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Portal Hypertension-Pipeline Review, H1 2015

Portal Hypertension-Pipeline Review, H1 2015


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Executive Summary

Portal Hypertension-Pipeline Review, H1 2015

Summary

Global Markets Direct's, 'Portal Hypertension-Pipeline Review, H1 2015', provides an overview of the Portal Hypertension's therapeutic pipeline.

This report provides comprehensive information on the therapeutic development for Portal Hypertension, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Portal Hypertension and special features on late-stage and discontinued projects.

Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis.

The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.

Scope

The report provides a snapshot of the global therapeutic landscape of Portal Hypertension

The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities

The report reviews key players involved in the therapeutics development for Portal Hypertension and enlists all their major and minor projects

The report summarizes all the dormant and discontinued pipeline projects

A review of the Portal Hypertension products under development by companies and universities/research institutes based on information derived from company and industry-specific sources

Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages

A detailed assessment of monotherapy and combination therapy pipeline projects

Coverage of the Portal Hypertension pipeline on the basis of target, MoA, route of administration and molecule type

Latest news and deals relating related to pipeline products

Reasons To Buy

Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies

Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage

Develop strategic initiatives by understanding the focus areas of leading companies

Identify and understand important and diverse types of therapeutics under development for Portal Hypertension

Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline

Devise corrective measures for pipeline projects by understanding Portal Hypertension pipeline depth and focus of Indication therapeutics

Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline

Table of Contents

Table of Contents 2

List of Tables 4

List of Figures 4

Introduction 5

Global Markets Direct Report Coverage 5

Portal Hypertension Overview 6

Therapeutics Development 7

Pipeline Products for Portal Hypertension-Overview 7

Pipeline Products for Portal Hypertension-Comparative Analysis 8

Portal Hypertension-Therapeutics under Development by Companies 9

Portal Hypertension-Pipeline Products Glance 10

Clinical Stage Products 10

Early Stage Products 11

Portal Hypertension-Products under Development by Companies 12

Portal Hypertension-Companies Involved in Therapeutics Development 13

Conatus Pharmaceuticals Inc. 13

Intercept Pharmaceuticals, Inc. 14

Mezzion Pharma Co. Ltd. 15

Ono Pharmaceutical Co., Ltd. 16

Phenex Pharmaceuticals AG 17

Portal Hypertension-Therapeutics Assessment 18

Assessment by Monotherapy Products 18

Assessment by Target 19

Assessment by Mechanism of Action 21

Assessment by Route of Administration 23

Assessment by Molecule Type 24

Drug Profiles 25

emricasan-Drug Profile 25

Product Description 25

Mechanism of Action 25

R&D Progress 25

obeticholic acid-Drug Profile 27

Product Description 27

Mechanism of Action 27

R&D Progress 27

ONO-1266-Drug Profile 30

Product Description 30

Mechanism of Action 30

R&D Progress 30

PX-20606-Drug Profile 31

Product Description 31

Mechanism of Action 31

R&D Progress 31

udenafil-Drug Profile 32

Product Description 32

Mechanism of Action 32

R&D Progress 32

Portal Hypertension-Recent Pipeline Updates 34

Portal Hypertension-Dormant Projects 42

Portal Hypertension-Discontinued Products 43

Portal Hypertension-Product Development Milestones 44

Featured News & Press Releases 44

Nov 10, 2014: Conatus Pharmaceuticals Presents Late-Breaking Poster At AASLD Annual Meeting 44

Oct 08, 2014: Conatus Pharmaceuticals Announces Acceptance Of Late-Breaking Abstract For AASLD Annual Meeting 45

Sep 02, 2014: Conatus Pharmaceuticals Initiates Phase 2 Trial in Patients with Liver Cirrhosis and Separate Open Label Phase 2 Trial in Cirrhosis Patients with Portal Hypertension 46

Nov 08, 2012: Intercept Pharma To Present Phase IIa Portal Hypertension Data At AASLD's Annual Liver Meeting 47

Appendix 48

Methodology 48

Coverage 48

Secondary Research 48

Primary Research 48

Expert Panel Validation 48

Contact Us 48

Disclaimer 49

List of Tables

Number of Products under Development for Portal Hypertension, H1 2015 7

Number of Products under Development for Portal Hypertension-Comparative Analysis, H1 2015 8

Number of Products under Development by Companies, H1 2015 9

Comparative Analysis by Clinical Stage Development, H1 2015 10

Comparative Analysis by Early Stage Development, H1 2015 11

Products under Development by Companies, H1 2015 12

Portal Hypertension-Pipeline by Conatus Pharmaceuticals Inc., H1 2015 13

Portal Hypertension-Pipeline by Intercept Pharmaceuticals, Inc., H1 2015 14

Portal Hypertension-Pipeline by Mezzion Pharma Co. Ltd., H1 2015 15

Portal Hypertension-Pipeline by Ono Pharmaceutical Co., Ltd., H1 2015 16

Portal Hypertension-Pipeline by Phenex Pharmaceuticals AG, H1 2015 17

Assessment by Monotherapy Products, H1 2015 18

Number of Products by Stage and Target, H1 2015 20

Number of Products by Stage and Mechanism of Action, H1 2015 22

Number of Products by Stage and Route of Administration, H1 2015 23

Number of Products by Stage and Molecule Type, H1 2015 24

Portal Hypertension Therapeutics-Recent Pipeline Updates, H1 2015 34

Portal Hypertension-Dormant Projects, H1 2015 42

Portal Hypertension-Discontinued Products, H1 2015 43

List of Figures

Number of Products under Development for Portal Hypertension, H1 2015 7

Number of Products under Development for Portal Hypertension-Comparative Analysis, H1 2015 8

Number of Products under Development by Companies, H1 2015 9

Comparative Analysis by Clinical Stage Development, H1 2015 10

Assessment by Monotherapy Products, H1 2015 18

Number of Products by Top 10 Targets, H1 2015 19

Number of Products by Stage and Top 10 Targets, H1 2015 20

Number of Products by Top 10 Mechanism of Actions, H1 2015 21

Number of Products by Stage and Top 10 Mechanism of Actions, H1 2015 22

Number of Products by Stage and Top 10 Routes of Administration, H1 2015 23

Number of Products by Stage and Top 10 Molecule Types, H1 2015 24

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Conatus Pharmaceuticals Inc.

Intercept Pharmaceuticals, Inc.

Mezzion Pharma Co. Ltd.

Ono Pharmaceutical Co., Ltd.

Phenex Pharmaceuticals AG

Portal Hypertension Therapeutic Products under Development, Key Players in Portal Hypertension Therapeutics, Portal Hypertension Pipeline Overview, Portal Hypertension Pipeline, Portal Hypertension Pipeline Assessment


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