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Renal Anemia-Pipeline Review, H1 2015

Renal Anemia-Pipeline Review, H1 2015

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Executive Summary

Renal Anemia-Pipeline Review, H1 2015


Global Markets Direct's, 'Renal Anemia-Pipeline Review, H1 2015', provides an overview of the Renal Anemia's therapeutic pipeline.

This report provides comprehensive information on the therapeutic development for Renal Anemia, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Renal Anemia and special features on late-stage and discontinued projects.

Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis.

The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.


The report provides a snapshot of the global therapeutic landscape of Renal Anemia

The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities

The report reviews key players involved in the therapeutics development for Renal Anemia and enlists all their major and minor projects

The report summarizes all the dormant and discontinued pipeline projects

A review of the Renal Anemia products under development by companies and universities/research institutes based on information derived from company and industry-specific sources

Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages

A detailed assessment of monotherapy and combination therapy pipeline projects

Coverage of the Renal Anemia pipeline on the basis of target, MoA, route of administration and molecule type

Latest news and deals relating related to pipeline products

Reasons To Buy

Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies

Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage

Develop strategic initiatives by understanding the focus areas of leading companies

Identify and understand important and diverse types of therapeutics under development for Renal Anemia

Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline

Devise corrective measures for pipeline projects by understanding Renal Anemia pipeline depth and focus of Indication therapeutics

Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline

Table of Contents

Table of Contents 2

List of Tables 6

List of Figures 7

Introduction 8

Global Markets Direct Report Coverage 8

Renal Anemia Overview 9

Therapeutics Development 10

Pipeline Products for Renal Anemia-Overview 10

Pipeline Products for Renal Anemia-Comparative Analysis 11

Renal Anemia-Therapeutics under Development by Companies 12

Renal Anemia-Pipeline Products Glance 15

Late Stage Products 15

Clinical Stage Products 16

Early Stage Products 17

Renal Anemia-Products under Development by Companies 18

Renal Anemia-Companies Involved in Therapeutics Development 21

3SBio Inc. 21

Acceleron Pharma, Inc. 22

Akebia Therapeutics, Inc. 23

Amgen Inc. 24

Aprogen, Inc. 25

Bayer AG 26


CCM Duopharma Biotech Bhd. 28

Daiichi Sankyo Company, Limited 29

Dong-A Socio Group 30

FibroGen, Inc. 31

GlaxoSmithKline plc 32

Hospira, Inc. 33

Intas Pharmaceuticals Ltd. 34

Japan Tobacco Inc. 35

JCR Pharmaceuticals Co., Ltd. 36

Jiangsu Hansoh Pharmaceutical Co., Ltd. 37

Medgenics Inc. 38

Myungmoon pharmaceutical Co.,Ltd. 39

Panacea Biotec Limited 40

Pieris AG 41

ProMetic Life Sciences Inc. 42

Sandoz International GmbH 43

Zydus Cadila Healthcare Limited 44

Renal Anemia-Therapeutics Assessment 45

Assessment by Monotherapy Products 45

Assessment by Target 46

Assessment by Mechanism of Action 48

Assessment by Route of Administration 50

Assessment by Molecule Type 52

Drug Profiles 54

AKB-6548-Drug Profile 54

Product Description 54

Mechanism of Action 54

R&D Progress 54

daprodustat-Drug Profile 55

Product Description 55

Mechanism of Action 55

R&D Progress 55

darbepoetin alfa-Drug Profile 57

Product Description 57

Mechanism of Action 57

R&D Progress 57

darbepoetin alfa-Drug Profile 58

Product Description 58

Mechanism of Action 58

R&D Progress 58

darbepoetin alfa-Drug Profile 59

Product Description 59

Mechanism of Action 59

R&D Progress 59

darbepoetin alfa-Drug Profile 60

Product Description 60

Mechanism of Action 60

R&D Progress 60

darbepoetin alfa-Drug Profile 61

Product Description 61

Mechanism of Action 61

R&D Progress 61

darbepoetin alfa (recombinant)-Drug Profile 62

Product Description 62

Mechanism of Action 62

R&D Progress 62

DS-1093-Drug Profile 64

Product Description 64

Mechanism of Action 64

R&D Progress 64

EPO-018B-Drug Profile 65

Product Description 65

Mechanism of Action 65

R&D Progress 65

epoetin alfa-Drug Profile 66

Product Description 66

Mechanism of Action 66

R&D Progress 66

epoetin alfa (recombinant)-Drug Profile 67

Product Description 67

Mechanism of Action 67

R&D Progress 67

epoetin zeta-Drug Profile 69

Product Description 69

Mechanism of Action 69

R&D Progress 69

FG-2216-Drug Profile 71

Product Description 71

Mechanism of Action 71

R&D Progress 71

FMX-8-Drug Profile 73

Product Description 73

Mechanism of Action 73

R&D Progress 73

JTZ-951-Drug Profile 74

Product Description 74

Mechanism of Action 74

R&D Progress 74

MDGN-201-Drug Profile 75

Product Description 75

Mechanism of Action 75

R&D Progress 75

MM-P01-01-Drug Profile 76

Product Description 76

Mechanism of Action 76

R&D Progress 76

molidustat-Drug Profile 77

Product Description 77

Mechanism of Action 77

R&D Progress 77

NuPIAO-Drug Profile 79

Product Description 79

Mechanism of Action 79

R&D Progress 79

PBI-1402-Drug Profile 80

Product Description 80

Mechanism of Action 80

R&D Progress 80

PBI-4050-Drug Profile 82

Product Description 82

Mechanism of Action 82

R&D Progress 82

PEG-EPO-Drug Profile 83

Product Description 83

Mechanism of Action 83

R&D Progress 83

Peg-EPO-Drug Profile 84

Product Description 84

Mechanism of Action 84

R&D Progress 84

PRS-080-Drug Profile 85

Product Description 85

Mechanism of Action 85

R&D Progress 85

Recombinant Protein for Renal Anemia-Drug Profile 86

Product Description 86

Mechanism of Action 86

R&D Progress 86

roxadustat-Drug Profile 87

Product Description 87

Mechanism of Action 87

R&D Progress 87

sotatercept-Drug Profile 90

Product Description 90

Mechanism of Action 90

R&D Progress 90

Renal Anemia-Recent Pipeline Updates 93

Renal Anemia-Dormant Projects 110

Renal Anemia-Discontinued Products 111

Renal Anemia-Product Development Milestones 112

Featured News & Press Releases 112

Mar 27, 2015: Hospira Clinical Data Shows Proposed Biosimilar, Epoetin Hospira, Demonstrates Pharmacokinetic And Pharmacodynamic Equivalence Compared To Amgen's Epogen 112

Mar 16, 2015: Akebia Announces Presentation of Results from its Phase 2b Study of AKB-6548 in Non-Dialysis Patients with Anemia at WCN 112

Mar 11, 2015: Bayer to Present Latest Clinical Data On Molidustat 114

Mar 10, 2015: Akebia Announces Completion of Enrollment in Phase 2 Trial of AKB-6548 in Dialysis Patients with Anemia Related to Chronic Kidney Disease 114

Oct 15, 2014: Medgenics Reports Positive Initial Clinical Data From Clinical Study Of MDGN-201 115

Sep 26, 2013: ProMetic's Lead Drug Candidate, PBI-4050, Enters Clinical Program 116

Sep 13, 2013: Approval of Additional Indication of Long-Acting Erythropoiesis-Stimulating Agent NESP for Pediatric Patients with renal anemia in Japan 116

Jul 31, 2013: Astellas and FibroGen Announce the Initiation of a Phase 2 Clinical Study in Japan of ASP1517/FG-4592 for Treatment of Anemia of Chronic Kidney Disease 117

Apr 16, 2013: Amgen To Pay US $24.9m To Resolve False Claims Act Allegations 117

Jan 16, 2013: Amgen Announces Top-Line Results Of Phase III Aranesp RED-HF Trial 118

Appendix 120

Methodology 120

Coverage 120

Secondary Research 120

Primary Research 120

Expert Panel Validation 120

Contact Us 120

Disclaimer 121

List of Tables

Number of Products under Development for Renal Anemia, H1 2015 10

Number of Products under Development for Renal Anemia-Comparative Analysis, H1 2015 11

Number of Products under Development by Companies, H1 2015 13

Number of Products under Development by Companies, H1 2015 (Contd..1) 14

Comparative Analysis by Late Stage Development, H1 2015 15

Comparative Analysis by Clinical Stage Development, H1 2015 16

Comparative Analysis by Early Stage Development, H1 2015 17

Products under Development by Companies, H1 2015 18

Products under Development by Companies, H1 2015 (Contd..1) 19

Products under Development by Companies, H1 2015 (Contd..2) 20

Renal Anemia-Pipeline by 3SBio Inc., H1 2015 21

Renal Anemia-Pipeline by Acceleron Pharma, Inc., H1 2015 22

Renal Anemia-Pipeline by Akebia Therapeutics, Inc., H1 2015 23

Renal Anemia-Pipeline by Amgen Inc., H1 2015 24

Renal Anemia-Pipeline by Aprogen, Inc., H1 2015 25

Renal Anemia-Pipeline by Bayer AG, H1 2015 26

Renal Anemia-Pipeline by BIOCAD, H1 2015 27

Renal Anemia-Pipeline by CCM Duopharma Biotech Bhd., H1 2015 28

Renal Anemia-Pipeline by Daiichi Sankyo Company, Limited, H1 2015 29

Renal Anemia-Pipeline by Dong-A Socio Group, H1 2015 30

Renal Anemia-Pipeline by FibroGen, Inc., H1 2015 31

Renal Anemia-Pipeline by GlaxoSmithKline plc, H1 2015 32

Renal Anemia-Pipeline by Hospira, Inc., H1 2015 33

Renal Anemia-Pipeline by Intas Pharmaceuticals Ltd., H1 2015 34

Renal Anemia-Pipeline by Japan Tobacco Inc., H1 2015 35

Renal Anemia-Pipeline by JCR Pharmaceuticals Co., Ltd., H1 2015 36

Renal Anemia-Pipeline by Jiangsu Hansoh Pharmaceutical Co., Ltd., H1 2015 37

Renal Anemia-Pipeline by Medgenics Inc., H1 2015 38

Renal Anemia-Pipeline by Myungmoon pharmaceutical Co.,Ltd., H1 2015 39

Renal Anemia-Pipeline by Panacea Biotec Limited, H1 2015 40

Renal Anemia-Pipeline by Pieris AG, H1 2015 41

Renal Anemia-Pipeline by ProMetic Life Sciences Inc., H1 2015 42

Renal Anemia-Pipeline by Sandoz International GmbH, H1 2015 43

Renal Anemia-Pipeline by Zydus Cadila Healthcare Limited, H1 2015 44

Assessment by Monotherapy Products, H1 2015 45

Number of Products by Stage and Target, H1 2015 47

Number of Products by Stage and Mechanism of Action, H1 2015 49

Number of Products by Stage and Route of Administration, H1 2015 51

Number of Products by Stage and Molecule Type, H1 2015 53

Renal Anemia Therapeutics-Recent Pipeline Updates, H1 2015 93

Renal Anemia-Dormant Projects, H1 2015 110

Renal Anemia-Discontinued Products, H1 2015 111

List of Figures

Number of Products under Development for Renal Anemia, H1 2015 10

Number of Products under Development for Renal Anemia-Comparative Analysis, H1 2015 11

Number of Products under Development by Companies, H1 2015 12

Comparative Analysis by Late Stage Development, H1 2015 15

Comparative Analysis by Clinical Stage Development, H1 2015 16

Comparative Analysis by Early Stage Products, H1 2015 17

Assessment by Monotherapy Products, H1 2015 45

Number of Products by Top 10 Targets, H1 2015 46

Number of Products by Stage and Top 10 Targets, H1 2015 47

Number of Products by Top 10 Mechanism of Actions, H1 2015 48

Number of Products by Stage and Top 10 Mechanism of Actions, H1 2015 49

Number of Products by Top 10 Routes of Administration, H1 2015 50

Number of Products by Stage and Top 10 Routes of Administration, H1 2015 51

Number of Products by Top 10 Molecule Types, H1 2015 52

Number of Products by Stage and Top 10 Molecule Types, H1 2015 53

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To know more information on Purchase by Section, please send a mail to query [@]

3SBio Inc.

Acceleron Pharma, Inc.

Akebia Therapeutics, Inc.

Amgen Inc.

Aprogen, Inc.

Bayer AG


CCM Duopharma Biotech Bhd.

Daiichi Sankyo Company, Limited

Dong-A Socio Group

FibroGen, Inc.

GlaxoSmithKline plc

Hospira, Inc.

Intas Pharmaceuticals Ltd.

Japan Tobacco Inc.

JCR Pharmaceuticals Co., Ltd.

Jiangsu Hansoh Pharmaceutical Co., Ltd.

Medgenics Inc.

Myungmoon pharmaceutical Co.,Ltd.

Panacea Biotec Limited

Pieris AG

ProMetic Life Sciences Inc.

Sandoz International GmbH

Zydus Cadila Healthcare Limited

Renal Anemia Therapeutic Products under Development, Key Players in Renal Anemia Therapeutics, Renal Anemia Pipeline Overview, Renal Anemia Pipeline, Renal Anemia Pipeline Assessment

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