Challenges in Immuno-oncology (I-O): Future Use, Trial Design and Combination Strategies

Challenges in Immuno-oncology (I-O): Future Use, Trial Design and Combination Strategies


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  • Pages: 60
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Executive Summary

Challenges in Immuno-oncology (I-O): Future Use, Trial Design and Combination Strategies

 

Summary

 

Immuno-oncology (I-O) is the treatment of cancer with immunotherapy, by using therapies to stimulate or suppress the body's own immune system to fight cancer. Several distinct modalities of immunotherapy exist, including cytokines, vaccines, viruses, adoptive cell transfer, and checkpoint blockade using monoclonal antibodies.

 

This report provides an assessment of the current status and future challenges of immuno-oncology across many indications. Overall, GlobalData expects innovative trial design and new combination drug approvals to drive immuno-oncology market growth.

 

Scope

 

This report combines primary research with a cross-specialty I-O KOL panel with in-house analyst expertise to provide an assessment of the marketplace. Components of the slide deck include -

- Primary research with 20 US- and EU-based KOLs, from eight cancer specialties - breast, gastrointestinal, genitourinary, head & neck, lung, melanoma, sarcoma and hematology

- Charts summarizing KOL's opinions and identifying response patterns

- Call-outs of key information and details

- KOL quotes

- Insight from GlobalData's specialist oncology analysts

 

Reasons to buy

 

- Develop and design your in-licensing and out-licensing strategies through a review of the potential of novel agents across tumor specialties by mechanism of action.

- Develop business strategies by understanding the trends shaping and driving the global immuno-oncology market.

- Drive revenues by understanding the key trends, innovative strategies and trial designs likely to impact the global immuno-oncology market in the future.

- Organize your sales and marketing efforts by understanding the immunotherapy combination approaches across indications that present maximum opportunities for consolidations, investments, and strategic partnerships.



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1 Table of Contents

1. Introduction

1.1 Related Reports 3

1.2 Upcoming Related Reports 4

2. Executive Summary 8

2.1 KOL Insight 6

2.2 GlobalData Insight 10

3. Research Panel Composition 14

3.1 5EU 15

3.2 US 16

4. Results and Implications 17

4.1 Future Use of Immunotherapy 18

4.1.1 Patterns in Unmet Needs 19

4.1.2 Clinical Potential of I-O in Oncology 22

4.1.3 Optimal Place for I-O in Treatment Algorithms 24

4.2 Challenges in I-O Trial Design 26

4.2.1 Predictive Biomarkers 30

4.2.2 Clinically Relevant Endpoints 35

4.2.3 Study Recruitment 38

4.2.4 Single-Arm Studies for Regulatory Approval 40

4.3 I-O Approaches and Combination Strategies 44

4.3.1 Potential of I-O Combinations 45

4.3.2 Potential of Novel Agents by Mechanism of Action 51

5. Appendix 54

5.1 Methodology 55

5.2 About the Authors 56

5.3 About GlobalData 58

5.4 Contact Us 59

5.5 Disclaimer 60

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