Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2) - Pipeline Review, H2 2018

Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2) - Pipeline Review, H2 2018


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Executive Summary

Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2)-Pipeline Review, H2 2018

Summary

Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2) pipeline Target constitutes close to 8 molecules. Out of which approximately 6 molecules are developed by companies and remaining by the universities/institutes. The latest report Type 2 Angiotensin II Receptor-Pipeline Review, H2 2018, outlays comprehensive information on the Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.

Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2)-Angiotensin II receptor type 2 (AT2 receptor) is a protein encoded by the AGTR2 gene. AT2 receptor is highly expressed in the developing foetus, but its expression is very low in the cardiovascular system of the normal adult. Expression of the AT2 receptor can be modulated by pathological states associated with tissue remodeling or inflammation such as hypertension, atherosclerosis, and myocardial infarction. AT2 receptor plays an important role in vasodilatory role, and enhanced as a countervailing mechanism in cardiac hypertrophy, and in presence of vascular injury in hypertension and atherosclerosis. The molecules developed by companies in Phase III, Phase II, Preclinical and Discovery stages are 1, 2, 2 and 1 respectively. Similarly, the universities portfolio in Preclinical stages comprises 2 molecules, respectively.

Report covers products from therapy areas Cardiovascular, Central Nervous System, Dermatology, Genito Urinary System And Sex Hormones, Metabolic Disorders, Oncology, Gastrointestinal, Immunology, Musculoskeletal Disorders, Respiratory and Women's Health which include indications Acute Ischemic Stroke, Atherosclerosis, Cardiomyopathy, Chronic Kidney Disease (Chronic Renal Failure), Congestive Heart Failure (Heart Failure), Dementia Associated With Alzheimer's Disease, Dermatitis (Eczema), Diabetic Nephropathy, Diabetic Neuropathic Pain, Fibrosis, Hyperlipidemia, Hypertension, Idiopathic Pulmonary Fibrosis, Inflammatory Pain, Kidney Fibrosis, Leiomyosarcoma, Liver Fibrosis, Multiple Sclerosis, Myocardial Fibrosis, Myocardial Infarction, Neuromyelitis Optica (Devic's Syndrome), Obesity, Peripheral Neuropathic Pain, Polycystic Ovarian Syndrome, Postherpetic Neuralgia, Prostate Cancer, Psoriasis, Pulmonary Arterial Hypertension, Rheumatoid Arthritis, Skin Inflammation, Spinal Cord Injury, Systemic Sclerosis (Scleroderma), Type 2 Diabetes and Wounds.

Furthermore, this report also reviews key players involved in Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2) targeted therapeutics development with respective active and dormant or discontinued projects. Driven by data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources.

Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope

- The report provides a snapshot of the global therapeutic landscape for Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2)

- The report reviews Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources

- The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages

- The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities

- The report reviews key players involved in Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2) targeted therapeutics and enlists all their major and minor projects

- The report assesses Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type

- The report summarizes all the dormant and discontinued pipeline projects

- The report reviews latest news and deals related to Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2) targeted therapeutics

Reasons to buy

- Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies

- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage

- Identify and understand the targeted therapy areas and indications for Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2)

- Identify the use of drugs for target identification and drug repurposing

- Identify potential new clients or partners in the target demographic

- Develop strategic initiatives by understanding the focus areas of leading companies

- Plan mergers and acquisitions effectively by identifying key players and it's most promising pipeline therapeutics

- Devise corrective measures for pipeline projects by understanding Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2) development landscape

- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope



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Table of Contents

List of Tables

List of Figures

Introduction

Global Markets Direct Report Coverage

Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2)-Overview

Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2)-Therapeutics Development

Products under Development by Stage of Development

Products under Development by Therapy Area

Products under Development by Indication

Products under Development by Companies

Products under Development by Universities/Institutes

Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2)-Therapeutics Assessment

Assessment by Mechanism of Action

Assessment by Route of Administration

Assessment by Molecule Type

Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2)-Companies Involved in Therapeutics Development

CJ HealthCare Corp

MorphoSys AG

Novartis AG

Vicore Pharma AB

Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2)-Drug Profiles

(amlodipine besylate + valsartan) + atorvastatin calcium-Drug Profile

Product Description

Mechanism Of Action

R&D Progress

C-21-Drug Profile

Product Description

Mechanism Of Action

R&D Progress

MOR-107-Drug Profile

Product Description

Mechanism Of Action

R&D Progress

NP-6A-Drug Profile

Product Description

Mechanism Of Action

R&D Progress

olodanrigan-Drug Profile

Product Description

Mechanism Of Action

R&D Progress

Small Molecule to Antagonize AGTR2 for Skin Inflammation and Inflammatory Pain-Drug Profile

Product Description

Mechanism Of Action

R&D Progress

Small Molecules to Agonize AGTR2 for Fibrosis-Drug Profile

Product Description

Mechanism Of Action

R&D Progress

Synthetic Peptides to Agonize AGTR2 for Kidney Fibrosis, Liver Fibrosis and Myocardial Fibrosis-Drug Profile

Product Description

Mechanism Of Action

R&D Progress

Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2)-Dormant Products

Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2)-Discontinued Products

Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2)-Product Development Milestones

Featured News & Press Releases

Sep 10, 2018: Vicore Pharma expands VP01 (C21) clinical program to enable functional read out

Jul 05, 2018: Non-opioid drug relieves pain in mice, targets immune cells

Apr 18, 2018: Vicore Pharma receives approval to start Phase IIa study in IPF

Mar 21, 2018: Frontiers in Physiology publish data with C21 on pulmonary fibrosis

Jan 26, 2018: Highlights from new publications on C21 and the AT2 receptor

Dec 22, 2017: Vicore Pharma has submitted an application to start a phase II study for Idiopathic Pulmonary Fibrosis

Oct 09, 2017: Clinical Potential of C21 Highlighted in Review Publications

Oct 02, 2017: Phase I extension study demonstrates beneficial effects on lipid metabolism with C21

Aug 17, 2017: Results from Extension Study with C21 Show Safety, Tolerability and Indicate Effects on lipid Metabolism

May 19, 2017: MorphoSys Announces First Results from Phase 1 Study with Lanthipeptide MOR107 in Healthy Volunteers

Mar 08, 2017: C21 has a strong impact on several markers in an in vitro study for pulmonary fibrosis

Mar 03, 2017: New positive study results on diabetic nephropathy with Vicore Pharma's candidate drug C21

Feb 21, 2017: MorphoSys's Subsidiary Lanthio Pharma Initiates First-in-Human Clinical Study with Lanthipeptide MOR107

Feb 15, 2017: Vicore Pharma extends research portfolio with new drug molecules

Sep 19, 2016: Lanthio Pharma Expands Management Team: Axel Mescheder M.D. Appointed Chief Medical Officer (CMO) of MorphoSys's Dutch Lanthipeptide Subsidiary

Appendix

Methodology

Coverage

Secondary Research

Primary Research

Expert Panel Validation

Contact Us

Disclaimer

List of Figures

Number of Products under Development by Stage of Development, H2 2018

Number of Products under Development by Therapy Areas, H2 2018

Number of Products under Development by Top 10 Indications, H2 2018

Number of Products by Mechanism of Actions, H2 2018

Number of Products by Stage and Mechanism of Actions, H2 2018

Number of Products by Routes of Administration, H2 2018

Number of Products by Stage and Routes of Administration, H2 2018

Number of Products by Molecule Types, H2 2018

Number of Products by Stage and Molecule Types, H2 2018

List of Tables

Number of Products under Development by Stage of Development, H2 2018

Number of Products under Development by Therapy Areas, H2 2018

Number of Products under Development by Indications, H2 2018

Number of Products under Development by Indications, H2 2018 (Contd..1), H2 2018

Number of Products under Development by Companies, H2 2018

Products under Development by Companies, H2 2018

Products under Development by Companies, H2 2018 (Contd..1), H2 2018

Number of Products under Investigation by Universities/Institutes, H2 2018

Products under Investigation by Universities/Institutes, H2 2018

Number of Products by Stage and Mechanism of Actions, H2 2018

Number of Products by Stage and Route of Administration, H2 2018

Number of Products by Stage and Molecule Type, H2 2018

Pipeline by CJ HealthCare Corp, H2 2018

Pipeline by MorphoSys AG, H2 2018

Pipeline by Novartis AG, H2 2018

Pipeline by Vicore Pharma AB, H2 2018

Dormant Projects, H2 2018

Discontinued Products, H2 2018

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CJ HealthCare Corp

MorphoSys AG

Novartis AG

Vicore Pharma AB

Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2) Therapeutic Products under Development, Key Players in Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2) Therapeutics, Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2) Pipeline Overview, Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2) Pipeline, Type 2 Angiotensin II Receptor (Angiotensin II Type 2 Receptor or AGTR2) Pipeline Assessment

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