Global Liver Diseases Therapeutics Market

The Global Liver Diseases Therapeutics Market, valued at USD 25.9 billion, is growing due to increasing liver disease cases, technological advancements, and key players in North America and Europe.

Region:Global

Author(s):Dev

Product Code:KRAA3017

Pages:92

Published On:August 2025

About the Report

Base Year 2024

Global Liver Diseases Therapeutics Market Overview

  • The Global Liver Diseases Therapeutics Market is valued at USD 25.9 billion, based on a five-year historical analysis. This growth is primarily driven by the increasing prevalence of liver diseases such as hepatitis, non-alcoholic fatty liver disease (NAFLD), and liver cancer, as well as advancements in drug development, rising healthcare expenditure, and the growing burden of obesity and diabetes. The market is further supported by heightened awareness of liver health, early diagnosis initiatives, and the expansion of advanced diagnostic and therapeutic options .
  • Key players in this market are predominantly located in North America and Europe, with the United States and Germany being the most significant contributors. The dominance of these regions is attributed to their advanced healthcare infrastructure, substantial investment in research and development, and a strong presence of leading pharmaceutical and biotechnology companies .
  • The U.S. government has implemented several public health initiatives to address liver diseases, including the "Viral Hepatitis National Strategic Plan for the United States: A Roadmap to Elimination 2021–2025" issued by the U.S. Department of Health and Human Services. This binding policy outlines comprehensive strategies for prevention, early detection, and treatment of viral hepatitis, and mandates federal funding for research, surveillance, and public health campaigns to improve patient outcomes and reduce healthcare costs .
Global Liver Diseases Therapeutics Market Size

Global Liver Diseases Therapeutics Market Segmentation

By Treatment Type:The treatment type segmentation includes antiviral drugs, antifibrotic agents, immunosuppressants, chemotherapy & targeted therapy, vaccines, immunoglobulins, corticosteroids, and others. Among these,antiviral drugsare currently leading the market due to their effectiveness in treating viral hepatitis, particularly hepatitis B and C, which remain major causes of liver disease globally. The rising incidence of these infections, coupled with the introduction of novel direct-acting antivirals and combination therapies, has driven demand for these treatments and positioned them as a focal point for pharmaceutical innovation .

Global Liver Diseases Therapeutics Market segmentation by Treatment Type.

By End-User:The end-user segmentation encompasses hospitals, specialty clinics, homecare settings, and research institutions.Hospitalsare the leading end-user segment, primarily due to their capacity to provide comprehensive care, advanced treatment modalities, and access to specialized liver disease units. The increasing number of hospital admissions for liver-related conditions and the availability of multidisciplinary expertise further contribute to the dominance of this segment .

Global Liver Diseases Therapeutics Market segmentation by End-User.

Global Liver Diseases Therapeutics Market Competitive Landscape

The Global Liver Diseases Therapeutics Market is characterized by a dynamic mix of regional and international players. Leading participants such as Gilead Sciences, Inc., AbbVie Inc., Merck & Co., Inc., Bristol-Myers Squibb Company, Novartis AG, F. Hoffmann-La Roche AG, Johnson & Johnson (Janssen Pharmaceuticals), Amgen Inc., Intercept Pharmaceuticals, Inc., Vertex Pharmaceuticals Incorporated, Dicerna Pharmaceuticals, Inc., Zymeworks Inc., Eiger BioPharmaceuticals, Inc., Hepion Pharmaceuticals, Inc., Galmed Pharmaceuticals Ltd., Madrigal Pharmaceuticals, Inc., Viking Therapeutics, Inc., Alnylam Pharmaceuticals, Inc., CymaBay Therapeutics, Inc., Takeda Pharmaceutical Company Limited contribute to innovation, geographic expansion, and service delivery in this space.

Gilead Sciences, Inc.

1987

Foster City, California, USA

AbbVie Inc.

2013

North Chicago, Illinois, USA

Merck & Co., Inc.

1891

Kenilworth, New Jersey, USA

Bristol-Myers Squibb Company

1887

New York City, New York, USA

Novartis AG

1996

Basel, Switzerland

Company

Establishment Year

Headquarters

R&D Expenditure as % of Revenue

Number of Approved Liver Disease Drugs

Pipeline Candidates (Phase II/III)

Geographic Market Presence

Market Share in Key Indications (e.g., Hepatitis, NAFLD, HCC)

Strategic Collaborations & Licensing Deals

Global Liver Diseases Therapeutics Market Industry Analysis

Growth Drivers

  • Increasing Prevalence of Liver Diseases:The global incidence of liver diseases is rising, with an estimated 2 million deaths attributed to liver-related conditions annually, according to the World Health Organization. In future, the number of individuals diagnosed with chronic liver disease is projected to exceed 1.5 million in the None region alone. This growing patient population drives demand for effective therapeutics, prompting pharmaceutical companies to invest in research and development to address this urgent health crisis.
  • Advancements in Therapeutic Technologies:The liver diseases therapeutics sector is witnessing significant technological advancements, particularly in drug development and delivery systems. In future, over 50 new liver disease therapies are expected to enter clinical trials, reflecting a robust pipeline. Innovations such as gene therapy and targeted drug delivery are enhancing treatment efficacy, which is crucial for managing complex liver conditions, thereby attracting investment and fostering market growth in None.
  • Rising Healthcare Expenditure:Healthcare spending in None is projected to reach $500 billion in future, driven by increased government and private sector investments. This surge in expenditure is facilitating better access to liver disease treatments and improving healthcare infrastructure. Enhanced funding for liver disease research and treatment programs is expected to support the development of new therapies, ultimately benefiting patients and healthcare providers in the region.

Market Challenges

  • High Cost of Treatment:The financial burden of liver disease treatments remains a significant challenge, with average annual treatment costs exceeding $30,000 per patient in None. This high cost limits access to necessary therapies for many patients, particularly in lower-income demographics. As a result, healthcare providers face difficulties in managing treatment plans effectively, which can lead to poorer health outcomes and increased long-term healthcare costs.
  • Limited Availability of Effective Therapies:Despite advancements, there are still limited effective therapies for certain liver diseases, particularly for conditions like non-alcoholic steatohepatitis (NASH). In future, only 20% of patients with NASH are expected to have access to approved treatments. This scarcity of effective options poses a significant challenge for healthcare providers, as they struggle to offer comprehensive care to patients suffering from these complex conditions.

Global Liver Diseases Therapeutics Market Future Outlook

The future of liver disease therapeutics in None appears promising, driven by ongoing research and technological advancements. The integration of personalized medicine is expected to enhance treatment efficacy, while digital health solutions will facilitate better patient management. Additionally, the rise of telemedicine is likely to improve access to care, particularly in underserved areas. These trends indicate a shift towards more effective and accessible liver disease management strategies, ultimately improving patient outcomes in the region.

Market Opportunities

  • Emerging Markets for Liver Disease Therapeutics:The growing economies in None present significant opportunities for liver disease therapeutics. With increasing healthcare investments and rising awareness, the demand for innovative treatments is expected to surge. This trend is likely to attract pharmaceutical companies looking to expand their market presence and cater to the evolving needs of patients in these regions.
  • Collaborations and Partnerships for Research:Strategic collaborations between pharmaceutical companies and research institutions are becoming increasingly common. In future, over 30 partnerships focused on liver disease research are anticipated, fostering innovation and accelerating the development of new therapies. These collaborations can enhance resource sharing and expertise, ultimately leading to breakthroughs in liver disease treatment options.

Scope of the Report

SegmentSub-Segments
By Treatment Type

Antiviral Drugs

Antifibrotic Agents

Immunosuppressants

Chemotherapy & Targeted Therapy

Vaccines

Immunoglobulins

Corticosteroids

Others

By End-User

Hospitals

Specialty Clinics

Homecare Settings

Research Institutions

By Route of Administration

Oral

Injectable

Transdermal

By Disease Type

Hepatitis (A, B, C, D, E)

Non-Alcoholic Fatty Liver Disease (NAFLD) / Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Alcoholic Liver Disease

Liver Cancer (Hepatocellular Carcinoma, Cholangiocarcinoma)

Autoimmune Liver Diseases (e.g., Autoimmune Hepatitis, Primary Biliary Cholangitis, Primary Sclerosing Cholangitis)

Genetic/Metabolic Liver Diseases (e.g., Wilson’s Disease, Hemochromatosis)

By Distribution Channel

Hospital Pharmacies

Retail Pharmacies

Online Pharmacies

By Region

North America

Europe

Asia-Pacific

Latin America

Middle East & Africa

By Patient Demographics

Adults

Pediatric

Geriatric

Key Target Audience

Investors and Venture Capitalist Firms

Government and Regulatory Bodies (e.g., U.S. Food and Drug Administration, European Medicines Agency)

Pharmaceutical Manufacturers

Biotechnology Companies

Healthcare Providers and Hospitals

Health Insurance Companies

Clinical Research Organizations

Pharmaceutical Supply Chain Stakeholders

Players Mentioned in the Report:

Gilead Sciences, Inc.

AbbVie Inc.

Merck & Co., Inc.

Bristol-Myers Squibb Company

Novartis AG

F. Hoffmann-La Roche AG

Johnson & Johnson (Janssen Pharmaceuticals)

Amgen Inc.

Intercept Pharmaceuticals, Inc.

Vertex Pharmaceuticals Incorporated

Dicerna Pharmaceuticals, Inc.

Zymeworks Inc.

Eiger BioPharmaceuticals, Inc.

Hepion Pharmaceuticals, Inc.

Galmed Pharmaceuticals Ltd.

Madrigal Pharmaceuticals, Inc.

Viking Therapeutics, Inc.

Alnylam Pharmaceuticals, Inc.

CymaBay Therapeutics, Inc.

Takeda Pharmaceutical Company Limited

Table of Contents

Market Assessment Phase

1. Executive Summary and Approach


2. Global Liver Diseases Therapeutics Market Overview

2.1 Key Insights and Strategic Recommendations

2.2 Global Liver Diseases Therapeutics Market Overview

2.3 Definition and Scope

2.4 Evolution of Market Ecosystem

2.5 Timeline of Key Regulatory Milestones

2.6 Value Chain & Stakeholder Mapping

2.7 Business Cycle Analysis

2.8 Policy & Incentive Landscape


3. Global Liver Diseases Therapeutics Market Analysis

3.1 Growth Drivers

3.1.1 Increasing prevalence of liver diseases
3.1.2 Advancements in therapeutic technologies
3.1.3 Rising healthcare expenditure
3.1.4 Growing awareness and screening programs

3.2 Market Challenges

3.2.1 High cost of treatment
3.2.2 Limited availability of effective therapies
3.2.3 Stringent regulatory requirements
3.2.4 Competition from alternative treatments

3.3 Market Opportunities

3.3.1 Emerging markets for liver disease therapeutics
3.3.2 Development of personalized medicine
3.3.3 Collaborations and partnerships for research
3.3.4 Innovations in drug delivery systems

3.4 Market Trends

3.4.1 Shift towards biologics and biosimilars
3.4.2 Increasing focus on preventive care
3.4.3 Integration of digital health solutions
3.4.4 Rise in telemedicine for liver disease management

3.5 Government Regulation

3.5.1 Regulatory frameworks for drug approval
3.5.2 Guidelines for clinical trials
3.5.3 Policies on pricing and reimbursement
3.5.4 Initiatives for public health awareness

4. SWOT Analysis


5. Stakeholder Analysis


6. Porter's Five Forces Analysis


7. Global Liver Diseases Therapeutics Market Market Size, 2019-2024

7.1 By Value

7.2 By Volume

7.3 By Average Selling Price


8. Global Liver Diseases Therapeutics Market Segmentation

8.1 By Treatment Type

8.1.1 Antiviral Drugs
8.1.2 Antifibrotic Agents
8.1.3 Immunosuppressants
8.1.4 Chemotherapy & Targeted Therapy
8.1.5 Vaccines
8.1.6 Immunoglobulins
8.1.7 Corticosteroids
8.1.8 Others

8.2 By End-User

8.2.1 Hospitals
8.2.2 Specialty Clinics
8.2.3 Homecare Settings
8.2.4 Research Institutions

8.3 By Route of Administration

8.3.1 Oral
8.3.2 Injectable
8.3.3 Transdermal

8.4 By Disease Type

8.4.1 Hepatitis (A, B, C, D, E)
8.4.2 Non-Alcoholic Fatty Liver Disease (NAFLD) / Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
8.4.3 Alcoholic Liver Disease
8.4.4 Liver Cancer (Hepatocellular Carcinoma, Cholangiocarcinoma)
8.4.5 Autoimmune Liver Diseases (e.g., Autoimmune Hepatitis, Primary Biliary Cholangitis, Primary Sclerosing Cholangitis)
8.4.6 Genetic/Metabolic Liver Diseases (e.g., Wilson’s Disease, Hemochromatosis)

8.5 By Distribution Channel

8.5.1 Hospital Pharmacies
8.5.2 Retail Pharmacies
8.5.3 Online Pharmacies

8.6 By Region

8.6.1 North America
8.6.2 Europe
8.6.3 Asia-Pacific
8.6.4 Latin America
8.6.5 Middle East & Africa

8.7 By Patient Demographics

8.7.1 Adults
8.7.2 Pediatric
8.7.3 Geriatric

9. Global Liver Diseases Therapeutics Market Competitive Analysis

9.1 Market Share of Key Players

9.2 KPIs for Cross Comparison of Key Players

9.2.1 Revenue from Liver Disease Therapeutics
9.2.2 R&D Expenditure as % of Revenue
9.2.3 Number of Approved Liver Disease Drugs
9.2.4 Pipeline Candidates (Phase II/III)
9.2.5 Geographic Market Presence
9.2.6 Market Share in Key Indications (e.g., Hepatitis, NAFLD, HCC)
9.2.7 Strategic Collaborations & Licensing Deals
9.2.8 Time-to-Market for New Therapies
9.2.9 Regulatory Approval Success Rate
9.2.10 Patient Access/Reach (e.g., number of treated patients annually)

9.3 SWOT Analysis of Top Players

9.4 Pricing Analysis

9.5 Detailed Profile of Major Companies

9.5.1 Gilead Sciences, Inc.
9.5.2 AbbVie Inc.
9.5.3 Merck & Co., Inc.
9.5.4 Bristol-Myers Squibb Company
9.5.5 Novartis AG
9.5.6 F. Hoffmann-La Roche AG
9.5.7 Johnson & Johnson (Janssen Pharmaceuticals)
9.5.8 Amgen Inc.
9.5.9 Intercept Pharmaceuticals, Inc.
9.5.10 Vertex Pharmaceuticals Incorporated
9.5.11 Dicerna Pharmaceuticals, Inc.
9.5.12 Zymeworks Inc.
9.5.13 Eiger BioPharmaceuticals, Inc.
9.5.14 Hepion Pharmaceuticals, Inc.
9.5.15 Galmed Pharmaceuticals Ltd.
9.5.16 Madrigal Pharmaceuticals, Inc.
9.5.17 Viking Therapeutics, Inc.
9.5.18 Alnylam Pharmaceuticals, Inc.
9.5.19 CymaBay Therapeutics, Inc.
9.5.20 Takeda Pharmaceutical Company Limited

10. Global Liver Diseases Therapeutics Market End-User Analysis

10.1 Procurement Behavior of Key Ministries

10.1.1 Government health departments
10.1.2 Public health organizations
10.1.3 Non-profit health agencies

10.2 Corporate Spend on Infrastructure & Energy

10.2.1 Investment in healthcare facilities
10.2.2 Funding for liver disease research
10.2.3 Expenditure on medical equipment

10.3 Pain Point Analysis by End-User Category

10.3.1 Access to affordable treatments
10.3.2 Availability of specialized care
10.3.3 Need for patient education

10.4 User Readiness for Adoption

10.4.1 Awareness of liver disease risks
10.4.2 Acceptance of new therapies
10.4.3 Readiness for telehealth solutions

10.5 Post-Deployment ROI and Use Case Expansion

10.5.1 Evaluation of treatment outcomes
10.5.2 Expansion into new patient demographics
10.5.3 Long-term cost savings analysis

11. Global Liver Diseases Therapeutics Market Future Size, 2025-2030

11.1 By Value

11.2 By Volume

11.3 By Average Selling Price


Go-To-Market Strategy Phase

1. Whitespace Analysis + Business Model Canvas

1.1 Market gaps identification

1.2 Value proposition development

1.3 Revenue model exploration

1.4 Customer segmentation analysis

1.5 Competitive landscape overview


2. Marketing and Positioning Recommendations

2.1 Branding strategies

2.2 Product USPs

2.3 Target audience identification

2.4 Communication strategies


3. Distribution Plan

3.1 Urban retail strategies

3.2 Rural NGO tie-ups

3.3 Online distribution channels

3.4 Partnerships with healthcare providers


4. Channel & Pricing Gaps

4.1 Underserved routes

4.2 Pricing bands analysis

4.3 Competitor pricing strategies


5. Unmet Demand & Latent Needs

5.1 Category gaps identification

5.2 Consumer segments analysis

5.3 Emerging trends in consumer behavior


6. Customer Relationship

6.1 Loyalty programs

6.2 After-sales service

6.3 Customer feedback mechanisms


7. Value Proposition

7.1 Sustainability initiatives

7.2 Integrated supply chains

7.3 Unique selling points


8. Key Activities

8.1 Regulatory compliance

8.2 Branding efforts

8.3 Distribution setup


9. Entry Strategy Evaluation

9.1 Domestic Market Entry Strategy

9.1.1 Product mix considerations
9.1.2 Pricing band strategies
9.1.3 Packaging innovations

9.2 Export Entry Strategy

9.2.1 Target countries analysis
9.2.2 Compliance roadmap development

10. Entry Mode Assessment

10.1 Joint Ventures

10.2 Greenfield investments

10.3 Mergers & Acquisitions

10.4 Distributor Model evaluation


11. Capital and Timeline Estimation

11.1 Capital requirements analysis

11.2 Timelines for market entry


12. Control vs Risk Trade-Off

12.1 Ownership considerations

12.2 Partnerships evaluation


13. Profitability Outlook

13.1 Breakeven analysis

13.2 Long-term sustainability strategies


14. Potential Partner List

14.1 Distributors

14.2 Joint Ventures

14.3 Acquisition targets


15. Execution Roadmap

15.1 Phased Plan for Market Entry

15.1.1 Market Setup
15.1.2 Market Entry
15.1.3 Growth Acceleration
15.1.4 Scale & Stabilize

15.2 Key Activities and Milestones

15.2.1 Milestone tracking
15.2.2 Activity scheduling

Research Methodology

ApproachModellingSample

Phase 1: Approach1

Desk Research

  • Analysis of published reports from global health organizations and liver disease associations
  • Review of market data from pharmaceutical industry databases and journals
  • Examination of clinical trial registries and outcomes related to liver disease therapeutics

Primary Research

  • Interviews with hepatologists and gastroenterologists specializing in liver diseases
  • Surveys with pharmaceutical executives involved in liver disease drug development
  • Focus groups with patients and caregivers to understand treatment experiences and preferences

Validation & Triangulation

  • Cross-validation of findings through multiple expert interviews and literature reviews
  • Triangulation of data from clinical studies, market reports, and expert opinions
  • Sanity checks through feedback from advisory panels comprising industry experts

Phase 2: Market Size Estimation1

Top-down Assessment

  • Estimation of total addressable market based on global liver disease prevalence rates
  • Segmentation of market by therapeutic class, including antivirals, immunotherapies, and supportive care
  • Incorporation of market trends influenced by regulatory approvals and emerging therapies

Bottom-up Modeling

  • Collection of sales data from leading pharmaceutical companies focused on liver disease treatments
  • Estimation of market share based on product launch timelines and sales forecasts
  • Volume and pricing analysis based on historical sales data and projected growth rates

Forecasting & Scenario Analysis

  • Multi-factor regression analysis incorporating demographic shifts and healthcare spending
  • Scenario modeling based on potential drug approvals and market entry of new therapies
  • Baseline, optimistic, and pessimistic forecasts through 2030, considering market dynamics

Phase 3: CATI Sample Composition1

Scope Item/SegmentSample SizeTarget Respondent Profiles
Hepatitis C Treatment Insights60Hepatologists, Infectious Disease Specialists
Non-Alcoholic Fatty Liver Disease (NAFLD) Management50Primary Care Physicians, Nutritionists
Cirrhosis Patient Care Strategies40Nurses, Care Coordinators
Clinical Trial Participation Feedback45Clinical Research Coordinators, Patients
Market Access and Reimbursement Perspectives55Pharmaceutical Market Access Managers, Payers

Frequently Asked Questions

What is the current value of the Global Liver Diseases Therapeutics Market?

The Global Liver Diseases Therapeutics Market is valued at approximately USD 25.9 billion, driven by the rising prevalence of liver diseases such as hepatitis, non-alcoholic fatty liver disease (NAFLD), and liver cancer, along with advancements in drug development and increased healthcare expenditure.

What are the main drivers of growth in the liver diseases therapeutics market?

Which regions dominate the Global Liver Diseases Therapeutics Market?

What types of treatments are available in the liver diseases therapeutics market?

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