Proliferative Vitreoretinopathy (PVR)-Pipeline Review, H2 2015

Proliferative Vitreoretinopathy (PVR)-Pipeline Review, H2 2015


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Executive Summary

Proliferative Vitreoretinopathy (PVR)-Pipeline Review, H2 2015

Summary

Global Markets Direct's, 'Proliferative Vitreoretinopathy (PVR)-Pipeline Review, H2 2015', provides an overview of the Proliferative Vitreoretinopathy (PVR)'s therapeutic pipeline.

This report provides comprehensive information on the therapeutic development for Proliferative Vitreoretinopathy (PVR), complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Proliferative Vitreoretinopathy (PVR) and special features on late-stage and discontinued projects.

Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis.

The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.

Scope

The report provides a snapshot of the global therapeutic landscape of Proliferative Vitreoretinopathy (PVR)

The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities

The report reviews key players involved in the therapeutics development for Proliferative Vitreoretinopathy (PVR) and enlists all their major and minor projects

The report summarizes all the dormant and discontinued pipeline projects

A review of the Proliferative Vitreoretinopathy (PVR) products under development by companies and universities/research institutes based on information derived from company and industry-specific sources

Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages

A detailed assessment of monotherapy and combination therapy pipeline projects

Coverage of the Proliferative Vitreoretinopathy (PVR) pipeline on the basis of target, MoA, route of administration and molecule type

Latest news and deals relating related to pipeline products

Reasons To Buy

Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies

Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage

Develop strategic initiatives by understanding the focus areas of leading companies

Identify and understand important and diverse types of therapeutics under development for Proliferative Vitreoretinopathy (PVR)

Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline

Devise corrective measures for pipeline projects by understanding Proliferative Vitreoretinopathy (PVR) pipeline depth and focus of Indication therapeutics

Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline



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Table of Contents

Table of Contents 2

List of Tables 4

List of Figures 4

Introduction 5

Global Markets Direct Report Coverage 5

Proliferative Vitreoretinopathy (PVR) Overview 6

Therapeutics Development 7

Pipeline Products for Proliferative Vitreoretinopathy (PVR)-Overview 7

Pipeline Products for Proliferative Vitreoretinopathy (PVR)-Comparative Analysis 8

Proliferative Vitreoretinopathy (PVR)-Therapeutics under Development by Companies 9

Proliferative Vitreoretinopathy (PVR)-Therapeutics under Investigation by Universities/Institutes 10

Proliferative Vitreoretinopathy (PVR)-Pipeline Products Glance 11

Early Stage Products 11

Proliferative Vitreoretinopathy (PVR)-Products under Development by Companies 12

Proliferative Vitreoretinopathy (PVR)-Products under Investigation by Universities/Institutes 13

Proliferative Vitreoretinopathy (PVR)-Companies Involved in Therapeutics Development 14

Promedior, Inc. 14

RXi Pharmaceuticals Corporation 15

Proliferative Vitreoretinopathy (PVR)-Therapeutics Assessment 16

Assessment by Monotherapy Products 16

Assessment by Target 17

Assessment by Mechanism of Action 19

Assessment by Route of Administration 21

Assessment by Molecule Type 22

Drug Profiles 24

Drug to Inhibit TAK1 for Proliferative Vitreoretinopathy-Drug Profile 24

Product Description 24

Mechanism of Action 24

R&D Progress 24

LD-224-Drug Profile 25

Product Description 25

Mechanism of Action 25

R&D Progress 25

Oligonucleotide 2 for Age Related Macular Degeneration and Proliferative Vitreoretinopathy-Drug Profile 27

Product Description 27

Mechanism of Action 27

R&D Progress 27

Oligonucleotide for Age Related Macular Degeneration and Proliferative Vitreoretinopathy-Drug Profile 28

Product Description 28

Mechanism of Action 28

R&D Progress 28

PRM-167-Drug Profile 29

Product Description 29

Mechanism of Action 29

R&D Progress 29

RNAi Oligonucleotide to Inhibit CTGF for PVR-Drug Profile 30

Product Description 30

Mechanism of Action 30

R&D Progress 30

Small Molecules to Target Hdm2 for Proliferative Vitreoretinopathy-Drug Profile 31

Product Description 31

Mechanism of Action 31

R&D Progress 31

Proliferative Vitreoretinopathy (PVR)-Recent Pipeline Updates 32

Proliferative Vitreoretinopathy (PVR)-Dormant Projects 33

Proliferative Vitreoretinopathy (PVR)-Product Development Milestones 34

Featured News & Press Releases 34

Apr 27, 2015: RXi Pharmaceuticals Announces Upcoming Presentations at Leading Partnering and Scientific Conferences 34

May 22, 2014: RXi Pharmaceuticals Granted US Notice of Allowance Covering Self-Delivering (sd-rxRNA) Technology Platform 35

May 22, 2014: RXi Pharmaceuticals Granted US Notice of Allowance Covering Self-Delivering Technology Platform 36

May 07, 2012: Promedior Presents Preclinical Data Of Pentraxin-2 At ARVO Annual Meeting 36

May 01, 2012: Promedior To Present Preclinical Data Of Pentraxin-2 At ARVO Annual Meeting 37

Appendix 39

Methodology 39

Coverage 39

Secondary Research 39

Primary Research 39

Expert Panel Validation 39

Contact Us 39

Disclaimer 40

List of Tables

Number of Products under Development for Proliferative Vitreoretinopathy (PVR), H2 2015 7

Number of Products under Development for Proliferative Vitreoretinopathy (PVR)-Comparative Analysis, H2 2015 8

Number of Products under Development by Companies, H2 2015 9

Number of Products under Investigation by Universities/Institutes, H2 2015 10

Comparative Analysis by Early Stage Development, H2 2015 11

Products under Development by Companies, H2 2015 12

Products under Investigation by Universities/Institutes, H2 2015 13

Proliferative Vitreoretinopathy (PVR)-Pipeline by Promedior, Inc., H2 2015 14

Proliferative Vitreoretinopathy (PVR)-Pipeline by RXi Pharmaceuticals Corporation, H2 2015 15

Assessment by Monotherapy Products, H2 2015 16

Number of Products by Stage and Target, H2 2015 18

Number of Products by Stage and Mechanism of Action, H2 2015 20

Number of Products by Stage and Route of Administration, H2 2015 21

Number of Products by Stage and Molecule Type, H2 2015 23

Proliferative Vitreoretinopathy (PVR) Therapeutics-Recent Pipeline Updates, H2 2015 32

Proliferative Vitreoretinopathy (PVR)-Dormant Projects, H2 2015 33

List of Figures

Number of Products under Development for Proliferative Vitreoretinopathy (PVR), H2 2015 7

Number of Products under Development for Proliferative Vitreoretinopathy (PVR)-Comparative Analysis, H2 2015 8

Number of Products under Development by Companies, H2 2015 9

Number of Products under Investigation by Universities/Institutes, H2 2015 10

Comparative Analysis by Early Stage Products, H2 2015 11

Assessment by Monotherapy Products, H2 2015 16

Number of Products by Top 10 Targets, H2 2015 17

Number of Products by Stage and Top 10 Targets, H2 2015 17

Number of Products by Top 10 Mechanism of Actions, H2 2015 19

Number of Products by Stage and Top 10 Mechanism of Actions, H2 2015 19

Number of Products by Top 10 Molecule Types, H2 2015 22

Number of Products by Stage and Top 10 Molecule Types, H2 2015 22

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Promedior, Inc.

RXi Pharmaceuticals Corporation

Proliferative Vitreoretinopathy (PVR) Therapeutic Products under Development, Key Players in Proliferative Vitreoretinopathy (PVR) Therapeutics, Proliferative Vitreoretinopathy (PVR) Pipeline Overview, Proliferative Vitreoretinopathy (PVR) Pipeline, Proliferative Vitreoretinopathy (PVR) Pipeline Assessment

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