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Postherpetic Neuralgia-Pipeline Review, H1 2015

Postherpetic Neuralgia-Pipeline Review, H1 2015

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Executive Summary

Postherpetic Neuralgia-Pipeline Review, H1 2015


Global Markets Direct's, 'Postherpetic Neuralgia-Pipeline Review, H1 2015', provides an overview of the Postherpetic Neuralgia's therapeutic pipeline.

This report provides comprehensive information on the therapeutic development for Postherpetic Neuralgia, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Postherpetic Neuralgia and special features on late-stage and discontinued projects.

Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis.

The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.


The report provides a snapshot of the global therapeutic landscape of Postherpetic Neuralgia

The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities

The report reviews key players involved in the therapeutics development for Postherpetic Neuralgia and enlists all their major and minor projects

The report summarizes all the dormant and discontinued pipeline projects

A review of the Postherpetic Neuralgia products under development by companies and universities/research institutes based on information derived from company and industry-specific sources

Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages

A detailed assessment of monotherapy and combination therapy pipeline projects

Coverage of the Postherpetic Neuralgia pipeline on the basis of target, MoA, route of administration and molecule type

Latest news and deals relating related to pipeline products

Reasons To Buy

Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies

Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage

Develop strategic initiatives by understanding the focus areas of leading companies

Identify and understand important and diverse types of therapeutics under development for Postherpetic Neuralgia

Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline

Devise corrective measures for pipeline projects by understanding Postherpetic Neuralgia pipeline depth and focus of Indication therapeutics

Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline

Table of Contents

Table of Contents 2

List of Tables 6

List of Figures 7

Introduction 8

Global Markets Direct Report Coverage 8

Postherpetic Neuralgia Overview 9

Therapeutics Development 10

Pipeline Products for Postherpetic Neuralgia-Overview 10

Pipeline Products for Postherpetic Neuralgia-Comparative Analysis 11

Postherpetic Neuralgia-Therapeutics under Development by Companies 12

Postherpetic Neuralgia-Pipeline Products Glance 14

Late Stage Products 14

Clinical Stage Products 15

Early Stage Products 16

Unknown Stage Products 17

Postherpetic Neuralgia-Products under Development by Companies 18

Postherpetic Neuralgia-Companies Involved in Therapeutics Development 20

Aestus Therapeutics, Inc. 20

Allergan, Inc. 21

Arcion Therapeutics, Inc. 22

Astellas Pharma Inc. 23

Daewoong Pharmaceutical Co., Ltd. 24

Daiichi Sankyo Company, Limited 25

Immune Pharmaceuticals, Ltd. 26

Intellipharmaceutics International Inc. 27

Merck & Co., Inc. 28

NeurAxon, Inc. 29

Nuvo Research Inc. 30

Pfizer Inc. 31

Phosphagenics Limited 32

Purdue Pharma L.P. 33

Relmada Therapeutics, Inc. 34

Scilex Pharmaceuticals, Inc. 35

Spinifex Pharmaceuticals Pty Limited 36

Teva Pharmaceutical Industries Limited 37

Winston Pharmaceuticals, Inc. 38

Postherpetic Neuralgia-Therapeutics Assessment 39

Assessment by Monotherapy Products 39

Assessment by Combination Products 40

Assessment by Target 41

Assessment by Mechanism of Action 43

Assessment by Route of Administration 45

Assessment by Molecule Type 47

Drug Profiles 49

(amitriptyline + ketamine hydrochloride)-Drug Profile 49

Product Description 49

Mechanism of Action 49

R&D Progress 49

(naltrexone hydrochloride+ clonidine hydrochloride)-Drug Profile 51

Product Description 51

Mechanism of Action 51

R&D Progress 51

ASP-8477-Drug Profile 52

Product Description 52

Mechanism of Action 52

R&D Progress 52

Atx08-001-Drug Profile 53

Product Description 53

Mechanism of Action 53

R&D Progress 53

bupivacaine hydrochloride-Drug Profile 55

Product Description 55

Mechanism of Action 55

R&D Progress 55

C-746-Drug Profile 57

Product Description 57

Mechanism of Action 57

R&D Progress 57

CNV-2197944-Drug Profile 58

Product Description 58

Mechanism of Action 58

R&D Progress 58

DWP-05195-Drug Profile 60

Product Description 60

Mechanism of Action 60

R&D Progress 60

EMA-401-Drug Profile 61

Product Description 61

Mechanism of Action 61

R&D Progress 61

Flexicaine-Drug Profile 63

Product Description 63

Mechanism of Action 63

R&D Progress 63

FV-100-Drug Profile 64

Product Description 64

Mechanism of Action 64

R&D Progress 64

ketoprofen-Drug Profile 66

Product Description 66

Mechanism of Action 66

R&D Progress 66

lidocaine-Drug Profile 67

Product Description 67

Mechanism of Action 67

R&D Progress 67

lidocaine hydrochloride-Drug Profile 68

Product Description 68

Mechanism of Action 68

R&D Progress 68

mepivacaine hydrochloride-Drug Profile 69

Product Description 69

Mechanism of Action 69

R&D Progress 69

mirogabalin-Drug Profile 70

Product Description 70

Mechanism of Action 70

R&D Progress 70

MK-8291-Drug Profile 72

Product Description 72

Mechanism of Action 72

R&D Progress 72

NXN-462-Drug Profile 73

Product Description 73

Mechanism of Action 73

R&D Progress 73

oxycodone ER-Drug Profile 74

Product Description 74

Mechanism of Action 74

R&D Progress 74

pregabalin CR-Drug Profile 76

Product Description 76

Mechanism of Action 76

R&D Progress 76

pregabalin ER-Drug Profile 77

Product Description 77

Mechanism of Action 77

R&D Progress 77

senrebotase-Drug Profile 78

Product Description 78

Mechanism of Action 78

R&D Progress 78

TV-45070-Drug Profile 79

Product Description 79

Mechanism of Action 79

R&D Progress 79

V-116517-Drug Profile 80

Product Description 80

Mechanism of Action 80

R&D Progress 80

zucapsaicin-Drug Profile 81

Product Description 81

Mechanism of Action 81

R&D Progress 81

Postherpetic Neuralgia-Recent Pipeline Updates 83

Postherpetic Neuralgia-Dormant Projects 97

Postherpetic Neuralgia-Discontinued Products 99

Postherpetic Neuralgia-Product Development Milestones 100

Featured News & Press Releases 100

Apr 02, 2015: Teva and Xenon Announce Enrollment of First Patient in a Phase 2b Study Evaluating TV-45070 for Postherpetic Neuralgia 100

Feb 20, 2015: ContraVir Pharmaceuticals Provides Clinical Update on FV-100 100

Feb 19, 2015: Xenon Pharmaceuticals Partner Teva to Initiate Phase 2b Clinical Trial of TV-45070 in Post-Herpetic Neuralgia 101

Feb 04, 2015: Daiichi Sankyo Announces First Patients in Large-scale, Multi-national Phase 3 Clinical Programs for Mirogabalin 101

Jan 07, 2015: ContraVir Pharmaceuticals Granted FDA Meeting to Discuss Proposal for Phase 3 Trial of FV-100 102

Dec 18, 2014: Pfizer Reports Top-Line Results From a Phase 3 Study Evaluating Pregabalin Controlled-Release Formulation as a Treatment for Patients With Postherpetic Neuralgia 103

Aug 11, 2014: Scilex Pharmaceuticals Completes Trial Enrollment for Ztlido 103

Jul 14, 2014: SCILEX Pharmaceuticals Commences Dermal Safety Studies of Ztlido 104

May 19, 2014: Scilex Pharmaceuticals Initiates Pivotal Pharmacokinetic Study for Ztilido 104

Mar 24, 2014: Scilex Pharmaceuticals Announces Filing of Investigational New Drug Application for Ztilido 105

Appendix 106

Methodology 106

Coverage 106

Secondary Research 106

Primary Research 106

Expert Panel Validation 106

Contact Us 106

Disclaimer 107

List of Tables

Number of Products under Development for Postherpetic Neuralgia, H1 2015 10

Number of Products under Development for Postherpetic Neuralgia-Comparative Analysis, H1 2015 11

Number of Products under Development by Companies, H1 2015 13

Comparative Analysis by Late Stage Development, H1 2015 14

Comparative Analysis by Clinical Stage Development, H1 2015 15

Comparative Analysis by Early Stage Development, H1 2015 16

Comparative Analysis by Unknown Stage Development, H1 2015 17

Products under Development by Companies, H1 2015 18

Products under Development by Companies, H1 2015 (Contd..1) 19

Postherpetic Neuralgia-Pipeline by Aestus Therapeutics, Inc., H1 2015 20

Postherpetic Neuralgia-Pipeline by Allergan, Inc., H1 2015 21

Postherpetic Neuralgia-Pipeline by Arcion Therapeutics, Inc., H1 2015 22

Postherpetic Neuralgia-Pipeline by Astellas Pharma Inc., H1 2015 23

Postherpetic Neuralgia-Pipeline by Daewoong Pharmaceutical Co., Ltd., H1 2015 24

Postherpetic Neuralgia-Pipeline by Daiichi Sankyo Company, Limited, H1 2015 25

Postherpetic Neuralgia-Pipeline by Immune Pharmaceuticals, Ltd., H1 2015 26

Postherpetic Neuralgia-Pipeline by Intellipharmaceutics International Inc., H1 2015 27

Postherpetic Neuralgia-Pipeline by Merck & Co., Inc., H1 2015 28

Postherpetic Neuralgia-Pipeline by NeurAxon, Inc., H1 2015 29

Postherpetic Neuralgia-Pipeline by Nuvo Research Inc., H1 2015 30

Postherpetic Neuralgia-Pipeline by Pfizer Inc., H1 2015 31

Postherpetic Neuralgia-Pipeline by Phosphagenics Limited, H1 2015 32

Postherpetic Neuralgia-Pipeline by Purdue Pharma L.P., H1 2015 33

Postherpetic Neuralgia-Pipeline by Relmada Therapeutics, Inc., H1 2015 34

Postherpetic Neuralgia-Pipeline by Scilex Pharmaceuticals, Inc., H1 2015 35

Postherpetic Neuralgia-Pipeline by Spinifex Pharmaceuticals Pty Limited, H1 2015 36

Postherpetic Neuralgia-Pipeline by Teva Pharmaceutical Industries Limited, H1 2015 37

Postherpetic Neuralgia-Pipeline by Winston Pharmaceuticals, Inc., H1 2015 38

Assessment by Monotherapy Products, H1 2015 39

Assessment by Combination Products, H1 2015 40

Number of Products by Stage and Target, H1 2015 42

Number of Products by Stage and Mechanism of Action, H1 2015 44

Number of Products by Stage and Route of Administration, H1 2015 46

Number of Products by Stage and Molecule Type, H1 2015 48

Postherpetic Neuralgia Therapeutics-Recent Pipeline Updates, H1 2015 83

Postherpetic Neuralgia-Dormant Projects, H1 2015 97

Postherpetic Neuralgia-Dormant Projects (Contd..1), H1 2015 98

Postherpetic Neuralgia-Discontinued Products, H1 2015 99

List of Figures

Number of Products under Development for Postherpetic Neuralgia, H1 2015 10

Number of Products under Development for Postherpetic Neuralgia-Comparative Analysis, H1 2015 11

Number of Products under Development by Companies, H1 2015 12

Comparative Analysis by Clinical Stage Development, H1 2015 15

Assessment by Monotherapy Products, H1 2015 39

Assessment by Combination Products, H1 2015 40

Number of Products by Top 10 Targets, H1 2015 41

Number of Products by Stage and Top 10 Targets, H1 2015 41

Number of Products by Top 10 Mechanism of Actions, H1 2015 43

Number of Products by Stage and Top 10 Mechanism of Actions, H1 2015 43

Number of Products by Top 10 Routes of Administration, H1 2015 45

Number of Products by Stage and Top 10 Routes of Administration, H1 2015 46

Number of Products by Top 10 Molecule Types, H1 2015 47

Number of Products by Stage and Top 10 Molecule Types, H1 2015 48

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To know more information on Purchase by Section, please send a mail to query [@]

Aestus Therapeutics, Inc.

Allergan, Inc.

Arcion Therapeutics, Inc.

Astellas Pharma Inc.

Daewoong Pharmaceutical Co., Ltd.

Daiichi Sankyo Company, Limited

Immune Pharmaceuticals, Ltd.

Intellipharmaceutics International Inc.

Merck & Co., Inc.

NeurAxon, Inc.

Nuvo Research Inc.

Pfizer Inc.

Phosphagenics Limited

Purdue Pharma L.P.

Relmada Therapeutics, Inc.

Scilex Pharmaceuticals, Inc.

Spinifex Pharmaceuticals Pty Limited

Teva Pharmaceutical Industries Limited

Winston Pharmaceuticals, Inc.

Postherpetic Neuralgia Therapeutic Products under Development, Key Players in Postherpetic Neuralgia Therapeutics, Postherpetic Neuralgia Pipeline Overview, Postherpetic Neuralgia Pipeline, Postherpetic Neuralgia Pipeline Assessment

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