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Thromboembolism-Pipeline Review, H1 2015

Thromboembolism-Pipeline Review, H1 2015


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Executive Summary

Thromboembolism-Pipeline Review, H1 2015

Summary

Global Markets Direct's, 'Thromboembolism-Pipeline Review, H1 2015', provides an overview of the Thromboembolism's therapeutic pipeline.

This report provides comprehensive information on the therapeutic development for Thromboembolism, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Thromboembolism and special features on late-stage and discontinued projects.

Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis.

The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.

Scope

The report provides a snapshot of the global therapeutic landscape of Thromboembolism

The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities

The report reviews key players involved in the therapeutics development for Thromboembolism and enlists all their major and minor projects

The report summarizes all the dormant and discontinued pipeline projects

A review of the Thromboembolism products under development by companies and universities/research institutes based on information derived from company and industry-specific sources

Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages

A detailed assessment of monotherapy and combination therapy pipeline projects

Coverage of the Thromboembolism pipeline on the basis of target, MoA, route of administration and molecule type

Latest news and deals relating related to pipeline products

Reasons To Buy

Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies

Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage

Develop strategic initiatives by understanding the focus areas of leading companies

Identify and understand important and diverse types of therapeutics under development for Thromboembolism

Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline

Devise corrective measures for pipeline projects by understanding Thromboembolism pipeline depth and focus of Indication therapeutics

Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline

Table of Contents

Table of Contents 2

List of Tables 5

List of Figures 6

Introduction 7

Global Markets Direct Report Coverage 7

Thromboembolism Overview 8

Therapeutics Development 9

Pipeline Products for Thromboembolism-Overview 9

Pipeline Products for Thromboembolism-Comparative Analysis 10

Thromboembolism-Therapeutics under Development by Companies 11

Thromboembolism-Therapeutics under Investigation by Universities/Institutes 13

Thromboembolism-Pipeline Products Glance 14

Late Stage Products 14

Clinical Stage Products 15

Early Stage Products 16

Thromboembolism-Products under Development by Companies 17

Thromboembolism-Products under Investigation by Universities/Institutes 18

Thromboembolism-Companies Involved in Therapeutics Development 19

Bayer AG 19

Cereno Scientific AB 20

CSL Limited 21

Daiichi Sankyo Company, Limited 22

Gamma Therapeutics, Inc. 23

Green Cross Corporation 24

Isis Pharmaceuticals, Inc. 25

Portola Pharmaceuticals, Inc. 26

Regado Biosciences, Inc. 27

Sanofi 28

Thromboembolism-Therapeutics Assessment 29

Assessment by Monotherapy Products 29

Assessment by Target 30

Assessment by Mechanism of Action 32

Assessment by Route of Administration 34

Assessment by Molecule Type 36

Drug Profiles 38

betrixaban-Drug Profile 38

Product Description 38

Mechanism of Action 38

R&D Progress 38

C-3-Drug Profile 40

Product Description 40

Mechanism of Action 40

R&D Progress 40

CSL-3F7-Drug Profile 41

Product Description 41

Mechanism of Action 41

R&D Progress 41

edoxaban tosylate-Drug Profile 42

Product Description 42

Mechanism of Action 42

R&D Progress 42

Gammarin-Drug Profile 44

Product Description 44

Mechanism of Action 44

R&D Progress 44

GCC-2107-Drug Profile 45

Product Description 45

Mechanism of Action 45

R&D Progress 45

ISIS-FXIRx-Drug Profile 46

Product Description 46

Mechanism of Action 46

R&D Progress 46

Lysimab-Drug Profile 47

Product Description 47

Mechanism of Action 47

R&D Progress 47

Protein for Thromboembolism and Blood Coagulation-Drug Profile 48

Product Description 48

Mechanism of Action 48

R&D Progress 48

REG-2-Drug Profile 50

Product Description 50

Mechanism of Action 50

R&D Progress 50

rivaroxaban-Drug Profile 52

Product Description 52

Mechanism of Action 52

R&D Progress 52

semuloparin-Drug Profile 57

Product Description 57

Mechanism of Action 57

R&D Progress 57

Small Molecules to Inhibit HDAC for Thromboembolism-Drug Profile 58

Product Description 58

Mechanism of Action 58

R&D Progress 58

TAP-ANV-Drug Profile 59

Product Description 59

Mechanism of Action 59

R&D Progress 59

YG-001-Drug Profile 60

Product Description 60

Mechanism of Action 60

R&D Progress 60

Thromboembolism-Recent Pipeline Updates 61

Thromboembolism-Dormant Projects 78

Thromboembolism-Discontinued Products 79

Thromboembolism-Product Development Milestones 80

Featured News & Press Releases 80

Dec 08, 2014: Daiichi Sankyo Launches New Formulation of LIXIANA 60 mg Tablets (edoxaban) in Japan 80

Dec 07, 2014: Isis Pharmaceuticals Reports Positive Phase 2 Data for ISIS-FXI Rx for the Prevention of Venous Thrombosis in Patients Undergoing Total Knee Replacement Surgery 80

Nov 18, 2014: Isis Pharmaceuticals To Host Webcast To Discuss ISIS-FXI Rx Data Presented At The ASH Annual Meeting 82

Oct 28, 2014: U.S. FDA Cardiovascular and Renal Drugs Advisory Committee Makes Recommendation on Daiichi Sankyo's Once-Daily SAVAYSA for the Reduction in Risk of Stroke and Systemic Embolic Events in Patients with Non-Valvular Atrial Fibrillation 82

Sep 26, 2014: Daiichi Sankyo Receives Approval for Additional Indications of LIXIANA (edoxaban) in Japan 83

Aug 30, 2014: Secondary Analysis of AMPLIFY-EXT Examining Predictors of Hospitalization Presented at ESC Congress: Eliquis (apixaban) Significantly Reduced the Risk of All-Cause Hospitalization Versus Placebo in Patients with Venous Thromboembolism (VTE) 83

Jun 23, 2014: Regado Biosciences REG2 Demonstrates Dose and Concentration Dependent Suppression of Thrombin Generation 84

May 28, 2014: Xarelto from Bayer Submitted in Japan for the Treatment of Deep Vein Thrombosis and Pulmonary Embolism as well as for the Prevention of Recurrent Venous Thromboembolism 85

May 22, 2014: Isis Pharmaceuticals Reports Positive Phase 2 Data for ISIS-FXI Rx in the Prevention of Venous Thrombosis in Patients Undergoing Total Knee Replacement Surgery 86

May 12, 2014: Portola Pharmaceuticals Begins Enrollment in Phase 3 Study of FDA-Designated Breakthrough Therapy Andexanet Alfa and Factor Xa Inhibitor XARELTO 87

Appendix 89

Methodology 89

Coverage 89

Secondary Research 89

Primary Research 89

Expert Panel Validation 89

Contact Us 90

Disclaimer 90

List of Tables

Number of Products under Development for Thromboembolism, H1 2015 9

Number of Products under Development for Thromboembolism-Comparative Analysis, H1 2015 10

Number of Products under Development by Companies, H1 2015 12

Number of Products under Investigation by Universities/Institutes, H1 2015 13

Comparative Analysis by Late Stage Development, H1 2015 14

Comparative Analysis by Clinical Stage Development, H1 2015 15

Comparative Analysis by Early Stage Development, H1 2015 16

Products under Development by Companies, H1 2015 17

Products under Investigation by Universities/Institutes, H1 2015 18

Thromboembolism-Pipeline by Bayer AG, H1 2015 19

Thromboembolism-Pipeline by Cereno Scientific AB, H1 2015 20

Thromboembolism-Pipeline by CSL Limited, H1 2015 21

Thromboembolism-Pipeline by Daiichi Sankyo Company, Limited, H1 2015 22

Thromboembolism-Pipeline by Gamma Therapeutics, Inc., H1 2015 23

Thromboembolism-Pipeline by Green Cross Corporation, H1 2015 24

Thromboembolism-Pipeline by Isis Pharmaceuticals, Inc., H1 2015 25

Thromboembolism-Pipeline by Portola Pharmaceuticals, Inc., H1 2015 26

Thromboembolism-Pipeline by Regado Biosciences, Inc., H1 2015 27

Thromboembolism-Pipeline by Sanofi, H1 2015 28

Assessment by Monotherapy Products, H1 2015 29

Number of Products by Stage and Target, H1 2015 31

Number of Products by Stage and Mechanism of Action, H1 2015 33

Number of Products by Stage and Route of Administration, H1 2015 35

Number of Products by Stage and Molecule Type, H1 2015 37

Thromboembolism Therapeutics-Recent Pipeline Updates, H1 2015 61

Thromboembolism-Dormant Projects, H1 2015 78

Thromboembolism-Discontinued Products, H1 2015 79

List of Figures

Number of Products under Development for Thromboembolism, H1 2015 9

Number of Products under Development for Thromboembolism-Comparative Analysis, H1 2015 10

Number of Products under Development by Companies, H1 2015 11

Comparative Analysis by Late Stage Development, H1 2015 14

Comparative Analysis by Clinical Stage Development, H1 2015 15

Comparative Analysis by Early Stage Products, H1 2015 16

Assessment by Monotherapy Products, H1 2015 29

Number of Products by Top 10 Targets, H1 2015 30

Number of Products by Stage and Top 10 Targets, H1 2015 30

Number of Products by Top 10 Mechanism of Actions, H1 2015 32

Number of Products by Stage and Top 10 Mechanism of Actions, H1 2015 33

Number of Products by Top 10 Routes of Administration, H1 2015 34

Number of Products by Stage and Top 10 Routes of Administration, H1 2015 35

Number of Products by Top 10 Molecule Types, H1 2015 36

Number of Products by Stage and Top 10 Molecule Types, H1 2015 37

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Bayer AG

Cereno Scientific AB

CSL Limited

Daiichi Sankyo Company, Limited

Gamma Therapeutics, Inc.

Green Cross Corporation

Isis Pharmaceuticals, Inc.

Portola Pharmaceuticals, Inc.

Regado Biosciences, Inc.

Sanofi

Thromboembolism Therapeutic Products under Development, Key Players in Thromboembolism Therapeutics, Thromboembolism Pipeline Overview, Thromboembolism Pipeline, Thromboembolism Pipeline Assessment


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