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Osteoarthritis-Pipeline Review, H1 2015

Osteoarthritis-Pipeline Review, H1 2015


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Executive Summary

Osteoarthritis-Pipeline Review, H1 2015

Summary

Global Markets Direct's, 'Osteoarthritis-Pipeline Review, H1 2015', provides an overview of the Osteoarthritis's therapeutic pipeline.

This report provides comprehensive information on the therapeutic development for Osteoarthritis, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Osteoarthritis and special features on late-stage and discontinued projects.

Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis.

The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.

Scope

The report provides a snapshot of the global therapeutic landscape of Osteoarthritis

The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities

The report reviews key players involved in the therapeutics development for Osteoarthritis and enlists all their major and minor projects

The report summarizes all the dormant and discontinued pipeline projects

A review of the Osteoarthritis products under development by companies and universities/research institutes based on information derived from company and industry-specific sources

Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages

A detailed assessment of monotherapy and combination therapy pipeline projects

Coverage of the Osteoarthritis pipeline on the basis of target, MoA, route of administration and molecule type

Latest news and deals relating related to pipeline products

Reasons To Buy

Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies

Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage

Develop strategic initiatives by understanding the focus areas of leading companies

Identify and understand important and diverse types of therapeutics under development for Osteoarthritis

Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline

Devise corrective measures for pipeline projects by understanding Osteoarthritis pipeline depth and focus of Indication therapeutics

Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline

Table of Contents

Table of Contents 2

Introduction 7

Osteoarthritis Overview 8

Therapeutics Development 9

Osteoarthritis-Therapeutics under Development by Companies 11

Osteoarthritis-Therapeutics under Investigation by Universities/Institutes 18

Osteoarthritis-Pipeline Products Glance 20

Osteoarthritis-Products under Development by Companies 23

Osteoarthritis-Products under Investigation by Universities/Institutes 30

Osteoarthritis-Companies Involved in Therapeutics Development 31

Osteoarthritis-Therapeutics Assessment 90

Drug Profiles 109

Osteoarthritis-Recent Pipeline Updates 251

Osteoarthritis-Dormant Projects 288

Osteoarthritis-Discontinued Products 296

Osteoarthritis-Product Development Milestones 298

Appendix 304

List of Tables

Number of Products under Development for Osteoarthritis, H1 2015 22

Number of Products under Development for Osteoarthritis-Comparative Analysis, H1 2015 23

Number of Products under Development by Companies, H1 2015 25

Number of Products under Development by Companies, H1 2015 (Contd..1) 26

Number of Products under Development by Companies, H1 2015 (Contd..2) 27

Number of Products under Development by Companies, H1 2015 (Contd..3) 28

Number of Products under Development by Companies, H1 2015 (Contd..4) 29

Number of Products under Development by Companies, H1 2015 (Contd..5) 30

Number of Products under Investigation by Universities/Institutes, H1 2015 32

Comparative Analysis by Late Stage Development, H1 2015 33

Comparative Analysis by Clinical Stage Development, H1 2015 34

Comparative Analysis by Early Stage Development, H1 2015 35

Products under Development by Companies, H1 2015 36

Products under Development by Companies, H1 2015 (Contd..1) 37

Products under Development by Companies, H1 2015 (Contd..2) 38

Products under Development by Companies, H1 2015 (Contd..3) 39

Products under Development by Companies, H1 2015 (Contd..4) 40

Products under Development by Companies, H1 2015 (Contd..5) 41

Products under Development by Companies, H1 2015 (Contd..6) 42

Products under Investigation by Universities/Institutes, H1 2015 43

Osteoarthritis-Pipeline by A. Menarini Industrie Farmaceutiche Riunite Srl, H1 2015 44

Osteoarthritis-Pipeline by AbbVie Inc., H1 2015 45

Osteoarthritis-Pipeline by Abiogen Pharma S.p.A., H1 2015 46

Osteoarthritis-Pipeline by Addex Therapeutics Ltd, H1 2015 47

Osteoarthritis-Pipeline by Ampio Pharmaceuticals, Inc., H1 2015 48

Osteoarthritis-Pipeline by Amura Holdings Limited, H1 2015 49

Osteoarthritis-Pipeline by Arcarios BV, H1 2015 50

Osteoarthritis-Pipeline by Asklepios BioPharmaceutical, Inc., H1 2015 51

Osteoarthritis-Pipeline by Astellas Pharma Inc., H1 2015 52

Osteoarthritis-Pipeline by Biomet Biologics, LLC, H1 2015 53

Osteoarthritis-Pipeline by Biopharm GmbH, H1 2015 54

Osteoarthritis-Pipeline by Can-Fite BioPharma Ltd., H1 2015 55

Osteoarthritis-Pipeline by Cardax Pharmaceuticals, Inc., H1 2015 56

Osteoarthritis-Pipeline by Celgene Corporation, H1 2015 57

Osteoarthritis-Pipeline by Cellceutix Corporation, H1 2015 58

Osteoarthritis-Pipeline by Cellular Biomedicine Group, Inc., H1 2015 59

Osteoarthritis-Pipeline by Celsus Therapeutics Plc, H1 2015 60

Osteoarthritis-Pipeline by Chong Kun Dang Pharmaceutical Corp., H1 2015 61

Osteoarthritis-Pipeline by Eli Lilly and Company, H1 2015 62

Osteoarthritis-Pipeline by Galapagos NV, H1 2015 63

Osteoarthritis-Pipeline by GeneFrontier Corporation, H1 2015 64

Osteoarthritis-Pipeline by Genequine Biotherapeutics GmbH, H1 2015 65

Osteoarthritis-Pipeline by GlaxoSmithKline Plc, H1 2015 66

Osteoarthritis-Pipeline by IMMD Inc., H1 2015 67

Osteoarthritis-Pipeline by IntelliCell BioSciences Inc., H1 2015 68

Osteoarthritis-Pipeline by Jeil Pharmaceutical Co., Ltd., H1 2015 69

Osteoarthritis-Pipeline by Jenrin Discovery, Inc., H1 2015 70

Osteoarthritis-Pipeline by K-Stemcell Co., Ltd., H1 2015 71

Osteoarthritis-Pipeline by Laila Pharmaceuticals Pvt. Ltd., H1 2015 72

Osteoarthritis-Pipeline by Levolta Pharmaceuticals, Inc., H1 2015 73

Osteoarthritis-Pipeline by Medivir AB, H1 2015 74

Osteoarthritis-Pipeline by Merck KGaA, H1 2015 75

Osteoarthritis-Pipeline by Mesoblast Limited, H1 2015 76

Osteoarthritis-Pipeline by Mor Research Application Ltd, H1 2015 77

Osteoarthritis-Pipeline by NicOx S.A., H1 2015 78

Osteoarthritis-Pipeline by Nordic Bioscience A/S, H1 2015 79

Osteoarthritis-Pipeline by Novartis AG, H1 2015 80

Osteoarthritis-Pipeline by Ocata Therapeutics, Inc., H1 2015 81

Osteoarthritis-Pipeline by Omeros Corporation, H1 2015 82

Osteoarthritis-Pipeline by Ono Pharmaceutical Co., Ltd., H1 2015 83

Osteoarthritis-Pipeline by OrthoCyte Corporation, H1 2015 84

Osteoarthritis-Pipeline by Osteologix Holdings Plc, H1 2015 85

Osteoarthritis-Pipeline by Pharmalink AB, H1 2015 86

Osteoarthritis-Pipeline by PolyNovo Limited, H1 2015 87

Osteoarthritis-Pipeline by ReqMed Company, Ltd., H1 2015 88

Osteoarthritis-Pipeline by Rottapharm SpA, H1 2015 89

Osteoarthritis-Pipeline by Sanofi, H1 2015 90

Osteoarthritis-Pipeline by Seikagaku Corporation, H1 2015 91

Osteoarthritis-Pipeline by Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., H1 2015 92

Osteoarthritis-Pipeline by STELIS Biopharma Pvt. Ltd., H1 2015 93

Osteoarthritis-Pipeline by Stempeutics Research Private Limited, H1 2015 94

Osteoarthritis-Pipeline by Symic Biomedical, Inc., H1 2015 95

Osteoarthritis-Pipeline by Takeda Pharmaceutical Company Limited, H1 2015 96

Osteoarthritis-Pipeline by TissueGene, Inc., H1 2015 97

Osteoarthritis-Pipeline by TOKUHON Corporation, H1 2015 98

Osteoarthritis-Pipeline by Upsher-Smith Laboratories, Inc., H1 2015 99

Osteoarthritis-Pipeline by Yooyoung Pharmaceutical Co., Ltd., H1 2015 100

Osteoarthritis-Pipeline by Yuhan Corporation, H1 2015 101

Osteoarthritis-Pipeline by Yungjin Pharm Ind. Co., Ltd., H1 2015 102

Assessment by Monotherapy Products, H1 2015 103

Assessment by Combination Products, H1 2015 104

Number of Products by Stage and Target, H1 2015 107

Number of Products by Stage and Mechanism of Action, H1 2015 113

Number of Products by Stage and Route of Administration, H1 2015 118

Number of Products by Stage and Molecule Type, H1 2015 121

Osteoarthritis Therapeutics-Recent Pipeline Updates, H1 2015 264

Osteoarthritis-Dormant Projects, H1 2015 301

Osteoarthritis-Dormant Projects (Contd..1), H1 2015 302

Osteoarthritis-Dormant Projects (Contd..2), H1 2015 303

Osteoarthritis-Dormant Projects (Contd..3), H1 2015 304

Osteoarthritis-Dormant Projects (Contd..4), H1 2015 305

Osteoarthritis-Dormant Projects (Contd..5), H1 2015 306

Osteoarthritis-Dormant Projects (Contd..6), H1 2015 307

Osteoarthritis-Dormant Projects (Contd..7), H1 2015 308

Osteoarthritis-Discontinued Products, H1 2015 309

Osteoarthritis-Discontinued Products (Contd..1), H1 2015 310

List of Figures

Number of Products under Development for Osteoarthritis, H1 2015 22

Number of Products under Development for Osteoarthritis-Comparative Analysis, H1 2015 23

Number of Products under Development by Companies, H1 2015 24

Number of Products under Investigation by Universities/Institutes, H1 2015 31

Comparative Analysis by Late Stage Development, H1 2015 33

Comparative Analysis by Clinical Stage Development, H1 2015 34

Comparative Analysis by Early Stage Products, H1 2015 35

Assessment by Monotherapy Products, H1 2015 103

Assessment by Combination Products, H1 2015 104

Number of Products by Top 10 Targets, H1 2015 105

Number of Products by Stage and Top 10 Targets, H1 2015 106

Number of Products by Top 10 Mechanism of Actions, H1 2015 111

Number of Products by Stage and Top 10 Mechanism of Actions, H1 2015 112

Number of Products by Top 10 Routes of Administration, H1 2015 116

Number of Products by Stage and Top 10 Routes of Administration, H1 2015 117

Number of Products by Top 10 Molecule Types, H1 2015 119

Number of Products by Stage and Top 10 Molecule Types, H1 2015 120

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A. Menarini Industrie Farmaceutiche Riunite Srl

AbbVie Inc.

Abiogen Pharma S.p.A.

Addex Therapeutics Ltd

Ampio Pharmaceuticals, Inc.

Amura Holdings Limited

Arcarios BV

Asklepios BioPharmaceutical, Inc.

Astellas Pharma Inc.

Biomet Biologics, LLC

Biopharm GmbH

Can-Fite BioPharma Ltd.

Cardax Pharmaceuticals, Inc.

Celgene Corporation

Cellceutix Corporation

Cellular Biomedicine Group, Inc.

Celsus Therapeutics Plc

Chong Kun Dang Pharmaceutical Corp.

Eli Lilly and Company

Galapagos NV

GeneFrontier Corporation

Genequine Biotherapeutics GmbH

GlaxoSmithKline Plc

IMMD Inc.

IntelliCell BioSciences Inc.

Jeil Pharmaceutical Co., Ltd.

Jenrin Discovery, Inc.

K-Stemcell Co., Ltd.

Laila Pharmaceuticals Pvt. Ltd.

Levolta Pharmaceuticals, Inc.

Medivir AB

Merck KGaA

Mesoblast Limited

Mor Research Application Ltd

NicOx S.A.

Nordic Bioscience A/S

Novartis AG

Ocata Therapeutics, Inc.

Omeros Corporation

Ono Pharmaceutical Co., Ltd.

OrthoCyte Corporation

Osteologix Holdings Plc

Pharmalink AB

PolyNovo Limited

ReqMed Company, Ltd.

Rottapharm SpA

Sanofi

Seikagaku Corporation

Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.

STELIS Biopharma Pvt. Ltd.

Stempeutics Research Private Limited

Symic Biomedical, Inc.

Takeda Pharmaceutical Company Limited

TissueGene, Inc.

TOKUHON Corporation

Upsher-Smith Laboratories, Inc.

Yooyoung Pharmaceutical Co., Ltd.

Yuhan Corporation

Yungjin Pharm Ind. Co., Ltd.

Osteoarthritis Therapeutic Products under Development, Key Players in Osteoarthritis Therapeutics, Osteoarthritis Pipeline Overview, Osteoarthritis Pipeline, Osteoarthritis Pipeline Assessment


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