Rhabdomyosarcoma-Pipeline Review, H2 2015

Rhabdomyosarcoma-Pipeline Review, H2 2015


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Executive Summary

Rhabdomyosarcoma-Pipeline Review, H2 2015

Summary

Global Markets Direct's, 'Rhabdomyosarcoma-Pipeline Review, H2 2015', provides an overview of the Rhabdomyosarcoma's therapeutic pipeline.

This report provides comprehensive information on the therapeutic development for Rhabdomyosarcoma, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Rhabdomyosarcoma and special features on late-stage and discontinued projects.

Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis.

The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.

Scope

The report provides a snapshot of the global therapeutic landscape of Rhabdomyosarcoma

The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities

The report reviews key players involved in the therapeutics development for Rhabdomyosarcoma and enlists all their major and minor projects

The report summarizes all the dormant and discontinued pipeline projects

A review of the Rhabdomyosarcoma products under development by companies and universities/research institutes based on information derived from company and industry-specific sources

Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages

A detailed assessment of monotherapy and combination therapy pipeline projects

Coverage of the Rhabdomyosarcoma pipeline on the basis of target, MoA, route of administration and molecule type

Latest news and deals relating related to pipeline products

Reasons To Buy

Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies

Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage

Develop strategic initiatives by understanding the focus areas of leading companies

Identify and understand important and diverse types of therapeutics under development for Rhabdomyosarcoma

Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline

Devise corrective measures for pipeline projects by understanding Rhabdomyosarcoma pipeline depth and focus of Indication therapeutics

Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline



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Table of Contents

Table of Contents 2

List of Tables 5

List of Figures 5

Introduction 6

Global Markets Direct Report Coverage 6

Rhabdomyosarcoma Overview 7

Therapeutics Development 8

Pipeline Products for Rhabdomyosarcoma-Overview 8

Pipeline Products for Rhabdomyosarcoma-Comparative Analysis 9

Rhabdomyosarcoma-Therapeutics under Development by Companies 10

Rhabdomyosarcoma-Therapeutics under Investigation by Universities/Institutes 11

Rhabdomyosarcoma-Pipeline Products Glance 12

Clinical Stage Products 12

Early Stage Products 13

Rhabdomyosarcoma-Products under Development by Companies 14

Rhabdomyosarcoma-Products under Investigation by Universities/Institutes 15

Rhabdomyosarcoma-Companies Involved in Therapeutics Development 16

Bellicum Pharmaceuticals, Inc. 16

Boehringer Ingelheim GmbH 17

Celgene Corporation 18

EpiZyme, Inc. 19

Merrimack Pharmaceuticals, Inc. 20

Morphotek, Inc. 21

Novartis AG 22

Noxxon Pharma AG 23

Shionogi & Co., Ltd. 24

Rhabdomyosarcoma-Therapeutics Assessment 25

Assessment by Monotherapy Products 25

Assessment by Target 26

Assessment by Mechanism of Action 29

Assessment by Route of Administration 31

Assessment by Molecule Type 33

Drug Profiles 35

afatinib dimaleate-Drug Profile 35

Product Description 35

Mechanism of Action 35

R&D Progress 35

Cell Therapy for GD2 Expressing Solid Tumors-Drug Profile 39

Product Description 39

Mechanism of Action 39

R&D Progress 39

celyvir-Drug Profile 41

Product Description 41

Mechanism of Action 41

R&D Progress 41

Dendritic Cell Therapy to Target MAGE-A1, MAGE-A3 and NY-ESO-1 for Oncology-Drug Profile 43

Product Description 43

Mechanism of Action 43

R&D Progress 43

everolimus-Drug Profile 44

Product Description 44

Mechanism of Action 44

R&D Progress 44

irinotecan sucrosofate-Drug Profile 50

Product Description 50

Mechanism of Action 50

R&D Progress 50

NOXS-93-Drug Profile 53

Product Description 53

Mechanism of Action 53

R&D Progress 53

ontuxizumab-Drug Profile 54

Product Description 54

Mechanism of Action 54

R&D Progress 54

paclitaxel albumin bound-Drug Profile 56

Product Description 56

Mechanism of Action 56

R&D Progress 56

pazopanib hydrochloride-Drug Profile 60

Product Description 60

Mechanism of Action 60

R&D Progress 60

S-588410-Drug Profile 66

Product Description 66

Mechanism of Action 66

R&D Progress 66

tazemetostat-Drug Profile 67

Product Description 67

Mechanism of Action 67

R&D Progress 67

Rhabdomyosarcoma-Recent Pipeline Updates 69

Rhabdomyosarcoma-Dormant Projects 100

Rhabdomyosarcoma-Discontinued Products 101

Appendix 102

Methodology 102

Coverage 102

Secondary Research 102

Primary Research 102

Expert Panel Validation 102

Contact Us 102

Disclaimer 103

List of Tables

Number of Products under Development for Rhabdomyosarcoma, H2 2015 8

Number of Products under Development for Rhabdomyosarcoma-Comparative Analysis, H2 2015 9

Number of Products under Development by Companies, H2 2015 10

Number of Products under Investigation by Universities/Institutes, H2 2015 11

Comparative Analysis by Clinical Stage Development, H2 2015 12

Comparative Analysis by Early Stage Development, H2 2015 13

Products under Development by Companies, H2 2015 14

Products under Investigation by Universities/Institutes, H2 2015 15

Rhabdomyosarcoma-Pipeline by Bellicum Pharmaceuticals, Inc., H2 2015 16

Rhabdomyosarcoma-Pipeline by Boehringer Ingelheim GmbH, H2 2015 17

Rhabdomyosarcoma-Pipeline by Celgene Corporation, H2 2015 18

Rhabdomyosarcoma-Pipeline by EpiZyme, Inc., H2 2015 19

Rhabdomyosarcoma-Pipeline by Merrimack Pharmaceuticals, Inc., H2 2015 20

Rhabdomyosarcoma-Pipeline by Morphotek, Inc., H2 2015 21

Rhabdomyosarcoma-Pipeline by Novartis AG, H2 2015 22

Rhabdomyosarcoma-Pipeline by Noxxon Pharma AG, H2 2015 23

Rhabdomyosarcoma-Pipeline by Shionogi & Co., Ltd., H2 2015 24

Assessment by Monotherapy Products, H2 2015 25

Number of Products by Stage and Target, H2 2015 27

Number of Products by Stage and Mechanism of Action, H2 2015 30

Number of Products by Stage and Route of Administration, H2 2015 32

Number of Products by Stage and Molecule Type, H2 2015 34

Rhabdomyosarcoma Therapeutics-Recent Pipeline Updates, H2 2015 69

Rhabdomyosarcoma-Dormant Projects, H2 2015 100

Rhabdomyosarcoma-Discontinued Products, H2 2015 101

List of Figures

Number of Products under Development for Rhabdomyosarcoma, H2 2015 8

Number of Products under Development for Rhabdomyosarcoma-Comparative Analysis, H2 2015 9

Number of Products under Development by Companies, H2 2015 10

Comparative Analysis by Clinical Stage Development, H2 2015 12

Comparative Analysis by Early Stage Products, H2 2015 13

Assessment by Monotherapy Products, H2 2015 25

Number of Products by Top 10 Targets, H2 2015 26

Number of Products by Stage and Top 10 Targets, H2 2015 26

Number of Products by Top 10 Mechanism of Actions, H2 2015 29

Number of Products by Stage and Top 10 Mechanism of Actions, H2 2015 29

Number of Products by Top 10 Routes of Administration, H2 2015 31

Number of Products by Stage and Top 10 Routes of Administration, H2 2015 31

Number of Products by Top 10 Molecule Types, H2 2015 33

Number of Products by Stage and Top 10 Molecule Types, H2 2015 33

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Bellicum Pharmaceuticals, Inc.

Boehringer Ingelheim GmbH

Celgene Corporation

EpiZyme, Inc.

Merrimack Pharmaceuticals, Inc.

Morphotek, Inc.

Novartis AG

Noxxon Pharma AG

Shionogi & Co., Ltd.

Rhabdomyosarcoma Therapeutic Products under Development, Key Players in Rhabdomyosarcoma Therapeutics, Rhabdomyosarcoma Pipeline Overview, Rhabdomyosarcoma Pipeline, Rhabdomyosarcoma Pipeline Assessment

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