KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) - Pipeline Review, H2 2016

KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) - Pipeline Review, H2 2016


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Executive Summary

KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) - Pipeline Review, H2 2016

Summary

Global Markets Direct's, 'KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) - Pipeline Review, H2 2016', provides in depth analysis on KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) targeted pipeline therapeutics.

The report provides comprehensive information on the KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) , targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved in KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) targeted therapeutics development and features dormant and discontinued projects.

Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Drug profiles featured in the report undergoes periodic review following a stringent set of processes to ensure that all the profiles are updated with the latest set of information. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis.

The report helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage.

Note:

*Certain sections in the report may be removed or altered based on the availability and relevance of data.

*Updated report will be delivered in 48 hours of order confirmation.

Scope

- The report provides a snapshot of the global therapeutic landscape for KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R)

- The report reviews KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources

- The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages

- The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities

- The report reviews key players involved in KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) targeted therapeutics and enlists all their major and minor projects

- The report assesses KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type

- The report summarizes all the dormant and discontinued pipeline projects

- The report reviews latest news and deals related to KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) targeted therapeutics

Reasons to buy

- Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies

- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage

- Identify and understand the targeted therapy areas and indications for KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R)

- Identify the use of drugs for target identification and drug repurposing

- Identify potential new clients or partners in the target demographic

- Develop strategic initiatives by understanding the focus areas of leading companies

- Plan mergers and acquisitions effectively by identifying key players and it's most promising pipeline therapeutics

- Devise corrective measures for pipeline projects by understanding KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) development landscape

- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope



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Table of Contents

Table of Contents 2

List of Tables 4

List of Figures 4

Introduction 5

Global Markets Direct Report Coverage 5

KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) Overview 6

Therapeutics Development 7

KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) - Products under Development by Stage of Development 7

KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) - Products under Development by Therapy Area 8

KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) - Products under Development by Indication 9

KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) - Pipeline Products Glance 10

Late Stage Products 10

Early Stage Products 11

KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) - Products under Development by Companies 12

KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) - Products under Development by Universities/Institutes 14

KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) - Therapeutics Assessment 16

Assessment by Monotherapy/Combination Products 16

Assessment by Mechanism of Action 17

Assessment by Route of Administration 19

Assessment by Molecule Type 21

KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) - Companies Involved in Therapeutics Development 23

Crinetics Pharmaceuticals, Inc. 23

Millennium Pharmaceuticals Inc 24

KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) - Drug Profiles 25

Kisspeptin-10 - Drug Profile 25

Product Description 25

Mechanism Of Action 25

R&D Progress 25

kisspeptin-54 - Drug Profile 26

Product Description 26

Mechanism Of Action 26

R&D Progress 26

Small Molecules to Inhibit KISS-1R for Polycystic Ovarian Syndrome - Drug Profile 27

Product Description 27

Mechanism Of Action 27

R&D Progress 27

Synthetic Peptide to Antagonize GPR54 for Womens Health, Male Health and Oncology - Drug Profile 28

Product Description 28

Mechanism Of Action 28

R&D Progress 28

TAK-448 - Drug Profile 29

Product Description 29

Mechanism Of Action 29

R&D Progress 29

KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) - Discontinued Products 31

KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) - Featured News & Press Releases 32

Jan 28, 2015: Crinetics Pharmaceuticals Awarded $1.5MM NIH Phase-II SBIR Grant to Develop Kisspeptin Receptor Antagonists for PCOS and Other Women's Health Diseases 32

Jun 18, 2013: Kisspeptin hormone could make IVF safer for mothers 32

Appendix 34

Methodology 34

Coverage 34

Secondary Research 34

Primary Research 34

Expert Panel Validation 34

Contact Us 34

Disclaimer 35

List of Figures

Number of Products under Development for, H2 2016 7

Number of Products under Development by Therapy Area, H2 2016 8

Number of Products under Development by Indication, H2 2016 9

Comparative Analysis by Early Stage Products, H2 2016 11

Assessment by Monotherapy/Combination Products, H2 2016 16

Number of Products by Mechanism of Actions, H2 2016 17

Number of Products by Stage and Mechanism of Action, H2 2016 17

Number of Products by Routes of Administration, H2 2016 19

Number of Products by Stage and Routes of Administration, H2 2016 19

Number of Products by Molecule Types, H2 2016 21

Number of Products by Stage and Molecule Type, H2 2016 21

List of Tables

Number of Products under Development for, H2 2016 7

Number of Products under Development by Therapy Area, H2 2016 8

Number of Products under Development by Indication, H2 2016 9

Comparative Analysis by Late Stage Development, H2 2016 10

Comparative Analysis by Early Stage Products, H2 2016 11

Number of Products under Development by Companies, H2 2016 12

Products under Development by Companies, H2 2016 13

Number of Products under Investigation by Universities/Institutes, H2 2016 14

Products under Investigation by Universities/Institutes, H2 2016 15

Assessment by Monotherapy/Combination Products, H2 2016 16

Number of Products by Stage and Mechanism of Action, H2 2016 18

Number of Products by Stage and Route of Administration, H2 2016 20

Number of Products by Stage and Molecule Type, H2 2016 22

Pipeline by Crinetics Pharmaceuticals, Inc., H2 2016 23

Pipeline by Millennium Pharmaceuticals Inc, H2 2016 24

Discontinued Products, H2 2016 31

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Crinetics Pharmaceuticals, Inc.

Millennium Pharmaceuticals Inc

KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) Therapeutic Products under Development, Key Players in KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) Therapeutics, KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) Pipeline Overview, KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) Pipeline, KiSS 1 Receptor (G Protein Coupled Receptor 54 or G Protein Coupled Receptor OT7T175 or Hypogonadotropin 1 or Kisspeptins Receptor or Metastin Receptor or GPR54 or KISS1R) Pipeline Assessment

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