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Neurofibromatoses Type II-Pipeline Review, H1 2015

Neurofibromatoses Type II-Pipeline Review, H1 2015


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Executive Summary

Neurofibromatoses Type II-Pipeline Review, H1 2015

Summary

Global Markets Direct's, 'Neurofibromatoses Type II-Pipeline Review, H1 2015', provides an overview of the Neurofibromatoses Type II's therapeutic pipeline.

This report provides comprehensive information on the therapeutic development for Neurofibromatoses Type II, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Neurofibromatoses Type II and special features on late-stage and discontinued projects.

Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis.

The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.

Scope

The report provides a snapshot of the global therapeutic landscape of Neurofibromatoses Type II

The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities

The report reviews key players involved in the therapeutics development for Neurofibromatoses Type II and enlists all their major and minor projects

The report summarizes all the dormant and discontinued pipeline projects

A review of the Neurofibromatoses Type II products under development by companies and universities/research institutes based on information derived from company and industry-specific sources

Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages

A detailed assessment of monotherapy and combination therapy pipeline projects

Coverage of the Neurofibromatoses Type II pipeline on the basis of target, MoA, route of administration and molecule type

Latest news and deals relating related to pipeline products

Reasons To Buy

Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies

Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage

Develop strategic initiatives by understanding the focus areas of leading companies

Identify and understand important and diverse types of therapeutics under development for Neurofibromatoses Type II

Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline

Devise corrective measures for pipeline projects by understanding Neurofibromatoses Type II pipeline depth and focus of Indication therapeutics

Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline

Table of Contents

Table of Contents 2

List of Tables 4

List of Figures 4

Introduction 5

Global Markets Direct Report Coverage 5

Neurofibromatoses Type II Overview 6

Therapeutics Development 7

Pipeline Products for Neurofibromatoses Type II-Overview 7

Pipeline Products for Neurofibromatoses Type II-Comparative Analysis 8

Neurofibromatoses Type II-Therapeutics under Development by Companies 9

Neurofibromatoses Type II-Therapeutics under Investigation by Universities/Institutes 10

Neurofibromatoses Type II-Pipeline Products Glance 11

Early Stage Products 11

Neurofibromatoses Type II-Products under Development by Companies 12

Neurofibromatoses Type II-Products under Investigation by Universities/Institutes 13

Neurofibromatoses Type II-Companies Involved in Therapeutics Development 14

Arno Therapeutics, Inc. 14

CalAsia Pharmaceuticals, Inc. 15

Nexgenix Pharmaceuticals, LLC 16

Lixte Biotechnology Holdings, Inc. 17

Neurofibromatoses Type II-Therapeutics Assessment 18

Assessment by Monotherapy Products 18

Assessment by Target 19

Assessment by Mechanism of Action 21

Assessment by Route of Administration 23

Assessment by Molecule Type 25

Drug Profiles 26

AR-42-Drug Profile 26

Product Description 26

Mechanism of Action 26

R&D Progress 26

FRAX-597-Drug Profile 28

Product Description 28

Mechanism of Action 28

R&D Progress 28

LB-201-Drug Profile 29

Product Description 29

Mechanism of Action 29

R&D Progress 29

LB-205-Drug Profile 30

Product Description 30

Mechanism of Action 30

R&D Progress 30

NXD-30001-Drug Profile 31

Product Description 31

Mechanism of Action 31

R&D Progress 31

Small Molecules to Inhibit Hsp90 for Neurofibromatosis Type 2-Drug Profile 33

Product Description 33

Mechanism of Action 33

R&D Progress 33

Neurofibromatoses Type II-Recent Pipeline Updates 34

Neurofibromatoses Type II-Dormant Projects 36

Neurofibromatoses Type II-Product Development Milestones 37

Featured News & Press Releases 37

May 11, 2012: Arno Therapeutics Receives European Orphan Drug Designation For AR-42 37

Appendix 38

Methodology 38

Coverage 38

Secondary Research 38

Primary Research 38

Expert Panel Validation 38

Contact Us 38

Disclaimer 39

List of Tables

Number of Products under Development for Neurofibromatoses Type II, H1 2015 7

Number of Products under Development for Neurofibromatoses Type II-Comparative Analysis, H1 2015 8

Number of Products under Development by Companies, H1 2015 9

Number of Products under Investigation by Universities/Institutes, H1 2015 10

Comparative Analysis by Early Stage Development, H1 2015 11

Products under Development by Companies, H1 2015 12

Products under Investigation by Universities/Institutes, H1 2015 13

Neurofibromatoses Type II-Pipeline by Arno Therapeutics, Inc., H1 2015 14

Neurofibromatoses Type II-Pipeline by CalAsia Pharmaceuticals, Inc., H1 2015 15

Neurofibromatoses Type II-Pipeline by Nexgenix Pharmaceuticals, LLC, H1 2015 16

Neurofibromatoses Type II-Pipeline by Lixte Biotechnology Holdings, Inc., H1 2015 17

Assessment by Monotherapy Products, H1 2015 18

Number of Products by Stage and Target, H1 2015 20

Number of Products by Stage and Mechanism of Action, H1 2015 22

Number of Products by Stage and Route of Administration, H1 2015 24

Number of Products by Stage and Molecule Type, H1 2015 25

Neurofibromatoses Type II Therapeutics-Recent Pipeline Updates, H1 2015 34

Neurofibromatoses Type II-Dormant Projects, H1 2015 36

List of Figures

Number of Products under Development for Neurofibromatoses Type II, H1 2015 7

Number of Products under Development for Neurofibromatoses Type II-Comparative Analysis, H1 2015 8

Number of Products under Development by Companies, H1 2015 9

Comparative Analysis by Early Stage Products, H1 2015 11

Assessment by Monotherapy Products, H1 2015 18

Number of Products by Top 10 Targets, H1 2015 19

Number of Products by Stage and Top 10 Targets, H1 2015 20

Number of Products by Top 10 Mechanism of Actions, H1 2015 21

Number of Products by Stage and Top 10 Mechanism of Actions, H1 2015 22

Number of Products by Top 10 Routes of Administration, H1 2015 23

Number of Products by Stage and Top 10 Routes of Administration, H1 2015 24

Number of Products by Stage and Top 10 Molecule Types, H1 2015 25

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Arno Therapeutics, Inc.

CalAsia Pharmaceuticals, Inc.

Nexgenix Pharmaceuticals, LLC

Lixte Biotechnology Holdings, Inc.

Neurofibromatoses Type II Therapeutic Products under Development, Key Players in Neurofibromatoses Type II Therapeutics, Neurofibromatoses Type II Pipeline Overview, Neurofibromatoses Type II Pipeline, Neurofibromatoses Type II Pipeline Assessment


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