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Venous (Vein) Thrombosis-Pipeline Review, H1 2015

Venous (Vein) Thrombosis-Pipeline Review, H1 2015


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Executive Summary

Venous (Vein) Thrombosis-Pipeline Review, H1 2015

Summary

Global Markets Direct's, 'Venous (Vein) Thrombosis-Pipeline Review, H1 2015', provides an overview of the Venous (Vein) Thrombosis's therapeutic pipeline.

This report provides comprehensive information on the therapeutic development for Venous (Vein) Thrombosis, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Venous (Vein) Thrombosis and special features on late-stage and discontinued projects.

Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis.

The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.

Scope

The report provides a snapshot of the global therapeutic landscape of Venous (Vein) Thrombosis

The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities

The report reviews key players involved in the therapeutics development for Venous (Vein) Thrombosis and enlists all their major and minor projects

The report summarizes all the dormant and discontinued pipeline projects

A review of the Venous (Vein) Thrombosis products under development by companies and universities/research institutes based on information derived from company and industry-specific sources

Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages

A detailed assessment of monotherapy and combination therapy pipeline projects

Coverage of the Venous (Vein) Thrombosis pipeline on the basis of target, MoA, route of administration and molecule type

Latest news and deals relating related to pipeline products

Reasons To Buy

Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies

Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage

Develop strategic initiatives by understanding the focus areas of leading companies

Identify and understand important and diverse types of therapeutics under development for Venous (Vein) Thrombosis

Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline

Devise corrective measures for pipeline projects by understanding Venous (Vein) Thrombosis pipeline depth and focus of Indication therapeutics

Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline

Table of Contents

Table of Contents 2

List of Tables 5

List of Figures 6

Introduction 7

Global Markets Direct Report Coverage 7

Venous (Vein) Thrombosis Overview 8

Therapeutics Development 9

Pipeline Products for Venous (Vein) Thrombosis-Overview 9

Pipeline Products for Venous (Vein) Thrombosis-Comparative Analysis 10

Venous (Vein) Thrombosis-Therapeutics under Development by Companies 11

Venous (Vein) Thrombosis-Therapeutics under Investigation by Universities/Institutes 12

Venous (Vein) Thrombosis-Pipeline Products Glance 13

Late Stage Products 13

Clinical Stage Products 14

Early Stage Products 15

Venous (Vein) Thrombosis-Products under Development by Companies 16

Venous (Vein) Thrombosis-Products under Investigation by Universities/Institutes 17

Venous (Vein) Thrombosis-Companies Involved in Therapeutics Development 18

Astellas Pharma Inc. 18

Bayer AG 19

Bristol-Myers Squibb Company 20

Eisai Co., Ltd. 21

F. Hoffmann-La Roche Ltd. 22

Generex Biotechnology Corporation 23

Merrion Pharmaceuticals Plc 24

Regado Biosciences, Inc. 25

Venous (Vein) Thrombosis-Therapeutics Assessment 26

Assessment by Monotherapy Products 26

Assessment by Target 27

Assessment by Mechanism of Action 29

Assessment by Route of Administration 31

Assessment by Molecule Type 33

Drug Profiles 35

AB-012-Drug Profile 35

Product Description 35

Mechanism of Action 35

R&D Progress 35

apixaban-Drug Profile 37

Product Description 37

Mechanism of Action 37

R&D Progress 37

AS-1468240-Drug Profile 39

Product Description 39

Mechanism of Action 39

R&D Progress 39

BAY-1213790-Drug Profile 40

Product Description 40

Mechanism of Action 40

R&D Progress 40

BMS-593214-Drug Profile 41

Product Description 41

Mechanism of Action 41

R&D Progress 41

E-5539-Drug Profile 42

Product Description 42

Mechanism of Action 42

R&D Progress 42

enoxaparin sodium-Drug Profile 43

Product Description 43

Mechanism of Action 43

R&D Progress 43

ER-410660-Drug Profile 44

Product Description 44

Mechanism of Action 44

R&D Progress 44

fondaparinux sodium-Drug Profile 45

Product Description 45

Mechanism of Action 45

R&D Progress 45

Ichorcumab-Drug Profile 46

Product Description 46

Mechanism of Action 46

R&D Progress 46

NPB-06-Drug Profile 47

Product Description 47

Mechanism of Action 47

R&D Progress 47

REG-2-Drug Profile 48

Product Description 48

Mechanism of Action 48

R&D Progress 48

rivaroxaban-Drug Profile 50

Product Description 50

Mechanism of Action 50

R&D Progress 50

RNAi Oligonucleotide for DVT-Drug Profile 55

Product Description 55

Mechanism of Action 55

R&D Progress 55

Small Molecules for Hematological Disorders and Cancer-Drug Profile 56

Product Description 56

Mechanism of Action 56

R&D Progress 56

TRX-1-Drug Profile 57

Product Description 57

Mechanism of Action 57

R&D Progress 57

Venous (Vein) Thrombosis-Recent Pipeline Updates 58

Venous (Vein) Thrombosis-Dormant Projects 76

Venous (Vein) Thrombosis-Discontinued Products 77

Venous (Vein) Thrombosis-Product Development Milestones 78

Featured News & Press Releases 78

Apr 07, 2015: Xarelto Litigation Update: Legal-Bay Lawsuit Settlement Funding Reports Issuance of New Court Documents 78

Mar 30, 2015: New Study Shows Reduced Hospital Admissions and Costs for Deep Vein Thrombosis Patients Treated with XARELTO Compared to Traditional Therapy, With No Difference in Subsequent Hospital Visits 78

Mar 02, 2015: Findings to be Presented at Annual Scientific Session of the American College of Cardiology About an Additional Potential Reversal Strategy for and Real-World Safety Performance of XARELTO 80

Nov 26, 2014: ELIQUIS approved for treatment of venous thromboembolic events (Deep Vein Thrombosis [DVT], Pulmonary Embolism [PE]) and prevention of recurrent DVT and PE 81

Aug 22, 2014: U.S. FDA Approves Eliquis for the Treatment of Deep Vein Thrombosis and Pulmonary Embolism, and for the Reduction in the Risk of Recurrent DVT and PE Following Initial Therapy 82

Jul 29, 2014: European Commission Approves Eliquis (apixaban) for the Treatment of Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE), and Prevention of Recurrent DVT and PE 83

Jun 27, 2014: Eliquis (apixaban) Receives CHMP Positive Opinion for the Treatment of Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE), and Prevention of Recurrent DVT and PE 85

Mar 14, 2014: U.S. FDA Approves Eliquis (apixaban) To Reduce The Risk Of Blood Clots Following Hip Or Knee Replacement Surgery 86

Jan 07, 2014: TeaRx announces initiation of Phase II clinical trial of its TeaRx, an oral Factor Xa inhibitor 87

Dec 19, 2013: FDA Accepts For Review ELIQUIS Supplemental New Drug Application For The Treatment Of Deep Vein Thrombosis And Pulmonary Embolism, And For The Reduction In The Risk Of Recurrent DVT And PE 87

Appendix 89

Methodology 89

Coverage 89

Secondary Research 89

Primary Research 89

Expert Panel Validation 89

Contact Us 89

Disclaimer 90

List of Tables

Number of Products under Development for Venous (Vein) Thrombosis, H1 2015 9

Number of Products under Development for Venous (Vein) Thrombosis-Comparative Analysis, H1 2015 10

Number of Products under Development by Companies, H1 2015 11

Number of Products under Investigation by Universities/Institutes, H1 2015 12

Comparative Analysis by Late Stage Development, H1 2015 13

Comparative Analysis by Clinical Stage Development, H1 2015 14

Comparative Analysis by Early Stage Development, H1 2015 15

Products under Development by Companies, H1 2015 16

Products under Investigation by Universities/Institutes, H1 2015 17

Venous (Vein) Thrombosis-Pipeline by Astellas Pharma Inc., H1 2015 18

Venous (Vein) Thrombosis-Pipeline by Bayer AG, H1 2015 19

Venous (Vein) Thrombosis-Pipeline by Bristol-Myers Squibb Company, H1 2015 20

Venous (Vein) Thrombosis-Pipeline by Eisai Co., Ltd., H1 2015 21

Venous (Vein) Thrombosis-Pipeline by F. Hoffmann-La Roche Ltd., H1 2015 22

Venous (Vein) Thrombosis-Pipeline by Generex Biotechnology Corporation, H1 2015 23

Venous (Vein) Thrombosis-Pipeline by Merrion Pharmaceuticals Plc, H1 2015 24

Venous (Vein) Thrombosis-Pipeline by Regado Biosciences, Inc., H1 2015 25

Assessment by Monotherapy Products, H1 2015 26

Number of Products by Stage and Target, H1 2015 28

Number of Products by Stage and Mechanism of Action, H1 2015 30

Number of Products by Stage and Route of Administration, H1 2015 32

Number of Products by Stage and Molecule Type, H1 2015 34

Venous (Vein) Thrombosis Therapeutics-Recent Pipeline Updates, H1 2015 58

Venous (Vein) Thrombosis-Dormant Projects, H1 2015 76

Venous (Vein) Thrombosis-Discontinued Products, H1 2015 77

List of Figures

Number of Products under Development for Venous (Vein) Thrombosis, H1 2015 9

Number of Products under Development for Venous (Vein) Thrombosis-Comparative Analysis, H1 2015 10

Number of Products under Development by Companies, H1 2015 11

Comparative Analysis by Late Stage Development, H1 2015 13

Comparative Analysis by Clinical Stage Development, H1 2015 14

Comparative Analysis by Early Stage Products, H1 2015 15

Assessment by Monotherapy Products, H1 2015 26

Number of Products by Top 10 Targets, H1 2015 27

Number of Products by Stage and Top 10 Targets, H1 2015 28

Number of Products by Top 10 Mechanism of Actions, H1 2015 29

Number of Products by Stage and Top 10 Mechanism of Actions, H1 2015 30

Number of Products by Top 10 Routes of Administration, H1 2015 31

Number of Products by Stage and Top 10 Routes of Administration, H1 2015 32

Number of Products by Top 10 Molecule Types, H1 2015 33

Number of Products by Stage and Top 10 Molecule Types, H1 2015 34

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Astellas Pharma Inc.

Bayer AG

Bristol-Myers Squibb Company

Eisai Co., Ltd.

F. Hoffmann-La Roche Ltd.

Generex Biotechnology Corporation

Merrion Pharmaceuticals Plc

Regado Biosciences, Inc.

Venous (Vein) Thrombosis Therapeutic Products under Development, Key Players in Venous (Vein) Thrombosis Therapeutics, Venous (Vein) Thrombosis Pipeline Overview, Venous (Vein) Thrombosis Pipeline, Venous (Vein) Thrombosis Pipeline Assessment


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