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Interstitial Cystitis (Painful Bladder Syndrome)-Pipeline Review, H1 2015

Interstitial Cystitis (Painful Bladder Syndrome)-Pipeline Review, H1 2015


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Executive Summary

Interstitial Cystitis (Painful Bladder Syndrome)-Pipeline Review, H1 2015

Summary

Global Markets Direct's, 'Interstitial Cystitis (Painful Bladder Syndrome)-Pipeline Review, H1 2015', provides an overview of the Interstitial Cystitis (Painful Bladder Syndrome)'s therapeutic pipeline.

This report provides comprehensive information on the therapeutic development for Interstitial Cystitis (Painful Bladder Syndrome), complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Interstitial Cystitis (Painful Bladder Syndrome) and special features on late-stage and discontinued projects.

Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis.

The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.

Scope

The report provides a snapshot of the global therapeutic landscape of Interstitial Cystitis (Painful Bladder Syndrome)

The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities

The report reviews key players involved in the therapeutics development for Interstitial Cystitis (Painful Bladder Syndrome) and enlists all their major and minor projects

The report summarizes all the dormant and discontinued pipeline projects

A review of the Interstitial Cystitis (Painful Bladder Syndrome) products under development by companies and universities/research institutes based on information derived from company and industry-specific sources

Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages

A detailed assessment of monotherapy and combination therapy pipeline projects

Coverage of the Interstitial Cystitis (Painful Bladder Syndrome) pipeline on the basis of target, MoA, route of administration and molecule type

Latest news and deals relating related to pipeline products

Reasons To Buy

Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies

Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage

Develop strategic initiatives by understanding the focus areas of leading companies

Identify and understand important and diverse types of therapeutics under development for Interstitial Cystitis (Painful Bladder Syndrome)

Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline

Devise corrective measures for pipeline projects by understanding Interstitial Cystitis (Painful Bladder Syndrome) pipeline depth and focus of Indication therapeutics

Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline

Table of Contents

Table of Contents 2

List of Tables 5

List of Figures 5

Introduction 6

Global Markets Direct Report Coverage 6

Interstitial Cystitis (Painful Bladder Syndrome) Overview 7

Therapeutics Development 8

Pipeline Products for Interstitial Cystitis (Painful Bladder Syndrome)-Overview 8

Pipeline Products for Interstitial Cystitis (Painful Bladder Syndrome)-Comparative Analysis 9

Interstitial Cystitis (Painful Bladder Syndrome)-Therapeutics under Development by Companies 10

Interstitial Cystitis (Painful Bladder Syndrome)-Therapeutics under Investigation by Universities/Institutes 11

Interstitial Cystitis (Painful Bladder Syndrome)-Pipeline Products Glance 12

Clinical Stage Products 12

Early Stage Products 13

Interstitial Cystitis (Painful Bladder Syndrome)-Products under Development by Companies 14

Interstitial Cystitis (Painful Bladder Syndrome)-Products under Investigation by Universities/Institutes 15

Interstitial Cystitis (Painful Bladder Syndrome)-Companies Involved in Therapeutics Development 16

Afferent Pharmaceuticals, Inc. 16

Allergan, Inc. 17

Aquinox Pharmaceuticals Inc. 18

Kytogenics Pharmaceuticals, Inc. 19

Lipella Pharmaceuticals, Inc. 20

Qu Biologics Inc. 21

Urigen Pharmaceuticals, Inc. 22

Interstitial Cystitis (Painful Bladder Syndrome)-Therapeutics Assessment 23

Assessment by Monotherapy Products 23

Assessment by Combination Products 24

Assessment by Target 25

Assessment by Mechanism of Action 27

Assessment by Route of Administration 29

Assessment by Molecule Type 31

Drug Profiles 33

(lidocaine + heparin)-Drug Profile 33

Product Description 33

Mechanism of Action 33

R&D Progress 33

AF-219-Drug Profile 35

Product Description 35

Mechanism of Action 35

R&D Progress 35

AQX-1125-Drug Profile 37

Product Description 37

Mechanism of Action 37

R&D Progress 37

GM-0111-Drug Profile 39

Product Description 39

Mechanism of Action 39

R&D Progress 39

GM-1111-Drug Profile 41

Product Description 41

Mechanism of Action 41

R&D Progress 41

lidocaine-Drug Profile 43

Product Description 43

Mechanism of Action 43

R&D Progress 43

LP-08-Drug Profile 45

Product Description 45

Mechanism of Action 45

R&D Progress 45

mesalamine-Drug Profile 47

Product Description 47

Mechanism of Action 47

R&D Progress 47

NEO-5024-Drug Profile 48

Product Description 48

Mechanism of Action 48

R&D Progress 48

NEO-5937-Drug Profile 49

Product Description 49

Mechanism of Action 49

R&D Progress 49

onabotulinumtoxin A liposomal-Drug Profile 50

Product Description 50

Mechanism of Action 50

R&D Progress 50

QBECP-SSI-Drug Profile 52

Product Description 52

Mechanism of Action 52

R&D Progress 52

Interstitial Cystitis (Painful Bladder Syndrome)-Recent Pipeline Updates 53

Interstitial Cystitis (Painful Bladder Syndrome)-Dormant Projects 58

Interstitial Cystitis (Painful Bladder Syndrome)-Discontinued Products 59

Interstitial Cystitis (Painful Bladder Syndrome)-Product Development Milestones 60

Featured News & Press Releases 60

Mar 02, 2015: Aquinox Pharmaceuticals Completes Enrollment in the Phase 2 LEADERSHIP Trial of AQX-1125 in Bladder Pain Syndrome/Interstitial Cystitis 60

Feb 26, 2015: Afferent Clinical Data for Lead Candidate, AF-219, Demonstrate Improvements in Pain and Urinary Urgency in Interstitial Cystitis / Bladder Pain Syndrome 60

Jun 02, 2014: Aquinox Pharmaceuticals Announces Expansion of Ongoing Phase 2 Trials of AQX-1125, Including Acceptance of U.S. IND 61

Sep 09, 2013: Afferent Pharmaceuticals Reports Positive Phase 2 Clinical Data for the Company's Lead P2X3 Antagonist, AF-219 62

Jul 23, 2013: Aquinox Pharmaceuticals commences Phase II clinical trial of AQX-1125 in Bladder Pain Syndrome/Interstitial Cystitis 63

Apr 02, 2013: Taris Doses First Patient In Second Phase II Clinical Study Of LiRIS For Treatment Of Interstitial Cystitis 63

Nov 30, 2011: TARIS Initiates Phase II Clinical Study With LiRIS In Interstitial Cystitis Patients 64

Jun 30, 2011: Urigen Provides Development Update For URG101 64

Mar 09, 2011: TARIS Initiates Clinical Study In Interstitial Cystitis Patients 64

Aug 18, 2010: Urigen Reports Type C Meeting With FDA For URG101 65

Appendix 66

Methodology 66

Coverage 66

Secondary Research 66

Primary Research 66

Expert Panel Validation 66

Contact Us 66

Disclaimer 67

List of Tables

Number of Products under Development for Interstitial Cystitis (Painful Bladder Syndrome), H1 2015 8

Number of Products under Development for Interstitial Cystitis (Painful Bladder Syndrome)-Comparative Analysis, H1 2015 9

Number of Products under Development by Companies, H1 2015 10

Number of Products under Investigation by Universities/Institutes, H1 2015 11

Comparative Analysis by Clinical Stage Development, H1 2015 12

Comparative Analysis by Early Stage Development, H1 2015 13

Products under Development by Companies, H1 2015 14

Products under Investigation by Universities/Institutes, H1 2015 15

Interstitial Cystitis (Painful Bladder Syndrome)-Pipeline by Afferent Pharmaceuticals, Inc., H1 2015 16

Interstitial Cystitis (Painful Bladder Syndrome)-Pipeline by Allergan, Inc., H1 2015 17

Interstitial Cystitis (Painful Bladder Syndrome)-Pipeline by Aquinox Pharmaceuticals Inc., H1 2015 18

Interstitial Cystitis (Painful Bladder Syndrome)-Pipeline by Kytogenics Pharmaceuticals, Inc., H1 2015 19

Interstitial Cystitis (Painful Bladder Syndrome)-Pipeline by Lipella Pharmaceuticals, Inc., H1 2015 20

Interstitial Cystitis (Painful Bladder Syndrome)-Pipeline by Qu Biologics Inc., H1 2015 21

Interstitial Cystitis (Painful Bladder Syndrome)-Pipeline by Urigen Pharmaceuticals, Inc., H1 2015 22

Assessment by Monotherapy Products, H1 2015 23

Assessment by Combination Products, H1 2015 24

Number of Products by Stage and Target, H1 2015 26

Number of Products by Stage and Mechanism of Action, H1 2015 28

Number of Products by Stage and Route of Administration, H1 2015 30

Number of Products by Stage and Molecule Type, H1 2015 32

Interstitial Cystitis (Painful Bladder Syndrome) Therapeutics-Recent Pipeline Updates, H1 2015 53

Interstitial Cystitis (Painful Bladder Syndrome)-Dormant Projects, H1 2015 58

Interstitial Cystitis (Painful Bladder Syndrome)-Discontinued Products, H1 2015 59

List of Figures

Number of Products under Development for Interstitial Cystitis (Painful Bladder Syndrome), H1 2015 8

Number of Products under Development for Interstitial Cystitis (Painful Bladder Syndrome)-Comparative Analysis, H1 2015 9

Number of Products under Development by Companies, H1 2015 10

Comparative Analysis by Early Stage Products, H1 2015 13

Assessment by Monotherapy Products, H1 2015 23

Number of Products by Top 10 Targets, H1 2015 25

Number of Products by Stage and Top 10 Targets, H1 2015 26

Number of Products by Top 10 Mechanism of Actions, H1 2015 27

Number of Products by Stage and Top 10 Mechanism of Actions, H1 2015 28

Number of Products by Top 10 Routes of Administration, H1 2015 29

Number of Products by Stage and Top 10 Routes of Administration, H1 2015 30

Number of Products by Top 10 Molecule Types, H1 2015 31

Number of Products by Stage and Top 10 Molecule Types, H1 2015 32

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Afferent Pharmaceuticals, Inc.

Allergan, Inc.

Aquinox Pharmaceuticals Inc.

Kytogenics Pharmaceuticals, Inc.

Lipella Pharmaceuticals, Inc.

Qu Biologics Inc.

Urigen Pharmaceuticals, Inc.

Interstitial Cystitis (Painful Bladder Syndrome) Therapeutic Products under Development, Key Players in Interstitial Cystitis (Painful Bladder Syndrome) Therapeutics, Interstitial Cystitis (Painful Bladder Syndrome) Pipeline Overview, Interstitial Cystitis (Painful Bladder Syndrome) Pipeline, Interstitial Cystitis (Painful Bladder Syndrome) Pipeline Assessment


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