: Biodel Plans To Submit New Drug Application For Glucagon Rescue Product Candidate To Treat Severe Hypoglycemia 46

Dec 06, 2012: Biodel's Glucagon Obtains FDA Orphan Drug Designation To Prevent Hypoglycemia In Congenital Hyperinsulinism Population 47

Appendix 48

Methodology 48

Coverage 48

Secondary Research 48

Primary Research 48

Expert Panel Validation 48

Contact Us 48

Disclaimer 49

List of Tables

Number of Products under Development for Hypoglycemia, H1 2015 7

Number of Products under Development for Hypoglycemia-Comparative Analysis, H1 2015 8

Number of Products under Development by Companies, H1 2015 9

Number of Products under Investigation by Universities/Institutes, H1 2015 10

Comparative Analysis by Clinical Stage Development, H1 2015 11

Comparative Analysis by Early Stage Development, H1 2015 12

Products under Development by Companies, H1 2015 13

Products under Investigation by Universities/Institutes, H1 2015 14

Hypoglycemia-Pipeline by Biodel Inc., H1 2015 15

Hypoglycemia-Pipeline by USV Limited, H1 2015 16

Hypoglycemia-Pipeline by XERIS Pharmaceuticals, Inc., H1 2015 17

Hypoglycemia-Pipeline by XOMA Corporation, H1 2015 18

Hypoglycemia-Pipeline by Zealand Pharma A/S, H1 2015 19

Assessment by Monotherapy Products, H1 2015 20

Number of Products by Stage and Target, H1 2015 22

Number of Products by Stage and Mechanism of Action, H1 2015 24

Number of Products by Stage and Route of Administration, H1 2015 26

Number of Products by Stage and Molecule Type, H1 2015 28

Hypoglycemia Therapeutics-Recent Pipeline Updates, H1 2015 37

Hypoglycemia-Dormant Projects, H1 2015 40

List of Figures

Number of Products under Development for Hypoglycemia, H1 2015 7

Number of Products under Development for Hypoglycemia-Comparative Analysis, H1 2015 8

Number of Products under Development by Companies, H1 2015 9

Comparative Analysis by Clinical Stage Development, H1 2015 11

Assessment by Monotherapy Products, H1 2015 20

Number of Products by Top 10 Targets, H1 2015 21

Number of Products by Stage and Top 10 Targets, H1 2015 22

Number of Products by Top 10 Mechanism of Actions, H1 2015 23

Number of Products by Stage and Top 10 Mechanism of Actions, H1 2015 24

Number of Products by Top 10 Routes of Administration, H1 2015 25

Number of Products by Stage and Top 10 Routes of Administration, H1 2015 26

Number of Products by Top 10 Molecule Types, H1 2015 27

Number of Products by Stage and Top 10 Molecule Types, H1 2015 28

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Biodel Inc.

USV Limited

XERIS Pharmaceuticals, Inc.

XOMA Corporation

Zealand Pharma A/S

Hypoglycemia Therapeutic Products under Development, Key Players in Hypoglycemia Therapeutics, Hypoglycemia Pipeline Overview, Hypoglycemia Pipeline, Hypoglycemia Pipeline Assessment


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