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Synovial Sarcoma-Pipeline Review, H1 2015

Synovial Sarcoma-Pipeline Review, H1 2015


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Executive Summary

Synovial Sarcoma-Pipeline Review, H1 2015

Summary

Global Markets Direct's, 'Synovial Sarcoma-Pipeline Review, H1 2015', provides an overview of the Synovial Sarcoma's therapeutic pipeline.

This report provides comprehensive information on the therapeutic development for Synovial Sarcoma, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Synovial Sarcoma and special features on late-stage and discontinued projects.

Global Markets Direct's report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct's proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct's team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis.

The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.

Scope

The report provides a snapshot of the global therapeutic landscape of Synovial Sarcoma

The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities

The report reviews key players involved in the therapeutics development for Synovial Sarcoma and enlists all their major and minor projects

The report summarizes all the dormant and discontinued pipeline projects

A review of the Synovial Sarcoma products under development by companies and universities/research institutes based on information derived from company and industry-specific sources

Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages

A detailed assessment of monotherapy and combination therapy pipeline projects

Coverage of the Synovial Sarcoma pipeline on the basis of target, MoA, route of administration and molecule type

Latest news and deals relating related to pipeline products

Reasons To Buy

Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies

Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage

Develop strategic initiatives by understanding the focus areas of leading companies

Identify and understand important and diverse types of therapeutics under development for Synovial Sarcoma

Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline

Devise corrective measures for pipeline projects by understanding Synovial Sarcoma pipeline depth and focus of Indication therapeutics

Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline

Table of Contents

Table of Contents 2

List of Tables 4

List of Figures 4

Introduction 5

Global Markets Direct Report Coverage 5

Synovial Sarcoma Overview 6

Therapeutics Development 7

Pipeline Products for Synovial Sarcoma-Overview 7

Pipeline Products for Synovial Sarcoma-Comparative Analysis 8

Synovial Sarcoma-Therapeutics under Development by Companies 9

Synovial Sarcoma-Therapeutics under Investigation by Universities/Institutes 10

Synovial Sarcoma-Pipeline Products Glance 11

Clinical Stage Products 11

Early Stage Products 12

Unknown Stage Products 13

Synovial Sarcoma-Products under Development by Companies 14

Synovial Sarcoma-Products under Investigation by Universities/Institutes 15

Synovial Sarcoma-Companies Involved in Therapeutics Development 16

Adaptimmune Limited 16

Eisai Co., Ltd. 17

Karyopharm Therapeutics, Inc. 18

Merck & Co., Inc. 19

Novartis AG 20

OncoTherapy Science, Inc. 21

Synovial Sarcoma-Therapeutics Assessment 22

Assessment by Monotherapy Products 22

Assessment by Target 23

Assessment by Mechanism of Action 25

Assessment by Route of Administration 27

Assessment by Molecule Type 29

Drug Profiles 31

Cell Therapy to Target NY-ESO-1 and LAGE-1 for Oncology-Drug Profile 31

Product Description 31

Mechanism of Action 31

R&D Progress 31

Dendritic Cell Therapy to Target MAGE-A1, MAGE-A3 and NY-ESO-1 for Oncology-Drug Profile 33

Product Description 33

Mechanism of Action 33

R&D Progress 33

E-7438-Drug Profile 34

Product Description 34

Mechanism of Action 34

R&D Progress 34

everolimus-Drug Profile 36

Product Description 36

Mechanism of Action 36

R&D Progress 36

OTSA-101-Drug Profile 41

Product Description 41

Mechanism of Action 41

R&D Progress 41

pembrolizumab-Drug Profile 42

Product Description 42

Mechanism of Action 42

R&D Progress 42

selinexor-Drug Profile 46

Product Description 46

Mechanism of Action 46

R&D Progress 46

SSTC-104-Drug Profile 50

Product Description 50

Mechanism of Action 50

R&D Progress 50

Synovial Sarcoma-Recent Pipeline Updates 51

Synovial Sarcoma-Discontinued Products 72

Synovial Sarcoma-Product Development Milestones 73

Featured News & Press Releases 73

Oct 17, 2014: Adaptimmune Announces Interim Results from Pilot Trial of its Engineered NY-ESO T Cells Targeting Synovial Sarcoma 73

Jul 30, 2012: OncoTherapy Science Receives Patent For OTSA101 In Japan And US 75

Oct 16, 2011: OncoTherapy Science's Subsidiary Receives French Approval For Clinical Trial Of OTSA101 75

Appendix 76

Methodology 76

Coverage 76

Secondary Research 76

Primary Research 76

Expert Panel Validation 76

Contact Us 76

Disclaimer 77

List of Tables

Number of Products under Development for Synovial Sarcoma, H1 2015 7

Number of Products under Development for Synovial Sarcoma-Comparative Analysis, H1 2015 8

Number of Products under Development by Companies, H1 2015 9

Number of Products under Investigation by Universities/Institutes, H1 2015 10

Comparative Analysis by Clinical Stage Development, H1 2015 11

Comparative Analysis by Early Stage Development, H1 2015 12

Comparative Analysis by Unknown Stage Development, H1 2015 13

Products under Development by Companies, H1 2015 14

Products under Investigation by Universities/Institutes, H1 2015 15

Synovial Sarcoma-Pipeline by Adaptimmune Limited, H1 2015 16

Synovial Sarcoma-Pipeline by Eisai Co., Ltd., H1 2015 17

Synovial Sarcoma-Pipeline by Karyopharm Therapeutics, Inc., H1 2015 18

Synovial Sarcoma-Pipeline by Merck & Co., Inc., H1 2015 19

Synovial Sarcoma-Pipeline by Novartis AG, H1 2015 20

Synovial Sarcoma-Pipeline by OncoTherapy Science, Inc., H1 2015 21

Assessment by Monotherapy Products, H1 2015 22

Number of Products by Stage and Target, H1 2015 24

Number of Products by Stage and Mechanism of Action, H1 2015 26

Number of Products by Stage and Route of Administration, H1 2015 28

Number of Products by Stage and Molecule Type, H1 2015 30

Synovial Sarcoma Therapeutics-Recent Pipeline Updates, H1 2015 51

Synovial Sarcoma-Discontinued Products, H1 2015 72

List of Figures

Number of Products under Development for Synovial Sarcoma, H1 2015 7

Number of Products under Development for Synovial Sarcoma-Comparative Analysis, H1 2015 8

Number of Products under Development by Companies, H1 2015 9

Comparative Analysis by Clinical Stage Development, H1 2015 11

Assessment by Monotherapy Products, H1 2015 22

Number of Products by Top 10 Targets, H1 2015 23

Number of Products by Stage and Top 10 Targets, H1 2015 23

Number of Products by Top 10 Mechanism of Actions, H1 2015 25

Number of Products by Stage and Top 10 Mechanism of Actions, H1 2015 25

Number of Products by Top 10 Routes of Administration, H1 2015 27

Number of Products by Stage and Top 10 Routes of Administration, H1 2015 27

Number of Products by Top 10 Molecule Types, H1 2015 29

Number of Products by Stage and Top 10 Molecule Types, H1 2015 29

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Adaptimmune Limited

Eisai Co., Ltd.

Karyopharm Therapeutics, Inc.

Merck & Co., Inc.

Novartis AG

OncoTherapy Science, Inc.

Synovial Sarcoma Therapeutic Products under Development, Key Players in Synovial Sarcoma Therapeutics, Synovial Sarcoma Pipeline Overview, Synovial Sarcoma Pipeline, Synovial Sarcoma Pipeline Assessment


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